全文获取类型
收费全文 | 2760篇 |
免费 | 187篇 |
国内免费 | 147篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 112篇 |
妇产科学 | 35篇 |
基础医学 | 360篇 |
口腔科学 | 55篇 |
临床医学 | 361篇 |
内科学 | 615篇 |
皮肤病学 | 56篇 |
神经病学 | 152篇 |
特种医学 | 459篇 |
外科学 | 272篇 |
综合类 | 29篇 |
一般理论 | 2篇 |
预防医学 | 126篇 |
眼科学 | 78篇 |
药学 | 182篇 |
1篇 | |
肿瘤学 | 178篇 |
出版年
2021年 | 23篇 |
2020年 | 22篇 |
2019年 | 29篇 |
2018年 | 38篇 |
2017年 | 26篇 |
2016年 | 43篇 |
2015年 | 47篇 |
2014年 | 50篇 |
2013年 | 95篇 |
2012年 | 93篇 |
2011年 | 87篇 |
2010年 | 84篇 |
2009年 | 83篇 |
2008年 | 99篇 |
2007年 | 199篇 |
2006年 | 102篇 |
2005年 | 111篇 |
2004年 | 91篇 |
2003年 | 87篇 |
2002年 | 79篇 |
2001年 | 102篇 |
2000年 | 70篇 |
1999年 | 83篇 |
1998年 | 114篇 |
1997年 | 101篇 |
1996年 | 92篇 |
1995年 | 80篇 |
1994年 | 59篇 |
1993年 | 66篇 |
1992年 | 46篇 |
1991年 | 51篇 |
1990年 | 45篇 |
1989年 | 70篇 |
1988年 | 49篇 |
1987年 | 48篇 |
1986年 | 47篇 |
1985年 | 45篇 |
1984年 | 35篇 |
1983年 | 20篇 |
1982年 | 32篇 |
1981年 | 21篇 |
1980年 | 19篇 |
1979年 | 32篇 |
1978年 | 15篇 |
1977年 | 23篇 |
1976年 | 42篇 |
1975年 | 32篇 |
1970年 | 13篇 |
1969年 | 18篇 |
1967年 | 13篇 |
排序方式: 共有3094条查询结果,搜索用时 703 毫秒
41.
A 15 year old boy with autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy syndrome suffered recurrent episodes of severe intractable diarrhoea, steatorrhoea, and hypocalcaemia. The only treatment modality, which controlled the malabsorption syndrome, was immunosuppression with intravenous high dose methylprednisolone and oral methotrexate maintenance therapy. 相似文献
42.
Wang WS; Hsieh RK; Chiou TJ; Liu JH; Fan FS; Yen CC; Tung SL; Chen PM 《Japanese journal of clinical oncology》1998,28(9):551-554
A 54-year-old man was treated with weekly 24-h infusion of high-dose
5-fluorouracil (2600 mg/m2) and leucovorin (100 mg/m2) for metastatic colon
cancer. At first, he tolerated the treatment well and no significant
toxicity was identified. After a total of eight courses of treatment, a
stable disease was observed, but mild shortness of breath was found on
occasion. The patient had no previous history of cardiac disease and the
heart performance assessed by left ventricular ejection fraction before
treatment was normal. Unfortunately, acute pulmonary edema with lethal
cardiogenic shock occurred during the ninth course of treatment, in spite
of intensive medical treatment. The chest X-ray showed extreme
cardiomegaly. Repeated assessment of his heart function by echocardiogram
and ventricular ejection fraction revealed a very poor cardiac performance.
Toxic cardiogenic shock during weekly 24-h infusion of high-dose
5-fluorouracil and leucovorin is extremely rare. To the best of our
knowledge, no case has been reported in the English literature. We report a
case and the relevant literature about the incidence, clinical picture and
possible pathophysiology on 5-fluorouracil-related cardioxicity is
reviewed.
相似文献
43.
44.
U Germing B Hildebrandt M Pfeilst?cker T N?sslinger P Valent C Fonatsch M Lübbert D Haase C Steidl O Krieger R Stauder A A N Giagounidis C Strupp A Kündgen T Mueller R Haas N Gattermann C Aul 《Leukemia》2005,19(12):2223-2231
The international prognostic scoring system (IPSS) is considered the gold standard for risk assessment in primary myelodysplastic syndromes (MDS). This score includes several prognostic factors except serum lactate dehydrogenase (LDH). We evaluated the prognostic power of LDH as an additional variable in IPSS-based risk assessment. For this purpose, a total of 892 patients with primary MDS registered by the Austrian-German cooperative MDS study group was analyzed retrospectively. Multivariate analysis confirmed the value of established parameters such as medullary blasts, karyotype and peripheral cell counts and showed that elevated LDH was associated with decreased overall survival (P<0.00005) and increased risk of AML development (P<0.00005), independent of the system used to classify MDS (FAB or WHO). Moreover, elevated LDH was found to be a significant predictor of poor survival within each IPSS risk group and within each FAB group except RAEB-T. To exploit these results for refined prognostication, each IPSS risk group was split into two separate categories (A=normal LDH vs B=elevated LDH). Using this LDH-assisted approach, it was possible to identify MDS patients with unfavorable prognosis within the low and intermediate IPSS risk groups. We propose that the IPSS+LDH score should improve clinical decision-making and facilitate proper risk stratification in clinical trials. 相似文献
45.
Marcel JH Aries Adnan Aslan Jan Willem J Elting Roy E Stewart Jan G Zijlstra Jacques De Keyser Patrick CAJ Vroomen 《Journal of clinical nursing》2012,21(13-14):1825-1830
Background. Routine lateral turning of patients has become an accepted standard of care to prevent complications of immobility. The haemodynamic and oxygenation effects for patients in both lateral positions (45°) are still a matter of debate. We aimed to study the effect of these positions on blood pressure, heart rate and oxygenation in a general intensive care population. Design. Observational study. Method. Twenty stable intensive care unit patients had intra‐arterial blood pressure recordings in the supine and lateral positions with the correction of hydrostatic height compared with a fixed reference point (phlebostatic level). A multilevel model was used to analyse the data. Results. Mean arterial pressure readings in the lateral positions were, on average, 5 mmHg higher than in the supine position (p < 0·001). There were no significant differences between mean arterial pressure recordings in the left and right lateral position (p = 1·0). No important differences in oxygenation and heart rate were observed. After correction for covariates, the effects persisted. Conclusion. Our study demonstrated an increase, albeit small, in blood pressure in the lateral positions. No major differences between the left and right lateral position were found. No important differences in oxygenation and heart rate were observed. Relevance to clinical practice. Turning haemodynamically stable patients in the intensive care unit has no important effects on blood pressure measurements when continuous hydrostatic height correction is applied. 相似文献
46.
Farhana Shariff Danielle Bischof Anand Govindarajan Rebecca Prince Ronald Burkes Erika Haase Lloyd Mack Walley Temple Pamela Hebbard Cindy Boulanger-Gobeil Carman Giacomantonio Alexandre BrindAmour Lucas Sidris Pierre Dub Trevor Hamilton Andrea MacNeill Antoine Bouchard-Fortier Rami Younan Andrea McCart 《Current oncology (Toronto, Ont.)》2021,28(1):40
Background: The COVID-19 pandemic has put enormous pressure on hospital resources, and has affected all aspects of patient care. As operative volumes decrease, cancer surgeries must be triaged and prioritized with careful thought and attention to ensure maximal benefit for the maximum number of patients. Peritoneal malignancies present a unique challenge, as surgical management can be resource intensive, but patients have limited non-surgical treatment options. This review summarizes current data on outcomes and resource utilization to help inform decision-making and case prioritization in times of constrained health care resources. Methods: A rapid literature review was performed, examining surgical and non-surgical outcomes data for peritoneal malignancies. Narrative data synthesis was cross-referenced with relevant societal guidelines. Peritoneal malignancy surgeons and medical oncologists reviewed recommendations to establish a national perspective on case triage and mitigating treatment strategies. Results and Conclusions: Triage of peritoneal malignancies during this time of restricted health care resource is nuanced and requires multidisciplinary discussion with consideration of individual patient factors. Prioritization should be given to patients where delay may compromise resectability of disease, and where alternative treatment options are lacking. Mitigating strategies such as systemic chemotherapy and/or surgical deferral may be utilized with close surveillance for disease stability or progression, which may affect surgical urgency. Unique hospital capacity, and ability to manage the complex post-operative course for these patients must also be considered to ensure patient and system needs are aligned. 相似文献
47.
48.
SB Cho JH Kim S Cho JM Park YK Park SH Oh 《Journal of the European Academy of Dermatology and Venereology》2011,25(1):64-67
Background The clinical characteristics of vitiligo in children and adolescents with an emphasis on thyroid dysfunction have only been reported in a few studies. Objective The purpose of this study was to examine the characteristics of children and adolescents with vitiligo and compare the incidence of thyroid dysfunction between them and controls without vitiligo at the same age. Methods A retrospective analysis of 324 Korean children and adolescents with vitiligo was performed. The results of thyroid function screening tests in them (n = 254) were compared with controls (n = 122). Results Of the total 324 children and adolescents with vitiligo, vitiligo vulgaris was the most common type (42.3%) and the most commonly involved site was the face (54.6%). A total of 15 of 254 (5.9%) patients screened for thyroid function were diagnosed with thyroid disease (four had Hashimoto’s thyroiditis; two, Graves’ disease; seven, subclinical hypothyroidism; and two, subclinical hyperthyroidism). None of the 50 patients with segmental vitiligo showed any thyroid dysfunction (P = 0.047). There was no significant difference in the incidence of thyroid disease between children and adolescents with vitiligo and the control group, in which seven of 122 (5.7%) showed thyroid dysfunction. Conclusion In this study, we demonstrated the characteristics of children and adolescents with vitiligo and also observed no significant difference in the incidence of thyroid disease between children and adolescents with vitiligo and the control group. 相似文献
49.
50.