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排序方式: 共有336条查询结果,搜索用时 15 毫秒
61.
Marie Meeths MD Yenan T. Bryceson PhD Eva Rudd MD PhD Chengyun Zheng MD PhD Stephanie M. Wood PhD Kim Ramme MD PhD Karin Beutel MD Henrik Hasle MD Carsten Heilmann MD Kjell Hultenby PhD Hans‐Gustaf Ljunggren MD PhD Bengt Fadeel MD PhD Magnus Nordenskjöld MD PhD Jan‐Inge Henter MD PhD 《Pediatric blood & cancer》2010,54(4):563-572
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A randomized trial comparing TVT with TVT-O: 12-month results 总被引:1,自引:1,他引:0
Kirsi Rinne Eija Laurikainen Arre Kivelä Pauliina Aukee Teuvo Takala Antti Valpas Carl Gustaf Nilsson 《International urogynecology journal》2008,19(8):1049-1054
The aim of this randomized clinical trial was to compare the cure rate and the rate of complications of the tension-free vaginal tape (TVT) with those of the tension free vaginal tape obturator (TVT-O) procedure after one year of follow-up. The study was powered to show a ten per cent difference in cure rate and/or rate of complications. Of the initially treated 267 women 134 in the TVT group and 131 in the TVT-O group were evaluated. A cough stress test and a 24 h pad test were used as objective outcome measures. Subjective outcome was assessed by different condition-specific quality of life questionnaires and general health by the EQ-5D questionnaire. Objective cure rate was 95.5% in the TVT patients and 93.1% in TVT-O patients. Subjective cure rates showed significant improvement at one the year follow up in both groups. No significant differences in cure rates between groups were seen. The complication rate was equal in both groups. 相似文献
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Amadeus T. Heinz Martin Ebinger Anton Schönstein Jörg Fuchs Beate Timmermann Guido Seitz Christian Vokuhl Marc W. Münter Kristian W. Pajtler Sabine Stegmaier Thekla von Kalle Christian P. Kratz Jochen Rößler Gustaf Ljungman Thomas Klingebiel Ewa Koscielniak Monika Sparber-Sauer the Cooperative Weichteilsarkom Studiengruppe 《Pediatric blood & cancer》2023,70(7):e30363
Background
Outcome of relapsed disease of localized rhabdomyosarcoma remains poor. An individual treatment approach considering the initial systemic treatment and risk group was included in the Cooperative Weichteilsarkom Studiengruppe (CWS) Guidance.Methods
Second-line chemotherapy (sCHT) ACCTTIVE based on anthracyclines (adriamycin, carboplatin, cyclophosphamide, topotecan, vincristine, etoposide) was recommended for patients with initial low- (LR), standard- (SR), and high-risk (HR) group after initial treatment without anthracyclines. TECC (topotecan, etoposide, carboplatin, cyclophosphamide) was recommended after initial anthracycline-based regimen in the very high-risk (VHR) group. Data of patients with relapse (n = 68) registered in the European Soft Tissue Sarcoma Registry SoTiSaR (2009–2018) were retrospectively analyzed.Results
Patients of initial LR (n = 2), SR (n = 16), HR (n = 41), and VHR (n = 9) group relapsed. sCHT consisted of ACCTTIVE (n = 36), TECC (n = 12), or other (n = 15). Resection was performed in 40/68 (59%) patients and/or radiotherapy in 47/68 (69%). Initial risk stratification, pattern/time to relapse, and achievement of second complete remission were significant prognostic factors. Microscopically incomplete resection with additional radiotherapy was not inferior to microscopically complete resection (p = .17). The 5-year event-free survival (EFS) and overall survival (OS) were 26% (±12%) and 31% (±14%). The 5-year OS of patients with relapse of SR, HR, and VHR groups was 80% (±21%), 20% (±16%), and 13% (±23%, p = .008), respectively.Conclusion
Adapted systemic treatment of relapsed disease considering the initial risk group and initial treatment is reasonable. New treatment options are needed for patients of initial HR and VHR groups. 相似文献69.
Life of patients 10 years after a successful pediatric intestinal transplantation in Europe 下载免费PDF全文
Lorenzo Norsa Girish Gupte Esther Ramos Boluda Francisca Joly Olivier Corcos Jacques Pirenne Gustaf Herlenius Florence Lacaille 《American journal of transplantation》2018,18(6):1489-1493
A multicenter Europe‐wide single‐point study in intestinal transplantation (ITx) centers was conducted to identify and describe patients surviving for more than 10 years after ITx in childhood. The health and nutritional status, care requirements and psychosocial status were recorded. Among 120 transplanted before 2005, 38 patients with a functioning graft were included. Thirty (79%) had an exclusive oral diet, seven (18%) complimentary enteral nutrition for eating disorders, and one a combination of parenteral and enteral nutrition. They received a median of five drugs daily and five had a stoma. We did not observe any catch‐up growth during the 10 years of follow‐up. In the previous five years, 22 patients needed unplanned hospitalization with a median in‐patient stay of six days. Eleven needed ongoing psychiatric follow‐ups, and nine needed other specialist follow‐ups. An increasing independency from parents was seen after the age of 18, with three having a stable employment and 31 pursuing education. Despite a good graft function, growth may not catch up. The burden of medical care remains high in the long term. This has to be closely followed in a multidisciplinary setting to improve long‐term quality of life in these patients. 相似文献
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