CT引导经皮穿刺治疗腰椎间盘突出症所致坐骨神经痛的疗效分析

目的 探讨CT引导下经皮穿刺治疗腰椎间盘突出症引起坐骨神经痛的疗效。方法 CT检查发现有腰椎间突出症伴明确临床体征75例,CT引导下经皮穿刺至相应椎间孔神经根处注射由得宝松、维生素B12和利我卡因组成混合药液,使药液分面到椎管内硬膜外。结果 CT引导穿刺注药成改善,9.3%治疗无效,症状无明显改善。结论 CT引导治疗腰椎间盘突出症所臻坐骨神经痛的方法是一种安全、可靠、有效且无并发症的新疗法,其无期疗效有待进一步观察。     

Pituicytoma with pleomorphism: A case report with cytological findings

Pituicytoma is a rare neoplasm, arising in the posterior pituitary or in the hypophyseal stalk, and its cytological findings have not yet been well-described. We have experienced a case of pituicytoma, which was difficult to diagnose intraoperatively, because of its cellular pleomorphism. A tumor measuring 18 mm in maximum diameter was found at the sella turcica in a Japanese woman in her forties. Both intraoperative crush cytology and histology of the resected tumor showed pleomorphic spindle or round cells, including multinucleated cells. Tumor cells were positive for TTF-1, S-100 protein, and vimentin, partially positive for glial fibrillary acidic protein and epithelial membrane antigen, and negative for synaptophysin, hormones of the anterior pituitary gland, CD34, Olig2, PAX8, and napsin A. Ki-67 labeling index was 2.0%. Tumors included in the differential diagnosis in general are pituitary adenoma, craniopharyngioma, germinoma, and metastatic tumor on the radiological standpoint, and pilocytic astrocytoma and meningioma on the cytological standpoint. However, our case was difficult to differentiate especially from high-grade glioma only by morphology, and immunohistochemistry including TTF-1 was helpful.