Porokeratosis Causing Change in Melanocytic Nevi

Large cell transformation of mycosis fungoides (MF) is an uncommon phenomenon. We present a case of CD30‐positive large cell transformation and discuss its possible pathophysiology. A 74 year‐old male with a 36‐year history of patch stage MF presented with a 3‐month history of right chest cellulitis that was refractory to IV antibiotic treatment. Skin biopsies from his thigh demonstrated a patchy dermal infiltrate of irregular and hyperchromatic lymphocytes and epidermotropism. The majority of the infiltrate was positive for CD4, CD3, CD2, and negative for CD7. Only 10% were positive for CD25 and CD8. Biopsies obtained from the ulcerated chest nodules showed a dermal infiltrate of large and pleomorphic lymphoid cells with prominent nucleoli. These large lymphoid cells were strongly positive for CD3, CD30, CD25, CD2 and UCHL‐1. Occasional cells were positive for CD4 and CD20. They were negative for ALK‐1, TIA‐1, CD7, CD8, and CD15. T‐gamma receptor gene rearrangement analyses by polymerase chain reaction demonstrated a clonal process with similar rearrangement patterns identified in the patch stage MF as well as in large cell transformation areas. Examinations of his peripheral blood and bone marrow were negative. The patient had tolerated one cycle of CHOP chemotherapy.     

Neuroleptic-induced tics in two hyperactive children

Two hyperactive boys who had developed motor and phonic tics during stimulant treatment reacted similarly to low doses of haloperidol and thioridazine. Neuroleptic-induced tics may be a consequence of presynaptic dopamine blockade.     

Methylphenidate and memory: Dissociated effects in hyperactive children

Fourteen children with Attention Deficit Disorder with Hyperactivity (ADD + H) were administered the psychostimulant methylphenidate in a double-blind, placebo-controlled, crossover study. Subjects were evaluated on a well-validated measure of verbal memory and learning with an experimental design comprised of four conditions: placebo and active drug at three doses. Positive memory effects were found in the drug conditions. Significant dose-response relationships were found, indicating enhanced learning from placebo to low to medium to high dose. However, there was a differential drug effect on the memory task; methylphenidate selectively enhanced storage and retrieval mechanisms without affecting immediate acquisition.Paper presented at the Fourteenth Annual Meeting of the International Neuropsychological Society. Denver, Colorado: February, 1986     

Improvement in the routine screening performance of cytotechnologists over time

BACKGROUND:

Documenting the performance of gynecologic screening in actual practice settings is difficult to achieve. In the current study, the screening performance of 11 individual cytotechnologists as well as that of the overall laboratory over 2 consecutive time periods was examined using the rapid prescreening (RPS) method.

METHODS:

RPS was performed by all cytotechnologists in a single laboratory over 2 separate 8‐month periods. The sensitivity of screening for individual and groups of cytotechnologists was examined. For purposes of comparison, cytotechnologists were divided into 2 groups: screeners with an overall routine sensitivity ≥95% and screeners with an overall sensitivity <95%.

RESULTS:

Atypical squamous cells (ASC) were used as a threshold, and routine screening sensitivity was found to vary from 68.3% to 96.8%. The overall sensitivity of the laboratory for RPS and routine screening was 43.6% and 88.4%, respectively. Over time, the overall laboratory sensitivity of routine screening improved from 85.3% to 91.3% (P = .01). During this same time frame, the sensitivity of the screeners with an overall sensitivity <95% improved from 79.3% to 91.2% (P < .001), whereas the sensitivity of screeners with an overall routine sensitivity ≥95% remained the same (96.1% to 96.4%; P = .6).

CONCLUSIONS:

In addition to improved overall performance of the laboratory by detecting and correcting errors, the results of the current study indicate that using RPS consistently over time might play a role leading to improved performance of cytotechnologists with an overall routine sensitivity <95% but not of cytotechnologists with an overall routine sensitivity ≥95%. Cancer (Cancer Cytopathol) 2009. © 2009 American Cancer Society.     

螺旋CT三维成像术-SSD的应用

目的：对三维成像技术SSD的临床应用进行探讨。材料与方法：开展SSD病人20例，其中男13例，女7例，年龄24－69岁，采用西门子Balance CT机，进行容积扫功，层厚2mm-4mm，螺距1－2，三维重建图像后处理采用SSD并采取多个角度观察，分析。结果：20例SSD检查成像良好。结论：SSD是非创伤性影像检查，具有安全、简便、价廉的优点，是一种适合临床广泛应用的影像检查方法。     

The impacts of abnormal color vision on people's life: an integrative review

Quality of Life Research - This article shows an integrative review on the impact that abnormal color vision may have on the daily routine of individuals. We followed the PRISMA guidelines for...     

纵隔低密度肿块病变CT诊断

目的：提高纵隔低密度肿块病变ＣＴ诊断水平。材料与方法：回顾性分析５１例经临床、手术及病理确诊纵隔低密度肿块变的ＣＴ表现。结果：（１）不同纵隔低密度肿块病变均有其较特定的发病部位;（２）含脂肪密度肿块病变包括囊性畸胎瘤,脂肪瘤 低密度肿块为包括囊性淋巴管瘤,胸腺囊肿,支气管囊肿,心包囊肿,神经纤维瘤囊性变,囊性畸胎瘤,椎旁脓肿;（４）含气及水样密度肿块包括食管癌术后胸腔内胃,食管憩室;（５）２例胸腺