全文获取类型
收费全文 | 1353篇 |
免费 | 84篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 44篇 |
妇产科学 | 11篇 |
基础医学 | 160篇 |
口腔科学 | 72篇 |
临床医学 | 129篇 |
内科学 | 276篇 |
皮肤病学 | 16篇 |
神经病学 | 186篇 |
特种医学 | 18篇 |
外科学 | 119篇 |
综合类 | 1篇 |
预防医学 | 73篇 |
眼科学 | 7篇 |
药学 | 187篇 |
中国医学 | 2篇 |
肿瘤学 | 135篇 |
出版年
2023年 | 5篇 |
2022年 | 17篇 |
2021年 | 29篇 |
2020年 | 15篇 |
2019年 | 16篇 |
2018年 | 18篇 |
2017年 | 29篇 |
2016年 | 20篇 |
2015年 | 21篇 |
2014年 | 35篇 |
2013年 | 65篇 |
2012年 | 80篇 |
2011年 | 84篇 |
2010年 | 36篇 |
2009年 | 51篇 |
2008年 | 89篇 |
2007年 | 87篇 |
2006年 | 95篇 |
2005年 | 88篇 |
2004年 | 92篇 |
2003年 | 82篇 |
2002年 | 94篇 |
2001年 | 40篇 |
2000年 | 33篇 |
1999年 | 35篇 |
1998年 | 15篇 |
1997年 | 16篇 |
1996年 | 12篇 |
1995年 | 14篇 |
1994年 | 8篇 |
1993年 | 10篇 |
1992年 | 18篇 |
1991年 | 12篇 |
1990年 | 12篇 |
1989年 | 11篇 |
1988年 | 6篇 |
1987年 | 6篇 |
1986年 | 10篇 |
1985年 | 3篇 |
1984年 | 6篇 |
1983年 | 4篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1973年 | 4篇 |
1972年 | 3篇 |
1971年 | 4篇 |
排序方式: 共有1444条查询结果,搜索用时 15 毫秒
61.
Violetta Insolia Erica C. Priori Caterina Gasperini Federica Coppa Marco Cocchia Erika Iervasi Beatrice Ferrari Roberta Besio Silvia Maruelli Graziella Bernocchi Antonella Forlino Maria G. Bottone 《The Journal of comparative neurology》2020,528(1):65-84
The extracellular matrix is essential for brain development, lamination, and synaptogenesis. In particular, the basement membrane below the pial meninx (pBM) is required for correct cortical development. The last step in the catabolism of the most abundant protein in pBM, collagen Type IV, requires prolidase, an exopeptidase cleaving the imidodipeptides containing pro or hyp at the C-terminal end. Mutations impairing prolidase activity lead in humans to the rare disease prolidase deficiency characterized by severe skin ulcers and mental impairment. Thus, the dark-like (dal) mouse, in which the prolidase is knocked-out, was used to investigate whether the deficiency of prolidase affects the neuronal maturation during development of a brain cortex area. Focusing on the cerebellar cortex, thinner collagen fibers and disorganized pBM were found. Aberrant cortical granule cell proliferation and migration occurred, associated to defects in brain lamination, and in particular in maturation of Purkinje neurons and formation of synaptic contacts. This study deeply elucidates a link between prolidase activity and neuronal maturation shedding new light on the molecular basis of functional aspects in the prolidase deficiency. 相似文献
62.
Zumel-Marne Angela Kundi Michael Castaño-Vinyals Gemma Alguacil Juan Petridou Eleni Th Georgakis Marios K. Morales-Suárez-Varela Maria Sadetzki Siegal Piro Sara Nagrani Rajini Filippini Graziella Hutter Hans-Peter Dikshit Rajesh Woehrer Adelheid Maule Milena Weinmann Tobias Krewski Daniel ′t Mannetje Andrea Momoli Franco Lacour Brigitte Mattioli Stefano Spinelli John J. Ritvo Paul Remen Thomas Kojimahara Noriko Eng Amanda Thurston Angela Lim Hyungryul Ha Mina Yamaguchi Naohito Mohipp Charmaine Bouka Evdoxia Eastman Chelsea Vermeulen Roel Kromhout Hans Cardis Elisabeth 《Journal of neuro-oncology》2020,147(2):427-440
Journal of Neuro-Oncology - We used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors (BTs), to study clinical characteristics of the tumors in... 相似文献
63.
Onofrio Caputi Iambrenghi Ippazio Ugenti Gennaro Martines Fabio Marino Donato Francesco Altomare Vincenzo Memeo 《International journal of colorectal disease》2009,24(7):749-753
Objectives The optimal treatment for large colorectal polyps (LCPs) is still a controversial issue. The aim of this study was to evaluate
the safety and effectiveness of endoscopic polypectomy (EP) of colorectal polyps ≥2 cm in size.
Patients and methods One hundred fifty-one EP LCPs were performed over a period of 7 years. Diathermal snare was used for pedunculated and pseudopedunculated
polyps and endoscopic mucosal resection (EMR) or biopsy forceps polypectomy for sessile and flat polyps. The resected polyps
were recovered and collected for histology. At scheduled follow-up visits 1, 3, 6, and 12 months after polypectomy, complications
and recurrences were recorded in all patients.
Results Fifteen polyps were located in the rectum, 84 in the sigmoid colon, 11 in the descending colon, four in the splenic flexure,
11 in the transverse colon, 11 in the hepatic flexure, seven in the ascending colon and eight in the cecum. Fifty-six polyps
were sessile, 54 pedunculated, 25 pseudopedunculated, and 16 flat. At histology, most of polyps (131) were adenomas (nine
with adenocarcinoma in situ). Five were invasive polypoid carcinomas and required colonic resection. Immediate bleeding occurred
in ten patients (7.6%) and it was stopped by endoscopic hemoclips (7), epinephrine injection (1), or surgery (2). There were
three perforations (2.3%; all polypoid carcinomas), managed endoscopically (1) or surgically (2). Delayed bleeding occurred
in two patients (1.5%) and was treated by endoscopic diathermy and hemoclips (1) or surgery (1). During follow-up, six (4.6%)
incompletely excised polyps and three (2.3%) relapses in the site of previous EP were detected and endoscopically removed.
Conclusion EP is relatively safe and effective for benign-appearing LCPs. 相似文献
64.
65.
Edna Aparecida Ferraz de Araújo Navas Aline Cássia Inocêncio Janete Dias Almeida Graziella Nuernberg Back-Brito Adolfo José Mota Antonio Olavo Cardoso Jorge Silvia Maria Rodrigues Querido Ivan Balducci Cristiane Yumi Koga-Ito 《Journal of oral pathology & medicine》2009,38(10):764-767
Objective: The aim of this study was to evaluate the prevalence of Candida spp. and presence of oral lesions in Brazilian leprosy patients under multidrug therapy (MDT).
Methods: Thirty-eight individuals (18 males and 20 females, median age 53 years) clinically and microbiologically diagnosed as leprosy (lepromatous variant), and under MDT for at least 45 days were studied. The control group constituted by 38 healthy individuals (median age 53.5), matched to the test group in relation to age, gender and oral conditions. Oral rinses were collected and the Candida identification was performed by phenotypic tests. The existence of Candida dubliniensis among the isolates was analyzed using a validated multiplex PCR assay. Twenty-nine leprosy patients were examined intra-orally for the presence of lesions. Data were analyzed by z- and Mann–Whitney tests (α = 5%).
Results: Yeast carriage rate between leprosy patients (65.8%) and controls (47.4%) was similar ( P = 0.099), and no significant difference between yeast counts was observed ( P = 0.1004). Candida albicans was the most frequently isolated species in both groups. In the leprosy group, Candida tropicalis and Candida parapsilosis were also identified. In the control group, we additionally identified Candida tropicalis , Candida glabrata and Candida kefyr. Candida dubliniensis was not detected. No leprosy-related oral lesion was registered.
Conclusion: Within the limits of the study, we concluded that Brazilian leprosy patients under MDT showed similar levels of carriage and Candida species distribution in relation to the controls. 相似文献
Methods: Thirty-eight individuals (18 males and 20 females, median age 53 years) clinically and microbiologically diagnosed as leprosy (lepromatous variant), and under MDT for at least 45 days were studied. The control group constituted by 38 healthy individuals (median age 53.5), matched to the test group in relation to age, gender and oral conditions. Oral rinses were collected and the Candida identification was performed by phenotypic tests. The existence of Candida dubliniensis among the isolates was analyzed using a validated multiplex PCR assay. Twenty-nine leprosy patients were examined intra-orally for the presence of lesions. Data were analyzed by z- and Mann–Whitney tests (α = 5%).
Results: Yeast carriage rate between leprosy patients (65.8%) and controls (47.4%) was similar ( P = 0.099), and no significant difference between yeast counts was observed ( P = 0.1004). Candida albicans was the most frequently isolated species in both groups. In the leprosy group, Candida tropicalis and Candida parapsilosis were also identified. In the control group, we additionally identified Candida tropicalis , Candida glabrata and Candida kefyr. Candida dubliniensis was not detected. No leprosy-related oral lesion was registered.
Conclusion: Within the limits of the study, we concluded that Brazilian leprosy patients under MDT showed similar levels of carriage and Candida species distribution in relation to the controls. 相似文献
66.
67.
68.
69.
Ottaná R Mazzon E Dugo L Monforte F Maccari R Sautebin L De Luca G Vigorita MG Alcaro S Ortuso F Caputi AP Cuzzocrea S 《European journal of pharmacology》2002,448(1):71-80
Within the series of chiral 3,3'-(1,2-ethanediyl)bis[2-arylthiazolidin-4-ones], the 3,4-dimethoxyphenyl substituted derivative was found in the primary anti-inflammatory screening to be endowed with superior in vivo properties and good safety profile. Such a lead compound was modified by eliminating 3-methoxy group while retaining 4-methoxy group on the aryl rings at 2 and 2' stereogenic carbons. The 2R,2'S-meso isomer (VIG3b) of the resulting bisthiazolidinone has been widely investigated. The inhibitory effects on cyclo-oxygenase-1 and cyclo-oxygenase-2 isoenzymes were measured in a human whole blood assay. VIG3b was almost 50 times more selective on the inducible isoform. The cyclo-oxygenase-2 preferential selectivity has been confirmed by modeling VIG3b into the cyclo-oxygenase-1 and cyclo-oxygenase-2 active sites. Furthermore, VIG3b was assayed in the experimental model of carrageenan-induced lung injury by evaluating its ability to inhibit: (1) fluid accumulation in the pleural cavity, (2) neutrophil infiltration, (3) prostaglandin E(2) production and (4) lung injury. VIG3b exhibited interesting activity in all these tests. 相似文献
70.