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101.
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M Zazzi R Kaiser A Sönnerborg D Struck A Altmann M Prosperi M Rosen‐Zvi A Petroczi Y Peres E Schülter CA Boucher F Brun‐Vezinet PR Harrigan L Morris M Obermeier C‐F Perno P Phanuphak D Pillay RW Shafer A‐M Vandamme K van Laethem AMJ Wensing T Lengauer F Incardona 《HIV medicine》2011,12(4):211-218
Objectives
The EuResist expert system is a novel data‐driven online system for computing the probability of 8‐week success for any given pair of HIV‐1 genotype and combination antiretroviral therapy regimen plus optional patient information. The objective of this study was to compare the EuResist system vs. human experts (EVE) for the ability to predict response to treatment.Methods
The EuResist system was compared with 10 HIV‐1 drug resistance experts for the ability to predict 8‐week response to 25 treatment cases derived from the EuResist database validation data set. All current and past patient data were made available to simulate clinical practice. The experts were asked to provide a qualitative and quantitative estimate of the probability of treatment success.Results
There were 15 treatment successes and 10 treatment failures. In the classification task, the number of mislabelled cases was six for EuResist and 6–13 for the human experts [mean±standard deviation (SD) 9.1±1.9]. The accuracy of EuResist was higher than the average for the experts (0.76 vs. 0.64, respectively). The quantitative estimates computed by EuResist were significantly correlated (Pearson r=0.695, P<0.0001) with the mean quantitative estimates provided by the experts. However, the agreement among experts was only moderate (for the classification task, inter‐rater κ=0.355; for the quantitative estimation, mean±SD coefficient of variation=55.9±22.4%).Conclusions
With this limited data set, the EuResist engine performed comparably to or better than human experts. The system warrants further investigation as a treatment‐decision support tool in clinical practice. 相似文献103.
Extensive nodular cutaneous amyloidosis: an unusual presentation 总被引:2,自引:0,他引:2
PR Criado†‡ CS Silva† C Vasconcellos†‡ NYS Valente† JB Maito† 《Journal of the European Academy of Dermatology and Venereology》2005,19(4):481-483
Amyloidosis is characterized by the deposition of a group of unrelated proteins leading to changes in tissue architecture and function. The nodular variant is the rarest form of the cutaneous amyloidoses. We report a patient with localized nodular amyloidosis without systemic amyloid involvement or paraproteinaemia after 6 years of follow-up. The unusual aspects of our case were a plaque presentation rather than nodular, and the disseminated pattern observed. 相似文献
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109.
The aim of this study was to determine the sensitivity and the localization
of pain from the internal female genital organs. In 28 women undergoing a
ring sterilization, the internal genital organs were pinched with a 3 mm
forceps and the pain sensitivity and localization were recorded. Pain
localization was vague, and pinching of the medial and distal end of the
oviduct, or of the anterior, posterior or left or right uterosacral
ligament could not be discriminated. The sensitivity of the pouch of
Douglas and of the uterosacrals was greater than of the oviduct, uterus or
ovaries. Small typical endometriotic lesions were specifically more
painful. The pain from the uterus was felt mainly in the hypogastric
region. The oviducts and ovaries radiated mainly to the iliac fossa,
whereas pain stimulation of the uterosacrals and pouch of Douglas was felt
predominantly in the perineal-perivulvar-perianal region. Radiation to the
lower back was rare and never occurred in isolation.
相似文献
110.