Incentives for recruiting trainee participants in medical education research

Introduction: In the growing field of medical education research, participant recruitment can be challenging. Incentives, either tangible or intangible, may be offered to encourage participation. This study aimed to understand these incentives and explore the relationship between study quality and incentives in medical education research.

Methods: We reviewed research studies examining medical trainees published in five major journals in 2008. Tangible and intangible incentives used in recruitment were extracted by two researchers. For each quantitative article, medical education research quality instrument (MERSQI) score was calculated and citation counts for all articles were compiled.

Results: Of 215 included articles, 8% explicitly reported incentives. Tangible incentives (value range $15–$60 USD) were offered in 7.9% of studies. Intangible incentives were identified in 30% of studies but only one specifically discussed their use. Tangible incentives correlated with a higher MERSQI score (p?p?Conclusion: Most studies in medical education did not describe incentives for participation. Information regarding incentives should be reported in all studies to help inform future recruitment efforts and also to understand the study context including factors that may influence participants motivation.     

Single-Molecule hsTnI and Short-Term Risk in Stable Patients With Chest Pain

Background

Evaluation of stable symptomatic outpatients with suspected coronary artery disease (CAD) may be challenging because they have a wide range of cardiovascular risk. The role of troponin testing to assist clinical decision making in this setting is unexplored.

A study with Bangladeshi women: Seeking care for breast health

In many low- and middle-income countries, breast cancer survival is low. Reasons for this are multifactorial, but delayed presentation for care is a common theme. In this survey study with 100 urban Bangladeshi women, we examined the role of socioeconomic and sociocultural factors on their likelihood to seek breast care from a family physician. In our multivariate model, a woman's age and education significantly predicted her likelihood to see a physician. Sociocultural aspects (e.g., concerns about time commitment of family members, personal household obligations) were significant at bivariate level. Findings are discussed in relation to practice, policy, and research.     

Selecting and Simplifying: Rater Performance and Behavior When Considering Multiple Competencies

Theory: Assessment of clinical competence is a complex cognitive task with many mental demands often imposed on raters unintentionally. We were interested in whether this burden might contribute to well-described limitations in assessment judgments. In this study we examine the effect on indicators of rating quality of asking raters to (a) consider multiple competencies and (b) attend to multiple issues. In addition, we explored the cognitive strategies raters engage when asked to consider multiple competencies simultaneously. Hypotheses: We hypothesized that indications of rating quality (e.g., interrater reliability) would decline as the number of dimensions raters are expected to consider increases. Method: Experienced faculty examiners rated prerecorded clinical performances within a 2 (number of dimensions) × 2 (presence of distracting task) × 3 (number of videos) factorial design. Half of the participants were asked to rate 7 dimensions of performance (7D), and half were asked to rate only 2 (2D). The second factor involved the requirement (or lack thereof) to rate the performance of actors participating in the simulation. We calculated the interrater reliability of the scores assigned and counted the number of relevant behaviors participants identified as informing their ratings. Second, we analyzed data from semistructured posttask interviews to explore the rater strategies associated with rating under conditions designed to broaden raters' focus. Results: Generalizability analyses revealed that the 2D group achieved higher interrater reliability relative to the 7D group (G = .56 and .42, respectively, when the average of 10 raters is calculated). The requirement to complete an additional rating task did not have an effect. Using the 2 dimensions common to both groups, an analysis of variance revealed that participants who were asked to rate only 2 dimensions identified more behaviors of relevance to the focal dimensions than those asked to rate 7 dimensions: procedural skill = 36.2%, 95% confidence interval (CI) [32.5, 40.0] versus 23.5%, 95% CI [20.8, 26.3], respectively; history gathering = 38.6%, 95% CI [33.5, 42.9] versus 24.0%, 95% CI [21.1, 26.9], respectively; ps < .05. During posttask interviews, raters identified many sources of cognitive load and idiosyncratic cognitive strategies used to reduce cognitive load during the rating task. Conclusions: As intrinsic rating demands increase, indicators of rating quality decline. The strategies that raters engage when asked to rate many dimensions simultaneously are varied and appear to yield idiosyncratic efforts to reduce cognitive effort, which may affect the degree to which raters make judgments based on comparable information.     

Total oxidant-scavenging capacities of plasma from glycogen storage disease type Ia patients as measured by cyclic voltammetry, FRAP and luminescence techniques

It has been suggested that the very low incidence of atherosclerosis in glycogen storage disease type Ia (GSD Ia) subjects might be attributed to elevated levels of uric acid, one of the potent low-molecular-weight antioxidants found in plasma. The present communication describes a use of two analytical methods—cyclic voltammetry and ferric reducing ability of plasma—and also two chemiluminescence methods to evaluate the total oxidant-scavenging capacities (TOSC) of plasma from GSD Ia patients. Our results verified the elevation of TOSC in GSD Ia patients and we propose the inclusion of luminescence and cyclic voltammetry assays as reliable methods for estimating TOSC in a variety of clinical disorders. Our findings with the cyclic voltammetry method add support to the assumption that the elevated uric acid levels might be the main contributor to plasma antioxidant capacity and possible protection against atherosclerosis.     

Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome

OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions.      

Effects of electroacupuncture on gastric mucosal blood flow and transmucosal potential difference in stress rats

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LL-37 Opsonizes and Inhibits Biofilm Formation of Aggregatibacter actinomycetemcomitans at Subbactericidal Concentrations

Host defense peptides are immediate responders of the innate immunity that express antimicrobial, immunoregulatory, and wound-healing activities. Neutrophils are a major source for oral host defense peptides, and phagocytosis by neutrophils is a major mechanism for bacterial clearance in the gingival tissue. Dysfunction of or reduction in the numbers of neutrophils or deficiency in the LL-37 host defense peptide was each previously linked with proliferation of oral Aggregatibacter actinomycetemcomitans which resulted in an aggressive periodontal disease. Surprisingly, A. actinomycetemcomitans shows resistance to high concentrations of LL-37. In this study, we demonstrated that submicrocidal concentrations of LL-37 inhibit biofilm formation by A. actinomycetemcomitans and act as opsonins and agglutinins that greatly enhance its clearance by neutrophils and macrophages. Improved uptake of A. actinomycetemcomitans by neutrophils was mediated by their opsonization with LL-37. Enhanced phagocytosis and killing of A. actinomycetemcomitans by murine macrophage-like RAW 264.7 cells were dependent on their preagglutination by LL-37. Although A. actinomycetemcomitans is resistant to the bactericidal effect of LL-37, our results offer a rationale for the epidemiological association between LL-37 deficiency and the expansion of oral A. actinomycetemcomitans and indicate a possible therapeutic use of cationic peptides for host defense.