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101.
Patrícia De Souza Rossignoli Oduvaldo CM Pereira Agnaldo B Chies 《Clinical and experimental pharmacology & physiology》2010,37(3):368-374
1. Orchidectomy results in long‐term testosterone deprivation similar to that observed in male clinical pathologies, such as hypogonadism and age‐related reductions in plasma testosterone concentrations. Although the vascular effects of these sorts of hormone deprivations are known in arteries, they have not been studied to the same extent in veins. 2. The aim of the present study was to determine the effect of orchidectomy, with or without subsequent testosterone replacement (started 23 days after orchidectomy; 10 mg/kg, i.m., testosterone propionate once every 5 days for 3 weeks), on responses of rat isolated portal veins and vena cavae to exogenous phenylephrine (PE). Isolated vessels were mounted in an organ bath and concentration–response curves constructed to PE (10?10–10?4 mol/L), endothelin (ET; 10?10–10?5 mol/L) and KCl (10?2–1.2 × 10?1 mol/L; as a control). 3. Orchidectomy had no effect on contractile responses of either the portal vein or vena cava to KCl. However, orchidectomy enhanced the maximum response (Rmax) of the portal vein, but not the vena cava, to PE. Testosterone replacement had no effect on these responses. The effects of orchidectomy on the Rmax to PE in portal veins were not altered by the nitric oxide synthase inhibitor NG‐nitro‐l‐ arginine methyl ester (10?4 mol/L) alone or combined with 10?5 mol/L indomethacin (a non‐selective cyclo‐oxygenase inhibitor), but they were abolished following treatment of isolated vessels with the ETA and ETB receptor antagonists BQ‐123 and BQ‐788 (both at 10?6 mol/L). Orchidectomy did not alter portal vein responses to the application of exogenous ET. 4. The results of the present study indicate that orchidectomy‐induced decreases in plasma testosterone can increase the venoconstrictor effects of PE on the portal vein and that this effect involves activation of both ETA and ETB receptors by locally produced ET. 相似文献
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Wallerian degeneration in the corticospinal tract was demonstrated by magnetic resonance (MR) imaging in a patient with Schilder disease. The histochemical stages of myelin breakdown that allow its demonstration by MR imaging are reviewed. 相似文献
105.
B. Byrne S. Cunningham R. Conroy T. J. McKenna J. Cox T. Cox R. England J. Walsh D. Coakley J. Feely E. O’Brien K. O’Malley Fidelma P. M. Dunne J. M. Gilvarry F. Keeling O. Fitzgerald J. F. Fielding D. Igoe M. J. Duffy M. J. Murphy Conleth F. Feighery C. P. Kelly R. B. Gallagher D. O’Neill M. Rowan D. Abraham J. B. Walsh J. J. O’Sullivan 《Irish journal of medical science》1989,158(9):242-244
106.
Gary Michael Dobson MD CM Dr Brian F. Horan MB BS Neil Thomas Bradburn MB BS 《Journal of clinical monitoring and computing》1992,8(1):62-65
We describe a patient undergoing elective surgery for treatment of an abdominal aortic aneurysm in whom an abrupt change in the contour of the pulmonary artery pressure (PAP) trace indicated the development of an intermediate (20 mm Hg) V wave in the pulmonary artery wedge pressure (PAWP) trace. As the PAP trace is displayed continuously, attention to its contour may allow for early detection of changes to the underlying PAWP trace.FC Anaesth 相似文献
107.
The fourth component of human complement (C4) is one that is essential to the antibody-mediated classical activation pathway. C4d, present on all normal and most patient red cells (RBCs), may be detected by the human antisera anti-Rodgers (Rg) and -Chido (Ch). A study has been made of the Rg/Ch antigens on normal and patient RBCs in an attempt to understand the mechanism by which C4 is bound to normal RBCs in the absence of RBC antibodies (Abs). Because RBCs from C1q-deficient patients express Rg/Ch, it seems that C1q is not essential for C4 binding. Treatment of normal RBCs with proteolytic enzymes, including trypsin, eliminated positive reactions with anti-Rg/Ch even though the C4d fragment is considered to be resistant to cleavage by trypsin. By correlating agglutination reactions with numbers of bound C4d and C3d molecules, it is evident that both C4d and C3d were affected by trypsin treatment and that anti-Rg/Ch were not capable of agglutinating RBCs with less than 50 molecules of bound C4d. It is concluded that trypsin-sensitive and -insensitive RBC membrane structures may both act as acceptors for C4. RBCs with null phenotypes of the major blood group systems all expressed Rg/Ch antigens, so none of the structures that carry these antigens act preferentially as acceptors for C4. 相似文献
108.
Trichinella infection and clinical disease 总被引:1,自引:0,他引:1
Clausen MR; Meyer CN; Krantz T; Moser C; Gomme G; Kayser L; Albrectsen J; Kapel CM; Bygbjerg IC 《QJM : monthly journal of the Association of Physicians》1996,89(8):631-636
Trichinellosis is caused by ingestion of insufficiently cooked meat
contaminated with infective larvae of <it>Trichinella</it>
species. The clinical course is highly variable, ranging from no apparent
infection to severe and even fatal disease. We report two illustrative
cases of trichinellosis. Returning to Denmark a few days after having eaten
roasted pork in the Republic of Serbia, a female patient suffered from
severe vomiting, epigastric pain, diarrhoea, and later myalgia, generalized
oedema, and prostration. A biopsy showed heavy infestation with
<it>Trichinella spiralis</it>, 2000 larvae/g of muscle.
Life-threatening cardiopulmonary, renal and central nervous system
complications developed. The patient recovered after several months. Her
husband, who also ate the pork, did not have clinical symptoms, but an
increased eosinophil count and a single larva in a muscle biopsy confirmed
infection. The epidemiology, clinical manifestations, diagnosis, treatment
and prevention of trichinellosis are reviewed.
相似文献
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