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Marital status, quality of life, and clinical outcome in patients with heart failure 总被引:2,自引:0,他引:2
Luttik ML Jaarsma T Veeger N van Veldhuisen DJ 《Heart & lung : the journal of critical care》2006,35(1):3-8
AIM: This study investigated the impact of having a partner on quality of life (QoL), the number of hospital readmissions, and 9-month survival in patients with heart failure (HF). METHODS: The study population consisted of hospitalized patients with HF. QoL was measured by the Cantril Ladder of Life (0-10) during hospital admission. Clinical data, readmission rate, and number of deaths were registered by patient interview and chart review. RESULTS: Of the 179 patients, 96 (54%) were married or were living with a partner. Differences in QoL between married patients and those living alone were most pronounced with regard to future expectations of QoL (6.5 vs 5.0, P=.00). However, in a multivariate model QoL was primarily associated with socioeconomic status, age, and gender. Married patients had 12% less events in the 9-month follow-up period compared with patients living alone (P=not significant). CONCLUSION: This study indicates that most patients with HF who are living alone are mostly elderly women with a low socioeconomic status, who are at risk for recurrent events and a worse QoL. 相似文献
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Charlotte L. Denholt Bertrand Kuhnast Frédéric Dollé Francoise Hinnen Paul R. Hansen Nic Gillings Andreas Kjær 《Journal of labelled compounds & radiopharmaceuticals》2010,53(13):774-778
There is growing interest in the use of radiolabelled peptides as receptor targeting agents for diagnostic imaging of various cancer types using positron emission tomography. In this work, 1‐[3‐(2‐[18F]fluoropyridin‐3‐yloxy)propyl]pyrrole‐2,5‐dione ([18F]FPyME) has been used for parallel fluorine‐18 labelling of PEPHC1, a peptide selective towards the cancer‐specific mutation of the epidermal growth factor receptor (EGFRvIII), and a number of truncated and mutated analogues. Conjugation of the peptides with [18F]FPyME was achieved within 10 min in non‐decay‐corrected radiochemical yields of 30–50%. The high yield of the conjugation reaction combined with its short synthesis time allows the labelling of several peptides from a single batch of [18F]FPyME. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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Attention to tracer dose principles is crucial in positron emission tomography (PET), and deviations can induce serious errors. In this study, we devise a method for determining receptor occupancy of the mass dose of the radioligand itself and the in vivo affinity.
Methods
The approach was used for [11C]SB207145, a new PET radioligand for imaging the cerebral 5-HT4 receptors in humans. Test–retest PET studies with varying specific activities of [11C]SB207145 were conducted in seven healthy subjects, and the output parameter regional BPND was modeled. Individual occupancy plots were first computed to estimate the mass dose that saturates 50% of receptors (ID50), and subsequently, the maximal mass dose that can be injected (arbitrarily set at an occupancy <5%) was calculated. Scatchard plots were computed to estimate the in vivo KD.Results
Increasing the mass dose resulted in a decrease in BPND, whilst the relative cerebellar uptake was unchanged. The ID50 was 85.4±30.2 μg, and the upper mass dose limit was 4.5±1.6 μg, which does not require ultrahigh specific activity. The estimated in vivo KD was 2.8 nM (range 1.0–4.8), without any regional differences.Conclusion
The presented method for estimating the upper mass dose limit is suggested as part of validation of PET radioligands. 相似文献87.
Mariane Sentenac Aoife Gavin Catherine Arnaud Michal Molcho Emmanuelle Godeau Saoirse Nic Gabhainn 《The Journal of adolescent health》2011,48(5):461-466
PurposeTo explore bullying victimization among French and Irish students with a disability or chronic illness (D/CI), considering individual, social, and family factors. We investigated this issue in France and Ireland because of the documented differences between these two countries on relevant contextual factors.MethodsData from 12,048 students aged 11, 13, and 15 years (50.1% were boys) as part of the cross-national study 2006 Health Behaviour in School-aged Children were analyzed. Self-completion questionnaires were administered in classrooms; information on socio-demographic characteristics, bullying involvement, D/CI, school participation, social network, and family were collected. Multivariate logistic regressions were performed with individual, social, and family cofactors.ResultsOverall, the prevalence of bullying victimization was significantly higher in France compared with Ireland (34.2% [33.1–35.5] and 25.9% [24.5–27.4, respectively]). Youngest were more likely to report victimization; however, no gender differences were observed. In both countries, students with D/CI were significantly more likely to report that they have been bullied compared with students without D/CI, and a significant additional risk of being bullied was found when students reported D/CI with restriction in school participation. Regardless of country and D/CI status, being bullied was significantly associated with weaker social support and difficulty of communication with fathers, with even stronger associations found among students with D/CI.ConclusionAdolescents with D/CI are more likely to be victimized than their peers, with a similar risk in both countries. Besides individual, social and family factors are consistently associated to bullying victimization across countries. These results will guide future antibullying prevention programs. 相似文献
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Maria Giouzeli Nic A Williams Lorne J Lonie Lynn E DeLisi Timothy J Crow 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2004,(1):1-9
Protocadherin X and Protocadherin Y (PCDHX and PCDHY) are cell-surface adhesion molecules expressed predominantly in the brain. The PCDHX/Y gene-pair was generated by an X-Y translocation approximately 3 million years ago (MYA) that gave rise to the Homo sapiens-specific region of Xq21.3 and Yp11.2 homology. Genes within this region are expected to code for sexually dimorphic human characteristics, including, for example, cerebral asymmetry a dimension of variation that has been suggested is relevant to psychosis. We examined differences in patients with schizophrenic or schizoaffective psychosis in the genomic sequence of PCDHX and PCDHY in coding and adjacent intronic sequences using denaturing high performance liquid chromatography (DHPLC). Three coding variants were detected in PCDHX and two in PCDHY. However, neither the coding variants nor the intronic polymorphisms could be related to psychosis within families. Low sequence variation suggests selective pressure against sequence change in modern humans in contrast to the structural chromosomal and sequence changes including fixed X-Y differences that occurred in this region earlier in hominid evolution. Our findings exclude sequence variation in PCDHX/Y as relevant to the aetiology of psychosis. However, we note the unusual status of this region with respect to X-inactivation. Further investigation of the epigenetic control of PCDHX/Y in relation to psychosis is warranted. 相似文献
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O'Sullivan M Nic Suibhne T Cox G Healy M O'Morain C 《Irish journal of medical science》2008,177(2):131-134
Background Specific sub-groups of the population, such as older people, are at increased risk of poor vitamin D status. There is growing
evidence, however, that vitamin D insufficiency may be a more widespread problem.
Aim To determine the prevalence of vitamin D insufficiency in a group of healthy Irish adults.
Methods Serum 25-hydroxyvitamin D was measured by radioimmunoassay in 70 healthy Irish adults working in South Dublin.
Results Overall, half of the group (51%) had vitamin D insufficiency; this was more pronounced in wintertime, with prevalence rising
to 58%. Winter was a significant negative predictor of serum 25-OH D levels. Sixteen percent of the participants reported
taking a vitamin D-containing supplement (multivitamin), but this did not significantly influence the serum 25-OH D levels.
Conclusion Vitamin D insufficiency is not confined to “at-risk groups” and is likely to be prevalent in the general public in Ireland,
especially in wintertime. 相似文献
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