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12.
Thalidomide inhibits lipoarabinomannan-induced upregulation of human immunodeficiency virus expression. 总被引:1,自引:0,他引:1
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P K Peterson G Gekker M Bornemann D Chatterjee C C Chao 《Antimicrobial agents and chemotherapy》1995,39(12):2807-2809
Mycobacterium tuberculosis accelerates the progression of human immunodeficiency virus type 1 (HIV-1) infection. The results of this study, which show that thalidomide inhibits the upregulation of HIV-1 expression in U1 cells stimulated with mycobacterial lipoarabinomannans, support the rationale behind conducting controlled trials of this immunodeficiency agent with patients dually infected with HIV-1 and M. tuberculosis. 相似文献
13.
Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures 总被引:9,自引:0,他引:9
P K Peterson B M Sharp G Gekker P S Portoghese K Sannerud H H Balfour 《AIDS (London, England)》1990,4(9):869-873
Because morphine has been shown to alter the function of human T lymphocytes and monocytes, we postulated that morphine would promote the growth of HIV-1 in these cells. To test this hypothesis, a coculture assay was used consisting of phytohemagglutinin (PHA)-activated peripheral blood mononuclear cells (PBMC) from normal donors and PBMC which had been infected with a viral isolate from an asymptomatic patient, HIV-1AT. The growth of HIV-1AT, as reflected by the concentration of p24 antigen in coculture supernatants, was markedly increased in cocultures that contained morphine. A bell-shaped dose-response curve was observed with three- to fourfold increased growth at a morphine concentration of 10(-12) M. Augmentation of HIV-1AT growth by morphine required an interaction with the PHA-activated donor PBMC. Furthermore, potentiation of HIV-1AT growth by morphine was stereospecific and was antagonized by naloxone and beta-funaltrexamine indicating involvement of an opiate receptor mechanism. These findings provide an additional explanation of how opiates could act as a cofactor in the pathogenesis of HIV-1 in intravenous drug users. 相似文献
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15.
Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells. 总被引:1,自引:0,他引:1
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J R Lokensgard G Gekker S Hu A F Arthur C C Chao P K Peterson 《Antimicrobial agents and chemotherapy》1997,41(11):2566-2569
Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B. 相似文献
16.
Gekker G Hu S Sheng WS Rock RB Lokensgard JR Peterson PK 《International immunopharmacology》2006,6(6):1029-1033
The neuropharmacological properties of cocaine are known to be associated with the activation of sigma-1 receptors. Cocaine also has been shown to alter both cytokine production and HIV-1 expression in mononuclear phagocytes, including microglial cells. This study tested the hypothesis that sigma-1 receptors and transforming growth factor (TGF)-beta1 are involved in cocaine-induced up-regulation of HIV-1 expression in microglial cell cultures. Treatment of microglial cells with cocaine resulted in a concentration-dependent increase in viral expression assessed by measurement of p24 antigen levels in culture supernatants. This cocaine-mediated stimulation of HIV-1 expression was blocked by treatment of microglia with inhibitors of sigma-1 receptors (BD1047) and TGF-beta1 (SB-431542 and anti-TGF-beta1 antibodies). Microglia were also shown to constitutively express sigma-1 receptor mRNA. Thus, the results of this study support the notion that neuroimmunopharmacological properties of cocaine involve sigma-1 receptors and cytokines. 相似文献
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Kogenta Nakamura Motoi Tobiume Masahiro Narushima Takahiko Yoshizawa Genya Nishikawa Yoshiharu Kato Remi Katsuda Kenji Zennami Shigeyuki Aoki Yoshiaki Yamada Nobuaki Honda Makoto Sumitomo 《BMC urology》2011,11(1):1-5
Background
There is no confirmed strategy for treating painful bladder syndrome/interstitial cystitis (PBS/IC) with unclear etiology. Therefore, a pilot study was carried out to evaluate the efficacy and safety of hyperbaric oxygen (HBO) therapy in treatment-resistant PBS/IC patients.Methods
HBO treatment (2.0 ATA for 60 minutes/day × 5 days/week for 2 or 4 weeks) was performed on 11 patients with severe symptoms that had not been improved by previous therapy regimens between December 2004 and July 2009.Results
Seven of the 11 patients demonstrated persistent improvement in symptoms during the 12 months after HBO treatment. These responders demonstrated a decrease in the pelvic pain scale and urgency scale from 7.7 ± 1.0 and, 6.6 ± 0.9 to 3.4 ± 2.5 and 4.3 ± 2.4 after 12 months, respectively (p < 0.05). The total score of the interstitial cystitis symptom index and 24-hour urinary frequency demonstrated a significant sustained decrease from the baseline. Two responders, who received an additional course of HBO 12 and 13 months after initial treatment, respectively, did not suffer impairment for more than two years. There was one case of transient eustachian tube dysfunction and three cases of reversible exudative otitis media as a consequence of HBO treatment.Conclusions
HBO is a potent treatment for PBS/IC patients resistant to conventional therapy. It was well tolerated and provided maintained amelioration of pain, urgency and urinary frequency for at least 12 months. 相似文献19.
20.
Yoshiaki Yamada Youko Itoh Shigeyuki Aoki Kogenta Nakamura Tomohiro Taki Katsuya Naruse Motoi Tobiume Kenji Zennami Remi Katsuda Yoshiharu Kato Masahito Watanabe Genya Nishikawa Miwako Minami Mariko Nakahira Sayaka Ukai Masaki Sawada Akiko Kitamura Nobuaki Honda 《Cancer chemotherapy and pharmacology》2009,64(6):1079-1083
Objective We evaluated the efficacy and safety of M-VAC chemotherapy combined with mild hyperthermia, a new therapeutic strategy for
advanced metastatic transitional cell carcinoma of the urothelium.
Subjects and methods The subjects were 12 patients diagnosed with advanced metastatic transitional cell carcinoma of the urothelium. For mild hyperthermia,
the patients’ oral temperature was elevated to about 38°C by heating for 20 min and retaining the heat for 20 min with a far-infrared
heater. The antitumor effect was evaluated according to the RECIST, while adverse drug reactions were assessed based on the
NCI-CTC.
Results The antitumor effect was rated as partial remission (PR) in 10 of the 12 patients and stable disease in 2 patients, with an
efficacy rate of 83% (10/12). All 10 patients who had achieved PR received three courses of treatment. Of the 12 patients,
5 died during the observation period, with survival for 9–23 months (mean: 15.6 months). Adverse drug reactions included myelosuppression
in all patients (Grade 3 in 4 patients, Grade 4 in 8), and gastrointestinal toxicity, such as nausea or vomiting, which was
mild (Grade 0 in 2 patients, Grade 1 in 8, Grade 2 in 1, Grade 3 in 1).
Conclusions The results of the present study suggest that M-VAC chemotherapy combined with mild hyperthermia, which potentiates the anticancer
effect and reduces adverse drug reactions such as gastrointestinal symptoms, is a useful and safe method for the treatment
of advanced transitional cell carcinoma of the urothelium. 相似文献