全文获取类型
收费全文 | 14292篇 |
免费 | 1326篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 189篇 |
儿科学 | 440篇 |
妇产科学 | 342篇 |
基础医学 | 1920篇 |
口腔科学 | 784篇 |
临床医学 | 1243篇 |
内科学 | 3345篇 |
皮肤病学 | 307篇 |
神经病学 | 1152篇 |
特种医学 | 748篇 |
外科学 | 1953篇 |
综合类 | 143篇 |
一般理论 | 5篇 |
预防医学 | 1139篇 |
眼科学 | 261篇 |
药学 | 759篇 |
中国医学 | 51篇 |
肿瘤学 | 883篇 |
出版年
2023年 | 53篇 |
2022年 | 146篇 |
2021年 | 333篇 |
2020年 | 234篇 |
2019年 | 375篇 |
2018年 | 474篇 |
2017年 | 346篇 |
2016年 | 373篇 |
2015年 | 415篇 |
2014年 | 540篇 |
2013年 | 658篇 |
2012年 | 881篇 |
2011年 | 853篇 |
2010年 | 588篇 |
2009年 | 506篇 |
2008年 | 694篇 |
2007年 | 791篇 |
2006年 | 665篇 |
2005年 | 639篇 |
2004年 | 540篇 |
2003年 | 489篇 |
2002年 | 436篇 |
2001年 | 357篇 |
2000年 | 332篇 |
1999年 | 355篇 |
1998年 | 198篇 |
1997年 | 177篇 |
1996年 | 160篇 |
1995年 | 136篇 |
1994年 | 140篇 |
1993年 | 132篇 |
1992年 | 238篇 |
1991年 | 211篇 |
1990年 | 185篇 |
1989年 | 236篇 |
1988年 | 195篇 |
1987年 | 171篇 |
1986年 | 173篇 |
1985年 | 162篇 |
1984年 | 125篇 |
1983年 | 105篇 |
1982年 | 64篇 |
1981年 | 76篇 |
1979年 | 80篇 |
1978年 | 68篇 |
1977年 | 52篇 |
1976年 | 53篇 |
1975年 | 61篇 |
1973年 | 56篇 |
1972年 | 46篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
61.
An epidural abscess due to resistant Staphylococcus aureus following epidural catheterisation 总被引:1,自引:0,他引:1
We report a case of abscess formation after epidural analgesia, a rare complication that developed in our patient 13 days after placement of a thoracic epidural catheter for patient controlled analgesia. Culture of the pus grew methicillin-resistant Staphylococcus aureus . Although early diagnosis and rapid management have been reported to yield a satisfactory outcome, the case we describe ended in severe sequelae. 相似文献
62.
63.
S Vidal M P Morante E Moga A M Mosquera S Querol J Garcia J l Rodriguez-Sanchez 《European journal of immunogenetics》2002,29(1):75-77
The DRB1* polymorphism in 941 randomly selected individuals from the Umbilical Cord Blood Bank of Barcelona (92.75% of Spanish origin) was determined by sequence-based typing. The HLA profile was similar to that of other Mediterranean populations, with DRB1*0701 and *0301 being the most frequent alleles. This may be a consequence of the mixture of alleles as a result of migration from contiguous geographical areas. 相似文献
64.
Melissa Hurwitz Manuel G Garcia Robert L Poole John A Kerner 《Nutrition in clinical practice》2004,19(3):305-308
The standard of care for patients with cholestasis (direct bilirubin >or=2 mg/dL) while receiving parenteral nutrition (PN) solutions is to reduce or discontinue the copper and manganese. The repercussions of this action have not been studied. Two adult case reports document low serum copper levels associated with clinical symptoms of copper deficiency after the removal of copper from their PN solutions. We now describe the first known series of pediatric patients to develop copper deficiency after copper was removed from their PN solutions. 相似文献
65.
Harry L June Rancia Cummings William J A Eiler Katrina L Foster Peter F McKay Regat Seyoum Marin Garcia Shannan McCane Collette Grey Stephanie E Hawkins Dynesha Mason 《Neuropsychopharmacology》2004,29(2):285-299
The exact opioid-sensitive receptors participating in EtOH-seeking behaviors remains unclear. Previous studies have reported higher densities of micro-opioid receptor binding in the nucleus accumbens (NACC) of P relative to NP rats; however, no differences were seen in delta-receptor binding. In contrast to the NACC, substantially lower levels of micro-receptor binding have been observed in the ventral tegmental area (VTA) of both P and NP rats, albeit no line differences have been observed. In the present study, opioid receptors in the NACC, VTA, and hippocampus were evaluated for their capacity to regulate both EtOH- and saccharin-motivated behaviors in the genetically selected alcohol-preferring (P) rat. To accomplish this, nalmefene, an opiate antagonist with preferential binding affinity for the micro-opioid receptor was unilaterally or bilaterally infused during concurrent availability of 1 h daily EtOH (10% v/v) and saccharin (0.025 or 0.050% w/v) solutions. Rats performed under a two-lever fixed ratio (FR) schedule in which four responses on one lever produced the EtOH solution, and four on a second lever produced the saccharin solution. The results demonstrated that when responding maintained by both EtOH and saccharin are matched at basal levels, unilateral (1-60 microg) or bilateral (0.5-10 microg) microinjections of nalmefene into the NACC produced selective dose-dependent reductions on responding maintained by EtOH. Unilateral (40, 60 microg) and bilateral (10 microg) VTA infusions were also observed to selectively reduced EtOH responding; however, greater nalmefene doses were required and the magnitude of suppression on EtOH responding was markedly less compared with the NACC. The greater sensitivity of nalmefene to suppress EtOH responding in the NACC is likely due to the greater number of opioid receptors in the NACC relative to the VTA. Only bilateral infusion of the 40 microg dose in the NACC and VTA suppressed responding maintained by both EtOH and saccharin. In contrast, intrahippocampal infusions dose dependently suppressed EtOH- and saccharin-maintained responding over a range of doses (1-20 microg). The present study provides evidence that nalmefene suppresses EtOH-motivated behaviors via blockade of opioid receptors within the NACC and VTA, and under various dose conditions both reinforcer and neuroanatomical specificity can be observed. 相似文献
66.
A Synergistic Effect Between PG490-88 and Tacrolimus Prolongs Renal Allograft Survival in Monkeys 总被引:2,自引:0,他引:2
G. Chen H. Sun J. Arp B. Garcia X. Wang Y. Wise W. Liu S. Ramcharran X. Huang Y. Xiang H. Yang Z. Fang J. Madenas Y. Sudo K. Tamura R. Zhong 《American journal of transplantation》2006,6(4):714-723
This study was undertaken to determine if PG490-88 and tacrolimus (Tac) act synergistically to prevent renal allograft rejection in monkeys and to explore possible mechanisms of synergy between these agents. MHC-mismatched renal allografts were transplanted into cynomolgus monkeys after bilateral nephrectomy. Recipients were divided into the following groups: (i) no treatment; (ii) PG490-88 (0.03 mg/kg); (iii) Tac (1 mg/kg); (iv) PG490-88 (0.01 mg/kg) + Tac (1 mg/kg) and (v) PG490-88 (0.03 mg/kg) + Tac (1 mg/kg). Through synergy PG490-88 and Tac inhibited anti-CD3/PMA-induced T-cell proliferation and IFN-gamma expression in vitro. Tac monotherapy only marginally prolonged survival (27 +/- 3.2 days), while the combination of PG490-88 and Tac significantly prolonged graft survival to a median of 99 days (PG490-88 at 0.03 mg) and 38.5 days (PG490-88 at 0.01 mg/kg). Prolonged survival correlated with inhibited IgM production as well as reduced T-cell infiltration, IL-2 protein expression and NF-AT/NF-kappaB activity. We conclude that PG490-88 and a subtherapeutic dose of Tac significantly prolong renal allograft survival in monkeys through the synergistic inhibition of T-cell activation and a decrease in IFN-gamma production and NF-AT/NF-kappaB activity. 相似文献
67.
IgA nephropathy and polycystic kidney disease 总被引:1,自引:0,他引:1
J M Panisello A Martinez-Vea C Garcia M Carrera J A Oliver C Richart 《American journal of nephrology》1988,8(6):477-478
We report a patient with polycystic kidney disease, advanced renal failure, and nephrotic-range proteinuria. Kidney biopsy revealed IgA nephropathy with lesions of focal and segmental glomerular sclerosis. This association had not been previously described and is probably coincidental. This case supports the assumption that the nephrotic-range proteinuria observed in some polycystic patients could be the consequence of another superimposed glomerular disease. This glomerulopathy can worsen the course of azotemia in these patients. 相似文献
68.
Status of iron nutrition along with demographic, anthropometric, dietary, and biochemical parameters were recorded in 98 pediatric cancer patients at the time of referral. Dietary intake in each patient was analyzed for calories, protein, and iron. Blood specimens were analyzed for hemoglobin (Hgb), hematocrit (Hct), iron, total iron-binding capacity (TIBC), transferrin, and ferritin. Dietary intake measures were assessed according to each subject's Recommended Dietary Allowance (RDA). The results were compared among three diagnostic groups, namely, benign, solid tumor, and hematopoietic. The nutrient lowest in intake was iron. The overall measures revealed significant differences between the benign and hematopoietic groups in all parameters except TIBC and transferrin. A correlation coefficient of 0.55 (p less than 10(-5) between transferrin and TIBC was generated in our patients. Significant differences were noted for ferritin in the acute lymphocytic leukemia (p = 0.0001) and lymphoma (p = 0.0007) groups when compared with the benign group. A correlation coefficient of 0.55 (p less than 10(-5) was generated in our patients. A 3-month follow-up assessment was conducted in order to document the effects of therapy. Tumor response and progression was compared to changes in ferritin levels from baseline to follow-up. Our results support the literature, that ferritin is a sensitive tumor marker in various malignancies. 相似文献
69.
郭永建 《福建医科大学学报》1994,(1)
采用间接ELISA检测23名肾移植受者血清巨细胞病毒(CMV)抗体,共检出18名(78%)活动性CMV感染,其中10名(44%)为原发性感染。结果证实CMV-IgE和-IgA具有较好的血清学诊断价值,优于CMV-IgM。 相似文献
70.