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排序方式: 共有2367条查询结果,搜索用时 31 毫秒
101.
Omar Asdrúbal Vilca Mejia Bruno Mahler Mioto Gabrielle Barbosa Borgomoni Juliana Mendanha Camilo Danielle Misumi Watanabe Sirlei Pereira Nunes Vanessa Santos Sallai Maraina Pegorini Librio de Lima Jurema da Silva Herbas Palomo Helenice Moreira da Costa Elisandra Trevisan Arita Maria Ignêz Zanetti Feltrim Vera Coimbra Roger Daglius Dias Filomena Regina Barbosa Gomes Galas Jos Otvio Costa Auler Junior Fabio Biscegli Jatene 《Arquivos brasileiros de cardiologia》2022,118(1):110
102.
Arjun Muralidharan Susana G. Sotocinal Noosha Yousefpour Nur Akkurt Lucas V. Lima Shannon Tansley Marc Parisien Chengyang Wang Jean-Sebastien Austin Boram Ham Gabrielle M.G.S. Dutra Philippe Rousseau Sioui Maldonado-Bouchard Teleri Clark Sarah F. Rosen Mariam R. Majeed Olivia Silva Rachel Nejade Xinyu Li Stephania Donayre Pimentel Christopher S. Nielsen G. Gregory Neely Chantal Autexier Luda Diatchenko Alfredo Ribeiro-da-Silva Jeffrey S. Mogil 《The Journal of clinical investigation》2022,132(8)
Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after nerve injury, male but not female mice displayed telomere length (TL) reduction and p53‑mediated cellular senescence in the spinal cord, resulting in maintenance of pain and associated with decreased lifespan. Nerve injury increased the number of p53‑positive spinal cord neurons, astrocytes, and microglia, but only in microglia was the increase male‑specific, matching a robust sex specificity of TL reduction in this cell type, which has been previously implicated in male‑specific pain processing. Pain hypersensitivity was reversed by repeated intrathecal administration of a p53‑specific senolytic peptide, only in male mice and only many months after injury. Analysis of UK Biobank data revealed sex-specific relevance of this pathway in humans, featuring male‑specific genetic association of the human p53 locus (TP53) with chronic pain and a male-specific effect of chronic pain on mortality. Our findings demonstrate the existence of a biological mechanism maintaining pain behavior, at least in males, occurring much later than the time span of virtually all extant preclinical studies. 相似文献
103.
Francois Rheault Kurt G. Schilling Alex ValcourtCaron Antoine Thberge Charles Poirier Gabrielle Grenier Guido I. Guberman John Begnoche Jon Haitz Legarreta Leon Y. Cai Maggie Roy Manon Edde Marco Perez Caceres Mario OcampoPineda Noor AlSharif Philippe Karan Pietro Bontempi Sami Obaid Sara Bosticardo Simona Schiavi Viljami Sairanen Alessandro Daducci Laurie E. Cutting Laurent Petit Maxime Descoteaux Bennett A. Landman 《Human brain mapping》2022,43(7):2134
The segmentation of brain structures is a key component of many neuroimaging studies. Consistent anatomical definitions are crucial to ensure consensus on the position and shape of brain structures, but segmentations are prone to variation in their interpretation and execution. White‐matter (WM) pathways are global structures of the brain defined by local landmarks, which leads to anatomical definitions being difficult to convey, learn, or teach. Moreover, the complex shape of WM pathways and their representation using tractography (streamlines) make the design and evaluation of dissection protocols difficult and time‐consuming. The first iteration of Tractostorm quantified the variability of a pyramidal tract dissection protocol and compared results between experts in neuroanatomy and nonexperts. Despite virtual dissection being used for decades, in‐depth investigations of how learning or practicing such protocols impact dissection results are nonexistent. To begin to fill the gap, we evaluate an online educational tractography course and investigate the impact learning and practicing a dissection protocol has on interrater (groupwise) reproducibility. To generate the required data to quantify reproducibility across raters and time, 20 independent raters performed dissections of three bundles of interest on five Human Connectome Project subjects, each with four timepoints. Our investigation shows that the dissection protocol in conjunction with an online course achieves a high level of reproducibility (between 0.85 and 0.90 for the voxel‐based Dice score) for the three bundles of interest and remains stable over time (repetition of the protocol). Suggesting that once raters are familiar with the software and tasks at hand, their interpretation and execution at the group level do not drastically vary. When compared to previous work that used a different method of communication for the protocol, our results show that incorporating a virtual educational session increased reproducibility. Insights from this work may be used to improve the future design of WM pathway dissection protocols and to further inform neuroanatomical definitions. 相似文献
104.
Perceptions of the Cause,Impact and Management of Persistent Fatigue in Patients with Rheumatoid Arthritis Following Tumour Necrosing Factor Inhibition Therapy
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105.
Brittany OwusuAdjei Charles Ogagan Jordan Smith Gabrielle Luiselli Mark D. Johnson 《Clinical Case Reports》2022,10(1)
Bacterial translocation as a mechanism of distal catheter infection may play a larger role in ventriculoperitoneal shunt infections than previously recognized. 相似文献
106.
Caitlin A. Gallo Gabrielle N. Desrochers Garett J. Morris Chad D. Rumney Sydney J. Sandell Jane K. McDevitt Dianne Langford John M. Rosene 《Journal of Sports Science and Medicine》2022,21(1):68
The purpose of this study was to assess changes in cervical musculature throughout contact-heavy collegiate ice hockey practices during a regular season of NCAA Division III ice hockey teams. In this cross-sectional study, 36 (male n = 13; female n = 23) ice hockey players participated. Data were collected over 3 testing sessions (baseline; pre-practice; post-practice). Neck circumference, neck length, head-neck segment length, isometric strength and electromyography (EMG) activity for flexion and extension were assessed. Assessments were completed approximately 1h before a contact-heavy practice and 15 min after practice. For sternocleidomastoid (SCM) muscles, males had significantly greater peak force and greater time to peak force versus females. For both left and right SCMs, both sexes had significantly greater peak EMG activity pre-practice versus baseline, and right (dominant side) SCM time to peak EMG activity was decreased post-practice compared to pre-practice. There were no significant differences for EMG activity of the upper trapezius musculature, over time or between sexes. Sex differences observed in SCM force and activation patterns of the dominant side SCM may contribute to head stabilization during head impacts. Our study is the first investigation to report changes in cervical muscle strength in men’s and women’s ice hockey players in the practical setting. Key points
- Concussion prevention strategies, such as cervical muscle strength and activation time, was investigated in the practical setting.
- Neck muscle fatigue may not be a contributing factor to a concussive event in contact sports such as ice hockey.
- Hand dominance may affect recruitment timing of neck musculature, which can affect the cervical muscle activation response.
- Males and females exhibited differences in sternocleidomastoid time to peak force.
107.
Thomas Wirth MD MSc Louise Laure Mariani MD PhD Gaber Bergant MD Michel Baulac MD PhD Marie-Odile Habert MD Nathalie Drouot MSc Emmanuelle Ollivier MSc Alenka Hodžić PhD Gorazd Rudolf MD Patrick Nitschke MSc Gabrielle Rudolf PhD Jamel Chelly MD PhD Christine Tranchant MD PhD Mathieu Anheim MD PhD Emmanuel Roze MD PhD 《Movement disorders》2020,35(5):880-885
108.
Calwing Liao BSc Faezeh Sarayloo MSc Daniel Rochefort MSc Gabrielle Houle BSc Fulya Akçimen MSc Qin He PhD Alexandre D. Laporte MSc Dan Spiegelman MSc Werner Poewe MD Daniela Berg MD Stefanie Müller PhD Franziska Hopfner MD PhD Günther Deuschl MD PhD Gregor Kuhlenbäeumer MD PhD Alex Rajput MD Patrick A. Dion PhD Guy A. Rouleau MD PhD 《Movement disorders》2020,35(7):1153-1162
109.
Larisa T. McLoughlin Zack Shan Kathryn M. Broadhouse Natalie Winks Gabrielle Simcock Jim Lagopoulos Daniel F. Hermens 《Human brain mapping》2020,41(6):1495-1504
There is a dearth of research that has investigated the neural correlates of cyberbullying, using task‐based functional magnetic resonance imaging (fMRI) and, specifically, in a real‐time context such as observing cyberbullying scenarios. This article presents pilot data from a novel protocol designed to undertake such research with the overall aim being to elucidate the neurobiological underpinnings of cyberbullying via task‐based fMRI (tb‐fMRI)) in passive cyberbystanders. Young adults (N = 32, 18 to 25 years old) viewed six negative (cyberbullying) and six neutral stimuli from the Cyberbullying Picture Series (CyPicS) while undergoing tb‐fMRI. Our results revealed 12 clusters of significantly greater blood‐oxygenation‐level‐dependent (BOLD) responses (family wise error corrected p FWE < .05) in participants when viewing cyberbullying stimuli compared to neutral stimuli, across a distributed network of regions including left and right middle temporal gyrus, default mode network hubs, left and right posterior cerebellum/vermis, and putamen. Further analysis also revealed greater BOLD response in females compared to males, as well as in those with no prior experience of cyberbullying compared to those with prior experience (despite gender), when viewing the cyberbullying stimuli compared to the neutral stimuli. These results bring us closer to understanding the neurobiological underpinnings that may be associated with cybervictim/bully status and outcomes. 相似文献