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121.
Miriam Nannette Ebert Gabriele Beyer-Sehlmeyer Ute Monika Liegibel Tanja Kautenburger Thomas Walter Becker Beatrice Louise Pool-Zobel 《Nutrition and cancer》2013,65(1-2):156-164
Butyrate, one of the major products of gut fermentation, is known to inhibit proliferation, induce apoptosis and differentiation, and increase phase II enzyme activities in tumor cells, whereas little information is available on protective effects in less-transformed colon cells. The aim of this study was to investigate whether the chemoprotective mechanism of glutathione S-transferase (GST) induction by butyrate could also play a role in earlier stages of colon carcinogenesis and whether chemoresistance of cells toward the endogenous genotoxic risk factor 4-hydroxy-2-nonenal (HNE) could be a consequence of butyrate treatment. As cell models, we used the human tumor cell lines HT29 and HT29 clone 19A, a differentiated subclone with properties resembling primary colon cells. We determined the expression of GSTP1 protein (enzyme-linked immunosorbent assay), the major GST in HT29, GSTP1 mRNA (Northern blotting), GST activity, intracellular glutathione, and total protein. The genotoxic impact of HNE (100-200 μM) was compared in butyrate-treated and nontreated cells using single-cell microgel electrophoresis. Our results show that GSTP1 mRNA, GSTP1 protein, GST activity, and total protein were increased (1.2- to 2.5-fold) and glutathione levels were maintained after 24- 72 h of incubation with 4 mM butyrate. Moreover, a marked reduction of HNE-induced genotoxicity was caused by preincubation with butyrate. Butyrate also induced the phosphorylation of extracellular signal-regulated kinases (ERK1/2, Western blotting) after 5-30 min, which indicates a regulation of GST expression by this signal pathway. Most effects were greater in HT29 parent cells than in clone cells. In conclusion, butyrate enhances expression of GST and other proteins in both cell lines, which leads to an enhanced chemoprotection, reducing the impact of HNE genotoxicity. Thus butyrate could play a role in early and later stages of cancer prevention by reducing exposure to relevant risk factors. 相似文献
122.
Ilaria Franzese MD Alessandra Francica MD Gabriele Pesarini MD Leonardo Gottin MD Flavio L. Ribichini MD Francesco Onorati MD PhD Giuseppe Faggian MD 《Journal of cardiac surgery》2020,35(8):2093-2096
Balloon rupture is an uncommon complication during balloon-expandable transcatheter aortic valve replacement (TAVR). We describe a balloon rupture and tearing with intraventricular entrapment complicating transapical-TAVR, as well as our bailout retrieval of the failed device. 相似文献
123.
Buyun Liu Yangbo Sun Guifeng Xu Linda G. Snetselaar Gabriele Ludewig Robert B. Wallace Wei Bao 《Journal of the Academy of Nutrition and Dietetics》2019,119(4):617-625
Background
Excess iron levels can induce oxidative stress and could therefore affect telomere attrition. However, little is known about the impact of body iron status on telomere length.Objective
Our aim was to examine the association between serum ferritin concentrations, an indicator of body iron status, and leukocyte telomere length in US adults.Design
We conducted a nationwide, population-based, cross-sectional study.Participants/setting
We used data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. We included 7,336 adults aged 20 years or older who had available data on serum ferritin levels and telomere length. High ferritin levels were defined as a serum ferritin level >200 ng/mL (449.4 pmol/L) in women and >300 ng/mL (674.1 pmol/L) in men. Low ferritin levels were defined as a serum ferritin level <30 ng/mL (67.4 pmol/L).Main outcome measures
Leukocyte telomere length was assayed using the quantitative polymerase chain reaction method.Statistical analyses
Linear regression with survey weights was performed to estimate the association between serum ferritin levels and telomere length.Results
The prevalence of adults with high and low serum ferritin levels was 10.9% and 17.6%, respectively. High ferritin levels were inversely associated with telomere length compared to normal ferritin levels. After adjustment for demographic, socioeconomic and lifestyle factors, body mass index, C-reactive protein, and leukocyte cell type composition, the β coefficient for log-transformed telomere length was –0.020 (standard error [SE]=0.009; P=0.047). The association was stronger in adults aged 65 years or older (β coefficient –0.081, SE=0.017; P<0.001) than in adults 20 to 44 years old (β coefficient –0.023, SE=0.019; P=0.24) or adults aged 45 to 64 years old (β coefficient 0.024, SE=0.015; P=0.10) (P for interaction 0.003). Low ferritin levels were not significantly associated with telomere length compared with normal ferritin levels.Conclusions
In a US nationally representative population, high body iron status was associated with shorter telomeres, especially in adults aged 65 years or older. 相似文献124.
125.
Acute‐phase response following full‐mouth versus quadrant non‐surgical periodontal treatment: A randomized clinical trial
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128.
Gabriele GIORGI Jose M. LEON-PEREZ Vincenzo CUPELLI Nicola MUCCI Giulio ARCANGELI 《Industrial health》2014,52(1):43-53
Work-related stress is becoming a significant problem in Italy and it is therefore
essential to advance the theory and methodology required to detect this phenomenon at
work. Thus, the aim of this paper is to propose a new method for evaluating stress at work
by measuring the discrepancies between employees’ perceptions of stress and their leaders’
evaluation of the stress of their subordinates. In addition, a positive impression scale
was added to determine whether workers might give socially desirable responses in
organizational diagnosis. Over 1,100 employees and 200 leaders within several Italian
organizations were involved in this study. Structural equation modeling was used to test
such new method for evaluating stress in a model of stress at work that incorporates
relationships among individual (positive impression), interpersonal (workplace bullying)
and organizational factors (working conditions, welfare culture, training). Results showed
that the leaders’ capacity to understand subordinates’ stress is associated with
subordinates’ psychological well-being since higher disagreement between self and leaders’
ratings was related to lower well-being. We discuss the implications of healthy leadership
for the development of healthy organizations. 相似文献
129.
130.
Posttraumatic stress is associated with increased body mass index (BMI) and rates of obesity. Black adults are at greater risk for obesity, trauma exposure, development of posttraumatic stress disorder, and comorbid sleep problems compared to White adults. Accordingly, Black adults with a history of trauma exposure may be at greater risk for elevated BMI associated with posttraumatic stress and insomnia. Multiple linear regression was used to examine race as a moderator of the relationship between posttraumatic symptoms and insomnia with BMI in a sample of Black and White trauma-exposed Veterans (N = 171), controlling for age and sex. There was a significant interaction of race with PTSD (p = 0.042) and insomnia symptoms (p = 0.045) on BMI. Simple slopes showed a significant positive association of posttraumatic stress and BMI among Black (p = 0.003), but not White Veterans (p = 0.590). Similarly, insomnia was significantly associated with greater BMI for Black (p = 0.023), but not White Veterans (p = 0.496). Posttraumatic stress and insomnia may play a particularly important role in the development of weight related health problems among Black Veterans. Early identification and treatment of these symptoms may reduce the risk of obesity among this vulnerable population. 相似文献