全文获取类型
收费全文 | 13407篇 |
免费 | 954篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 337篇 |
儿科学 | 655篇 |
妇产科学 | 393篇 |
基础医学 | 1609篇 |
口腔科学 | 421篇 |
临床医学 | 1283篇 |
内科学 | 2606篇 |
皮肤病学 | 211篇 |
神经病学 | 1351篇 |
特种医学 | 841篇 |
外科学 | 1440篇 |
综合类 | 219篇 |
一般理论 | 26篇 |
预防医学 | 1043篇 |
眼科学 | 387篇 |
药学 | 602篇 |
中国医学 | 9篇 |
肿瘤学 | 945篇 |
出版年
2021年 | 146篇 |
2020年 | 108篇 |
2019年 | 137篇 |
2018年 | 205篇 |
2017年 | 126篇 |
2016年 | 159篇 |
2015年 | 153篇 |
2014年 | 243篇 |
2013年 | 364篇 |
2012年 | 485篇 |
2011年 | 506篇 |
2010年 | 274篇 |
2009年 | 295篇 |
2008年 | 428篇 |
2007年 | 509篇 |
2006年 | 507篇 |
2005年 | 449篇 |
2004年 | 448篇 |
2003年 | 403篇 |
2002年 | 445篇 |
2001年 | 430篇 |
2000年 | 425篇 |
1999年 | 363篇 |
1998年 | 230篇 |
1997年 | 179篇 |
1996年 | 196篇 |
1995年 | 171篇 |
1994年 | 174篇 |
1993年 | 146篇 |
1992年 | 377篇 |
1991年 | 381篇 |
1990年 | 378篇 |
1989年 | 350篇 |
1988年 | 350篇 |
1987年 | 376篇 |
1986年 | 331篇 |
1985年 | 317篇 |
1984年 | 210篇 |
1983年 | 201篇 |
1982年 | 137篇 |
1981年 | 135篇 |
1980年 | 124篇 |
1979年 | 203篇 |
1978年 | 190篇 |
1977年 | 141篇 |
1976年 | 121篇 |
1975年 | 129篇 |
1974年 | 127篇 |
1973年 | 126篇 |
1972年 | 111篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
61.
62.
Kelvin L Chou Maria L Moro-De-Casillas Melissa M Amick Leora L Borek Joseph H Friedman 《Movement disorders》2007,22(3):411-414
We examined the relationship between testosterone levels, violent dreams, and REM sleep behavior disorder (RBD) in 31 men with Parkinson's disease (PD): 12 with clinical RBD and 19 without. All PD patients with clinical RBD experienced violent dreams, but none of the 19 non-RBD patients reported violent dreams. While dream content appears to be more aggressive in PD patients with clinical RBD, the presence of violent dreams or clinical RBD is not associated with testosterone levels in men with PD. 相似文献
63.
S G Friedman 《Surgery》1990,107(2):153-155
Duplex imaging has been widely embraced as a safe and an accurate means of interrogating the extracranial carotid vessels. One reason for this is its appearance as a risk-free diagnostic tool. We report the cases of two patients in whom transient ischemic attacks developed during duplex imaging--attacks that began soon after application of the ultrasound transducer to the cervical region, were identical to prior attacks, and ceased within seconds of removal of the transducer from the neck. The underlying cause of this complication is discussed as is its proper management. 相似文献
64.
Mitchell L. Halperin Efstratios Kasimatis Oded Friedman 《Transplantation reviews (Orlando, Fla.)》2004,18(2):103-110
A patient had the onset of a severe degree of metabolic alkalosis associated with a very large daily loss of diarrheal fluid. Because the expected acid-base disorder in this setting is metabolic acidosis, factors that could result in the markedly increased concentration of bicarbonate (HCO3−) in plasma (P
3) were sought. In our approach, there is an emphasis on electroneutrality, mass balance, a quantitative analysis, and the application of basic concepts in physiology at the bedside. We suggest that there were 3 major factors that could explain why the P
3 was so high. First, a severe degree of extracellular fluid volume contraction was probably the most important factor that raised her P
3. Second, there may have been an unusual way to have an electroneutral addition of HCO3− and removal of chloride ions from her extracellular fluid compartment. Third, the diarrheal fluid could have contained little HCO3− because of a down-regulated intestinal secretion of HCO3−. This analysis challenges the traditional pathophysiology of metabolic alkalosis. 相似文献
65.
66.
67.
Bruce Lubotsky Levin Dr.P.H. Robert M. Friedman Ph.D. Jack Zusman M.D. M.P.H. 《The Psychiatric quarterly》1988,59(2):83-87
The papers which follow are revised and expanded versions of presentations made at the Conference on Improving Florida's Services for the Mentally Ill: The Role of Psychiatry, held in Tallahassee, Florida on October 7–8, 1986, and organized by the Florida Mental Health Institute, University of South Florida. The conference was sponsored by the Florida Department of Health and Rehabilitative Services through the Committee on Public Psychiatry. The authors and their organizational affiliations are listed below 相似文献
68.
Israel Zelikovic Shermine Dabbagh Aaron L. Friedman David T. Uehling Russell W. Chesney 《Pediatric nephrology (Berlin, Germany)》1988,2(4):512-514
A boy aged 4.5 years with prune-belly syndrome (PBS) and associated urethral stenosis, oligohydramnios, imperforate anus and vesicosigmoid fustula is described. In contrast to the anticipated poor prognosis, vesicostomy and divided transverse colostomy performed after birth followed by prophylaxis of infection and bicarbonate supplementation have resulted in a good outcome. The vesicosigmoid fistula might have served in utero as a natural diversion protecting from pressure-induced renal damage. It is suggested that the main determinant of prognosis in PBS is the presence and degree of kidney dysplasia at birth as reflected by the neonatal renal function after performance of an indicated urinary diversion procedure rather than the presence of severe associated anomalies.Supported in part by grants from the National Institute of Health AM 37223-01 and the Medical School and Graduate School Research Committees of the University of Wisconsin and a Research Career Development Award KO4 AM 00421 (RWC), by the Pearl M. Stetler Foundation (SD) and by a National Kidney Foundation fellowship (IZ) 相似文献
69.
J. C. Delarue S. Friedman H. Mouriesse F. May-Levin H. Sancho-Garnier G. Contesso 《Breast cancer research and treatment》1988,11(2):173-178
Epidermal growth factor receptor (EGFR), determined by the Scatchard curve method, was found in 22 cases of a random series of 100 patients with breast carcinoma. Two groups of patients were identified, one (n = 16) with a low concentration (0–50 fm/mg protein) of EGFR but with a high affinity (Kd = 3.2 nM), and the other (n = 6) with a high concentration (90–210 fm/mg protein) of EGFR but with a lower affinity (Kd = 6.3 nM).A significant inverse relationship was found between the presence of EGFR and receptors for estrogen (p<0.001) and progesterone (p = 0.001). EGFR was found in no (0/8) tumors with Grade I histoprognostic grade, 17% (10/58) Grade II, and 38% (11/29) Grade III (p<0.05). EGFR is present therefore in poorly differentiated tumors and associated with other factors of poor prognosis. Ourin vivo analyses confirm results found in tissue culture derived from human breast carcinoma cells.With the technical assistance of J. Barraque. 相似文献
70.
Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts 总被引:1,自引:0,他引:1
S X Skapek O M Colvin O W Griffith D R Groothuis E V Colapinto Y Lee J Hilton G B Elion D D Bigner H S Friedman 《Biochemical pharmacology》1988,37(22):4313-4317
D-54 MG, a human glioma-derived continuous cell line growing as subcutaneous or intracranial xenografts in athymic mice, was found to be sensitive to the effects of D,L-buthionine-(SR)-sulfoximine, a selective inhibitor of gamma-glutamylcysteine synthetase. Intraperitoneal administration of one dose of buthionine sulfoximine (BSO, 5 mmol/kg) resulted in depletion of total intracellular glutathione to 57 and 47% of control 12 hr, and 73 and 23% of control 24 hr, after BSO in subcutaneous and intracranial xenografts respectively. Concurrent measurement of total glutathione in the contralateral (non-tumor-containing) cerebral hemisphere in mice bearing intracranial D-54 xenografts demonstrated insignificant depletion of glutathione. Multiple doses of BSO, at 12-hr intervals, resulted in further depletion to 27% (s.c.) and 16.5% (i.c.) of control 12 hr following the final dose of BSO. Quantitative analysis of BSO delivery to xenograft and contralateral brain tissue revealed transfer constants, K1, of 15.8-24.1 x 10(-3) and 2.4 x 10(-3) ml.g-1.min-1 for xenograft and "normal" brain respectively. This highly selective depletion of glutathione in neoplastic tissue versus surrounding non-neoplastic host tissue may have therapeutic implications for the rational use of chemotherapeutic and radiotherapeutic intervention. 相似文献