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Céline Ramdani Laurence Carbonnell Arnaud Rabat Cédric Meckler Boris Burle Thierry Hasbroucq Franck Vidal 《Biological psychology》2013
We studied the impact of sleep deprivation on action monitoring. Each participant performed a Simon task after a normal night of sleep and after 26 h of awakening. Reaction time (RT) distributions were analyzed and the sensitivity of the error negativity (Ne/Ne like) to response correctness was examined. 相似文献
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Christelle Dufour Stephanie Foulon Anne Geoffray Julien Masliah-Planchon Dominique Figarella-Branger Valerie Bernier-Chastagner Laetitia Padovani La Guerrini-Rousseau Cecile Faure-Conter Celine Icher Anne-Isabelle Bertozzi Pierre Leblond Tasnime Akbaraly Franck Bourdeaut Nicolas Andr Celine Chapp Pascale Schneider Emilie De Carli Pascal Chastagner Claire Berger Julien Lejeune Christine Soler Natacha Entz-Werl Marie-Bernadette Delisle 《Neuro-oncology》2021,23(7):1163
BackgroundHigh-risk medulloblastoma is defined by the presence of metastatic disease and/or incomplete resection and/or unfavorable histopathology and/or tumors with MYC amplification. We aimed to assess the 3-year progression-free survival (PFS) and define the molecular characteristics associated with PFS in patients aged 5–19 years with newly diagnosed high-risk medulloblastoma treated according to the phase II trial PNET HR+5.MethodsAll children received postoperative induction chemotherapy (etoposide and carboplatin), followed by 2 high-dose thiotepa courses (600 mg/m2) with hematological stem cell support. At the latest 45 days after the last stem cell rescue, patients received risk-adapted craniospinal radiation therapy. Maintenance treatment with temozolomide was planned to start between 1–3 months after the end of radiotherapy. The primary endpoint was PFS. Outcome and safety analyses were per protocol (all patients who received at least one dose of induction chemotherapy).ResultsFifty-one patients (median age, 8 y; range, 5–19) were enrolled. The median follow-up was 7.1 years (range: 3.4–9.0). The 3 and 5-year PFS with their 95% confidence intervals (95% CI) were 78% (65–88) and 76% (63–86), and the 3 and 5-year OS were 84% (72–92) and 76% (63–86), respectively. Medulloblastoma subtype was a statistically significant prognostic factor (P-value = 0.039) with large-cell/anaplastic being of worse prognosis, as well as a molecular subgroup (P-value = 0.012) with sonic hedgehog (SHH) and group 3 being of worse prognosis than wingless (WNT) and group 4. Therapy was well tolerated.ConclusionsThis treatment based on high-dose chemotherapy and conventional radiotherapy resulted in a high survival rate in children with newly diagnosed high-risk medulloblastoma. 相似文献
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Patrick Niccola? Lemlih Ouchchane Maurice Libier Fay?ale Beouche Monique Belon Jean-Marc Vedrinne Bilal El Drayi Laurent Vallet Franck Ruiz Céline Biermann Pascal Duchêne Claudine Chirat Sylvie Soule-Sonneville Christian Dualé Claude Dubray Pierre Schoeffler 《Canadian journal of surgery》2015,58(2):114-120
Background
A greater incidence of persistent pain after inguinal herniorrhaphy is suspected with the open mesh procedure than with laparoscopy (transabdominal preperitoneal), but the involvement of neuropathy needs to be clarified.Methods
We examined the cumulative incidence of neuropathic persistent pain, defined as self-report of pain at the surgical site with neuropathic aspects, within 6 months after surgery in 2 prospective subcohorts of a multicentre study. We compared open mesh with laparoscopy using different analysis, including a propensity-matched analysis with the propensity score built from a multivariable analysis using a generalized linear model.Results
Considering the full patient sample (242 open mesh v. 126 laparoscopy), the raw odds ratio for neuropathic persistent pain after inguinal herniorrhaphy was 4.3. It reached 6.8 with the propensity-matched analysis conducted on pooled subgroups of 194 patients undergoing open mesh and 125 undergoing laparoscopy (95% confidence interval 1.5–30.4, p = 0.012). A risk factor analysis of these pooled subgroups revealed that history of peripheral neuropathy was an independent risk factor for persistent neuropathic pain, while older age was protective.Conclusion
We found a greater risk of persistent pain with open mesh than with laparoscopy that may be explained by direct or indirect lesion of nerve terminations. Strategies to identify and preserve nerve terminations with the open mesh procedure are needed. 相似文献88.
Benoit Peyronnet Emmanuel Oger Zineddine Khene Gregory Verhoest Romain Mathieu Mathieu Roumiguié Jean-Baptiste Beauval Benjamin Pradere Alexandra Masson-Lecomte Christophe Vaessen Hervé Baumert Jean-Christophe Bernhard Nicolas Doumerc Stéphane Droupy Franck Bruyere Alexandre De La Taille Morgan Roupret Karim Bensalah 《World journal of urology》2015,33(11):1815-1820
89.
Michelle M. Gill John Ditekemena Aimé Loando Nana Mbonze Jo Bakualufu Rhoderick Machekano Cady Nyombe Marleen Temmerman Franck Fwamba 《AIDS and behavior》2018,22(3):860-866
This cluster-randomized study aimed to assess the Elombe (“Champion”) standard operating procedure (SOP), implemented by providers and Mentor Mothers, on HIV-positive pregnant women’s retention between first and second antenatal visits. Sixteen facilities in Kinshasa were randomly assigned to intervention (SOP) or comparison (no SOP). Effect of the SOP was estimated using relative risk. Women in comparison facilities were more likely to miss second visits (RR 2.5, 95% CI 1.05–5.98) than women in intervention facilities (30.0%, n = 27 vs. 12.0%, n = 9, p < 0.002). Findings demonstrate that a simple intervention can reduce critical early loss to care in PMTCT programs providing universal, lifelong treatment. 相似文献
90.
Endoglin is emerging as a pivotal component of the gateway for signaling by transforming growth factor-beta (TGF-beta) in vascular endothelial cells. Mutations in endoglin cause a rare vascular disorder in humans known as hereditary hemorrhagic telengiectasia (HHT). Although rare, in-depth analysis of mutant mice and mononuclear cells from the blood of patients with HHT have provided novel and exciting insights into how the vasculature is formed, maintained, and repaired during disease. Here, we review recent data on how endoglin is thought to function in endothelial cells and place it in the broader context of signaling by TGF-beta family members in vascular cells in general. We highlight where the controversies on underlying molecular mechanisms currently lie and indicate areas of present research focus. 相似文献