Radiographic verification of pedicle screw pilot hole placement using Kirshner wires versus beaded wires

STUDY DESIGN: Kappa statistics were used to compare the accuracy of two different techniques for verifying pedicle screw pilot hole placement in cadaveric vertebrae. OBJECTIVE: To determine whether clinicians radiographically detect misplaced pedicle screw holes with greater sensitivity and specificity when beaded wires rather than straight Kirschner wires are used. SUMMARY OF BACKGROUND DATA: Pedicle screws commonly are used in orthopedic surgery to obtain and maintain spinal stability. Pedicle screws are reportedly misplaced at a rate of 20% to 40%. Radiographic verification is commonly used to place pedicle screw pilot holes, but this technique is known to be less than 100% accurate. Computer-assisted techniques may allow more accurate screw placement, but these techniques require expensive equipment. METHODS: Pedicle screw pilot holes were drilled into 12 human lumbar and thoracic vertebrae. Some of the holes were misplaced deliberately so that they violated the pedicle walls. Lateral and posteroanterior radiographs of the vertebrae were evaluated by 13 experienced orthopedic spine surgeons and 3 inexperienced observers. At different times, the observers were shown radiographs depicting Kirschner wires or beaded wires placed in the pilot holes. Observers indicated whether they thought the pedicle screw pilot hole violated the pedicle. RESULTS: The sensitivity and specificity of using posteroanterior or lateral radiographs to detect misplaced pedicle screws were increased when beaded wires were placed in the pilot holes. CONCLUSIONS: Radiographic evaluation of beaded wires placed in pedicle screw pilot holes can be both sensitive and specific for misplaced screws. The highest sensitivity and specificity were found using posteroanterior radiographs.     

Osseous free tissue transfer in head and neck reconstruction

Large palatomaxillary and oromandibular defects have a dramatic impact on speech, deglutition, mastication, and cosmesis. Traditional methods of reconstruction, such as locoregional flaps, free bone grafts, alloplastic materials, and prosthetic devices, have difficulty providing meaningful aesthetic and functional reconstruction of these defects. This article discusses current concepts in the reconstruction of large composite palatomaxillary and oromandibular defects with an emphasis on the role of free tissue transfer, including the factors to be evaluated when choosing a method of reconstruction, indications for specific donor sites, and recent technical refinements.     

Balancing the equation: The significance of professional and lay perceptions in the promotion of cervical screening amongst minority ethnic women

Studies of minority ethnic women and cancer screening have, in the past, suffered from many theoretical and methodological weaknesses. In addition, no attempts have been made to study the complexity of the issue involved in the intercultural context, or the possible contribution of women's experiences to low uptake rates. In order to further our understanding of the issues, an alternative approach, participatory action research (PAR), was adopted to identify factors that might have contributed to the persistently low participation of minority ethnic women in the cervical screening programme, and address them collaboratively. This paper presents the key findings of the ‘problem identification' phase of the project. Using mainly the focus-group method, it explores both smear takers' and minority ethnic women's perceptions and experiences of cervical screening. Data suggest that there was a divergence in perceptions held by these groups regarding cervical screening, which contributed to negative experiences for both groups. There is also clear evidence of dysfunctional clinical communication arising from these differing perceptions. Opportunistic screening at post-natal examination adopted by many general practices appeared to have perpetuated the perceptions that the majority of minority ethnic women held about the purpose of the smear test. Compounded by language differences, the majority of women who had undergone smear testing understood neither the purpose of screening programme nor the procedure of the test. This has clear implications for promoting regular uptake, and more importantly for informed consent and choice.     

Chiari osteotomy and shelf augmentation in the treatment of hip dysplasia

The clinical and radiographic results of Chiari osteotomy and shelf augmentation for acetabular dysplasia in 30 hips were reported. The average age at operation was 17 years for Chiari osteotomy and 13.8 years for shelf augmentation. The mean follow-up was 7.1 years for Chiari osteotomy and 4.1 years for shelf augmentation. Of the 14 Chiari osteotomies, 12 had good results by Tonnis clinical grading and 2 had poor results. There were significant improvements in the radiographic parameters measured (p < 0.01). They included center-edge angle of Wiberg, the acetabular angle of Sharp, the percentage of femoral head coverage, and the "c/b" ratio. For the 16 shelf augmentations, there were 8 good, 2 fair, and 6 poor results. The radiographic parameters measured were also all significantly improved (p < 0.01). The final Severin grading of the hips were improved by both Chiari osteotomy and shelf augmentation.     

Regional muramyl tripeptide phosphatidylethanolamine administration enhances hepatic immune function and tumor surveillance

BACKGROUND: Immune status of the liver may affect growth of liver metastases. We analyzed the ability of muramyl tripeptide phosphatidylethanolamine (MTP-PE), an immunomodulatory bacterial cell wall analog, to stimulate Kupffer cells (KCs) and protect against tumor growth, with or without an immunosuppressive partial hepatectomy (PH). Impact of MTP-PE's route of administration on KC function was assessed. METHODS: Buffalo rats (n = 7 to 12/group) were treated with saline, 40 microg MTP-PE intraportally (portal) or intravenously (IV) and challenged with 5 x 10(5) hepatoma cells, and tumors counted on day 21. To assess MTP-PE's impact on KC stimulation in animals undergoing PH, a known stimulant of tumor cell growth, groups were treated with saline or MTP-PE and challenged with tumor and underwent 30% PH. KCs were harvested and analyzed for superoxide production. Statistical analysis was performed with Mann-Whitney U test or chi-square test. RESULTS: MTP-PE-treated animals had fewer tumor nodules than control animals (19 vs 184, P <.005). MTP-PE-portal animals had fewer nodules than MTP-PE-IV (2 vs 36, P <.05). MTP-PE treatment before PH resulted in fewer tumor nodules compared with control animals (192 vs 276, P <. 05). MTP-PE administration increased macrophage superoxide production (20.6 +/- 2 vs 11.9 +/- 1.1 nmol/10(6) cells, P <.005). CONCLUSIONS: MTP-PE improved KC function and decreased growth of microscopic tumor cells. MTP-PE's effects persist after an immunosuppressive hepatectomy. Portal administration was the most effective. MTP-PE administration may be useful as a neoadjuvant therapy for patients undergoing resection of liver malignancies.