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991.
Sawubona reprise: reflections on the European Society of Thoracic Surgeons Presidential Address 2022
Alessandro Brunelli Amerikos Argyriou Hasan Batirel Yolonda Colson Gail Darling Felix Fernandez Michael Gooseman Toni Lerut Daniela Molena Nuria Novoa Isabelle Opitz Kostas Papagiannopoulos G. Alexander Patterson Rene H. Petersen Janette Rawlinson Gaetano Rocco Brendon M. Stiles Javeria Tariq Gonzalo Varela 《Journal of thoracic disease》2023,15(1):204
992.
Theo F. Marins Maite Russo Erika C. Rodrigues Marina Monteiro Jorge Moll Daniel Felix Julia Bouzas Helena Arcanjo Claudia D. Vargas Fernanda TovarMoll 《Human brain mapping》2023,44(5):2039
Cross‐modal plasticity in blind individuals has been reported over the past decades showing that nonvisual information is carried and processed by “visual” brain structures. However, despite multiple efforts, the structural underpinnings of cross‐modal plasticity in congenitally blind individuals remain unclear. We mapped thalamocortical connectivity and assessed the integrity of white matter of 10 congenitally blind individuals and 10 sighted controls. We hypothesized an aberrant thalamocortical pattern of connectivity taking place in the absence of visual stimuli from birth as a potential mechanism of cross‐modal plasticity. In addition to the impaired microstructure of visual white matter bundles, we observed structural connectivity changes between the thalamus and occipital and temporal cortices. Specifically, the thalamic territory dedicated to connections with the occipital cortex was smaller and displayed weaker connectivity in congenitally blind individuals, whereas those connecting with the temporal cortex showed greater volume and increased connectivity. The abnormal pattern of thalamocortical connectivity included the lateral and medial geniculate nuclei and the pulvinar nucleus. For the first time in humans, a remapping of structural thalamocortical connections involving both unimodal and multimodal thalamic nuclei has been demonstrated, shedding light on the possible mechanisms of cross‐modal plasticity in humans. The present findings may help understand the functional adaptations commonly observed in congenitally blind individuals. 相似文献
993.
Chengsong Cui Felix Stern Nils Ellendt Volker Uhlenwinkel Matthias Steinbacher Jochen Tenkamp Frank Walther Rainer Fechte-Heinen 《Materials》2023,16(1)
Duplex stainless steel powders for laser additive manufacturing have not been developed extensively. In this study, the melts of a super duplex stainless steel X2CrNiMoCuWN25-7-4 (AISI F55, 1.4501) were atomized with different process gases (Ar or N2) at different atomization gas temperatures. The process gas N2 in the melting chamber leads to a higher nitrogen dissolution in the steel and a higher nitrogen content of the atomized powders. The argon-atomized powders have more gas porosity inside the particles than the nitrogen-atomized powders. In addition, the higher the atomization gas temperature, the finer the powder particles. The duplex stainless steel powders showed good processability during PBF-LB/M (Laser powder bed fusion). The gas entrapment in the powder particles, regardless of the gas chemistry and the gas content, appears to have a negligible effect on the porosity of the as-built parts. 相似文献
994.
T. Sonia Boender Wei Cai Madlen Schranz Theresa Kocher Birte Wagner Alexander Ullrich Silke Buda Rebecca Zllner Felix Greiner Michaela Diercke Linus Grabenhenrich 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2022,27(27)
BackgroundThe COVID-19 pandemic expanded the need for timely information on acute respiratory illness at population level.AimWe explored the potential of routine emergency department data for syndromic surveillance of acute respiratory illness in Germany.MethodsWe used routine attendance data from emergency departments, which continuously transferred data between week 10 2017 and 10 2021, with ICD-10 codes available for > 75% of attendances. Case definitions for acute respiratory infection (ARI), severe acute respiratory infection (SARI), influenza-like illness (ILI), respiratory syncytial virus infection (RSV) and COVID-19 were based on a combination of ICD-10 codes, and/or chief complaints, sometimes combined with information on hospitalisation and age.ResultsWe included 1,372,958 attendances from eight emergency departments. The number of attendances dropped in March 2020 during the first COVID-19 pandemic wave, increased during summer, and declined again during the resurge of COVID-19 cases in autumn and winter of 2020/21. A pattern of seasonality of respiratory infections could be observed. By using different case definitions (i.e. for ARI, SARI, ILI, RSV) both the annual influenza seasons in the years 2017–2020 and the dynamics of the COVID-19 pandemic in 2020/21 were apparent. The absence of the 2020/21 influenza season was visible, parallel to the resurge of COVID-19 cases. SARI among ARI cases peaked in April–May 2020 (17%) and November 2020–January 2021 (14%).ConclusionSyndromic surveillance using routine emergency department data can potentially be used to monitor the trends, timing, duration, magnitude and severity of illness caused by respiratory viruses, including both influenza viruses and SARS-CoV-2. 相似文献
995.
Mateusz Wo
niak Timo Torsten Schmidt Yuanhao Wu Felix Blankenburg Jakob Hohwy 《Human brain mapping》2022,43(12):3721
The question how the brain distinguishes between information about self and others is of fundamental interest to both philosophy and neuroscience. In this functional magnetic resonance imaging (fMRI) study, we sought to distinguish the neural substrates of representing a full‐body movement as one''s movement and as someone else''s movement. Participants performed a delayed match‐to‐sample working memory task where a retained full‐body movement (displayed using point‐light walkers) was arbitrarily labeled as one''s own movement or as performed by someone else. By using arbitrary associations we aimed to address a limitation of previous studies, namely that our own movements are more familiar to us than movements of other people. A searchlight multivariate decoding analysis was used to test where information about types of movement and about self‐association was coded. Movement specific activation patterns were found in a network of regions also involved in perceptual processing of movement stimuli, however not in early sensory regions. Information about whether a memorized movement was associated with the self or with another person was found to be coded by activity in the left middle frontal gyrus (MFG), left inferior frontal gyrus (IFG), bilateral supplementary motor area, and (at reduced threshold) in the left temporoparietal junction (TPJ). These areas are frequently reported as involved in action understanding (IFG, MFG) and domain‐general self/other distinction (TPJ). Finally, in univariate analysis we found that selecting a self‐associated movement for retention was related to increased activity in the ventral medial prefrontal cortex. 相似文献
996.
Jeremy D. Gale 《Advances in therapy》2009,26(5):519-530
Chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (C-IBS) are commonly reported gastrointestinal
(GI) disorders that have a major impact on health and quality of life. Patients experience a range of symptoms of which infrequency
of bowel movement is but one and report that straining, the production of hard stools, and unproductive urges are more bothersome
than stool infrequency. Additionally, in C-IBS, patients report abdominal pain and bloating as particularly troubling. Traditional
treatments, such as laxatives, are often ineffective, especially in more severe constipation over the long term. In a population-based
survey of constipation sufferers, half were not satisfied with their current treatment, due predominantly to poor efficacy.
5-Hydroxytryptamine receptor 4 (5-HT4) agonists stimulate GI motility and intestinal secretion, and tegaserod has demonstrated efficacy in improving bowel habit.
Tegaserod also improves constipationassociated symptoms including bloating, abdominal discomfort, stool consistency, and straining
in patients with both CIC and C-IBS. However, tegaserod has been withdrawn due to an association with serious adverse cardiovascular
effects. Further 5-HT4 receptor agonists, including prucalopride and TD-5108 are in development and show exciting results in clinical studies in
CIC patients, suggesting further product approvals are likely. Headache and diarrhea are the most commonly reported adverse
event with this class of agent. Recently a novel prosecretory agent has been approved for the treatment of both CIC and C-IBS.
Lubiprostone stimulates chloride secretion through activation of type-2 chloride channels, increasing intestinal secretion
and transit, and its use has been associated with improvements in bowel habit and symptoms of constipation. Nausea, diarrhea,
and headache are the most commonly reported adverse events. Linaclotide also stimulates intestinal chloride secretion, but
this molecule achieves this indirectly, through the activation of guanylate cyclase C. Data are emerging, but the efficacy
and safety profile of this agent in the treatment of CIC and C-IBS appears encouraging. 相似文献
997.
INTRODUCTION: The aim of our study was to analyse the role of adrenomedullin (AM) and endothelin-1 (ET-1) in the adaptation of the maternal vascular system in normotensive pregnancy. METHODS: Twenty-eight pregnant women, who were normotensive throughout the duration of their pregnancy, were recruited into the study. Plasma levels of AM and ET-1 at each trimester were measured and the AM/ET-1 ratio was calculated. RESULTS: Our experiment showed a significant decrease in plasma concentrations of AM in the first trimester for the study group (n=28) compared with the non-pregnant control group (n=16). There was also a significant decrease in plasma concentrations of ET-1 in all three trimesters (P<0.05) and a significant increase in the AM/ET-1 ratio in all three trimesters (P<0.05) for the study group compared with the control group. CONCLUSION: An alteration in vascular equilibrium between AM and ET-1, favouring AM, may be a reason why the physiological adaptation of the maternal vascular system to pregnancy occurs during normotensive pregnancy. 相似文献
998.
Lorenz Baerlocher Oliver Kretschmar Paul Harpes Urs Arbenz Felix Berger Walter Knirsch 《Clinical research in cardiology》2008,97(5):310-317
OBJECTIVES: Comparison of the results of branch pulmonary artery stenosis treated with balloon angioplasty (BA) or stent implantation (SI) in children. BACKGROUND: Branch pulmonary artery stenosis may be treated with BA or SI. METHODS: We compared the results of 147 interventions of branch pulmonary artery stenosis in 87 children (median age 3.6 years). Patients were treated during 1989-2000 with BA and during 2001-2004 with SI. Primary endpoints were acute complications and reintervention during follow up. Secondary variables were age, vessel diameter increase, acute success rate, balloon/vessel diameter ratio, pulmonary artery hypoplasia indices, and procedure related factors. RESULTS: The acute vessel diameter increase with BA (4.31 +/- 1.98 vs. 7.15 +/- 2.31 mm) and SI (3.71 +/- 1.58 vs. 6.97 +/- 2.68 mm) was significant within both groups (P < 0.001), but not between both groups. The reintervention rate was comparable between both groups, but median time to reintervention was shorter after SI in infants compared to BA. The balloon/vessel diameter ratio was on average higher in BA than the stent/vessel diameter ratio in SI (3.49 +/- 2.16 vs. 2.42 +/- 0.56; P < 0.05) and was a significant risk factor (P < 0.01) for the higher complication rate after BA (BA: 14.1% vs. SI: 4.8%). No mortality occurred in both groups. CONCLUSION: BA and SI are safe interventional catheter therapies of branch pulmonary artery stenosis. The immediate results of BA and SI are comparable. The higher complication rate after BA, especially in infants, was associated with a higher balloon/vessel diameter ratio. SI seems to be a safe permanent alternative with foreign material, but requires more reinterventions in infants due to its therapeutic strategy. 相似文献
999.
Objective To assess whether hyponatremia in acute neurological patients is associated with the syndrome of inappropriate antidiuretic
hormone secretion (SIADH) or with the cerebral salt-wasting syndrome (CSWS).
Design Clinical, controlled, prospective study.
Setting Department of intensive care of a tertiary care academic hospital.
Patients Forty acute neurological patients with hyponatremia suggesting SIADH or CSWS (20) or with normonatremia (20).
Interventions None.
Measurements and main results Measurement of clinical and biological variables. Measurement of blood, plasma, and red blood cell volumes to discriminate
SIADH and CSWS. Renal, adrenal and thyroid functions were normal in all patients. Average blood, plasma, and red blood cell
volumes were 54, 37 and 17 ml/kg in control patients and 54, 37 and 18 ml/kg in hyponatremic patients, respectively.
Conclusions The adequate blood volumes in hyponatremic patients confirm the diagnosis of SIADH and do not support the concept of CSWS.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
1000.
Husmann L Wiegand M Valenta I Gaemperli O Schepis T Siegrist PT Namdar M Wyss CA Alkadhi H Kaufmann PA 《The international journal of cardiovascular imaging》2008,24(5):511-518
Objective The aim of this study was to compare the diagnostic accuracy of myocardial perfusion imaging (MPI) by positron emission tomography
(PET) with the diagnostic accuracy of MPI by single photon emission computed tomography (SPECT) in two comparable patient
cohorts, using coronary angiography (CA) as the standard of reference. Methods A “SPECT-group” of 80 patients (15 female, 65 male; mean age 60 ± 9 years) and a “PET-group” of 70 patients (14 female, 56
male; mean age 57 ± 10 years) underwent a one day stress/rest examination either with attenuation-corrected 13N-ammonia PET or attenuation-corrected 201TlCl SPECT or 99mTc-hexakis-methoxy-isobutyl-isonitril (MIBI) SPECT. PET and SPECT results were semiquantitatively graded using a 6-segment
heart model. All patients underwent CA, and stenoses were graded as a diameter reduction ≥50%. Results Coronary findings between both groups did not significantly differ at CA. For the SPECT-group overall sensitivity and specificity
for localisation of stenoses was 77% and 84%. Respective values for the PET-group were 97% and 84%. The specificity of MPI
by SPECT in the detection of ischemia was 74% and 91% for MPI by PET. The diagnostic accuracy of MPI improves when the individual
coronary dominance and previous coronary revascularisations are taken into account. Conclusion MPI by 13N-ammonia PET is more sensitive in the detection and localisation of coronary stenoses, and more specific in the detection
of ischemia than MPI by 201TlCl/99mMIBI SPECT. 相似文献