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排序方式: 共有1313条查询结果,搜索用时 15 毫秒
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We hypothesized that decreasing elevated night‐time heart rate (HR) in hypertension by administering a bradycardic agent (ivabradine) at bedtime could bring cardiovascular benefit. Since rats are nocturnal animals, they exhibit circadian rhythms phase‐shifted relative to humans. Sixty‐six Wistar rats were divided into non‐diseased controls and rats with l ‐NAME‐induced hypertension to compare the haemodynamic effects of daytime‐dosed and night‐time‐dosed ivabradine. l ‐NAME‐induced hypertension inverted the physiological 5.6% night‐to‐day HR dip to an undesirable HR rise by 11.1%. Ivabradine dosed at daytime (the rat's resting phase) reverted a night‐to‐day HR rise to HR dip by 14.2%. These results suggest a cardiovascular benefit of ivabradine dosed at the human's resting phase (night‐time) for hypertensive patients with nondipping HR. 相似文献
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HH Wensink J Dunkel S Heidenreich K Drescher RE Goldstein H Löwen JM Yeomans 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(36):14308-14313
Turbulence is ubiquitous, from oceanic currents to small-scale biological and quantum systems. Self-sustained turbulent motion in microbial suspensions presents an intriguing example of collective dynamical behavior among the simplest forms of life and is important for fluid mixing and molecular transport on the microscale. The mathematical characterization of turbulence phenomena in active nonequilibrium fluids proves even more difficult than for conventional liquids or gases. It is not known which features of turbulent phases in living matter are universal or system-specific or which generalizations of the Navier-Stokes equations are able to describe them adequately. Here, we combine experiments, particle simulations, and continuum theory to identify the statistical properties of self-sustained meso-scale turbulence in active systems. To study how dimensionality and boundary conditions affect collective bacterial dynamics, we measured energy spectra and structure functions in dense Bacillus subtilis suspensions in quasi-2D and 3D geometries. Our experimental results for the bacterial flow statistics agree well with predictions from a minimal model for self-propelled rods, suggesting that at high concentrations the collective motion of the bacteria is dominated by short-range interactions. To provide a basis for future theoretical studies, we propose a minimal continuum model for incompressible bacterial flow. A detailed numerical analysis of the 2D case shows that this theory can reproduce many of the experimentally observed features of self-sustained active turbulence. 相似文献
35.
Tachycardia has been associated with worse outcomes for patients with heart failure and is also thought to have a direct adverse
impact on the myocardium. This report highlights the current evidence for heart rate as both a risk factor and mediator for
poor outcome for patients with heart failure. We summarize the large number of studies evaluating heart rate in patients with
systolic dysfunction and newer studies that examine patients with preserved systolic function. The effect on outcomes in heart
failure of medications known to slow the heart rate such as β-blockers and the more recently developed drug ivabradine are
discussed. The data clearly show that a high heart rate is a marker of increased mortality. There is also a strong suggestion
that a higher heart rate directly worsens outcome and that this can be mitigated by heart rate–reducing medications. 相似文献
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Marco Bandini Maarten Albersen Juan Chipollini Filippo Pederzoli Yao Zhu Ding-Wei Ye Antonio A. Ornellas Nick Watkin Michael Ager Oliver W. Hakenberg Axel Heidenreich Daniele Raggi Mario Catanzaro Friederike Haidl Elio Mazzone Laura Marandino Alberto Briganti Francesco Montorsi Mounsif Azizi Philippe E. Spiess Andrea Necchi 《BJU international》2020,125(6):867-875
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Guillaume Ploussard Alberto Briganti Alexandre de la Taille Alexander Haese Axel Heidenreich Mani Menon Tullio Sulser Ashutosh K. Tewari James A. Eastham 《European urology》2014