全文获取类型
收费全文 | 11183篇 |
免费 | 681篇 |
国内免费 | 102篇 |
专业分类
耳鼻咽喉 | 106篇 |
儿科学 | 221篇 |
妇产科学 | 309篇 |
基础医学 | 1432篇 |
口腔科学 | 445篇 |
临床医学 | 901篇 |
内科学 | 2785篇 |
皮肤病学 | 134篇 |
神经病学 | 951篇 |
特种医学 | 456篇 |
外科学 | 1881篇 |
综合类 | 34篇 |
预防医学 | 484篇 |
眼科学 | 119篇 |
药学 | 672篇 |
中国医学 | 31篇 |
肿瘤学 | 1005篇 |
出版年
2024年 | 8篇 |
2023年 | 82篇 |
2022年 | 227篇 |
2021年 | 382篇 |
2020年 | 221篇 |
2019年 | 324篇 |
2018年 | 400篇 |
2017年 | 272篇 |
2016年 | 329篇 |
2015年 | 391篇 |
2014年 | 592篇 |
2013年 | 648篇 |
2012年 | 948篇 |
2011年 | 960篇 |
2010年 | 517篇 |
2009年 | 498篇 |
2008年 | 758篇 |
2007年 | 774篇 |
2006年 | 639篇 |
2005年 | 640篇 |
2004年 | 636篇 |
2003年 | 507篇 |
2002年 | 409篇 |
2001年 | 62篇 |
2000年 | 48篇 |
1999年 | 67篇 |
1998年 | 72篇 |
1997年 | 70篇 |
1996年 | 56篇 |
1995年 | 50篇 |
1994年 | 57篇 |
1993年 | 50篇 |
1992年 | 27篇 |
1991年 | 37篇 |
1990年 | 26篇 |
1989年 | 25篇 |
1988年 | 23篇 |
1987年 | 15篇 |
1986年 | 18篇 |
1985年 | 10篇 |
1984年 | 13篇 |
1983年 | 9篇 |
1982年 | 9篇 |
1981年 | 8篇 |
1980年 | 5篇 |
1979年 | 6篇 |
1977年 | 5篇 |
1975年 | 6篇 |
1974年 | 5篇 |
1973年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
161.
162.
Licia Iaccarino Tiziana Ottone Valentina Alfonso Laura Cicconi Mariadomenica Divona Serena Lavorgna Serena Travaglini Aleandra Ferrantini Giulia Falconi Constance Baer Monica Usai Fabio Forghieri Adriano Venditti Maria Ilaria Del Principe William Arcese Maria Teresa Voso Torsten Haferlach Francesco Lo-Coco 《American journal of hematology》2019,94(10):1091-1097
Despite the high probability of cure of patients with acute promyelocytic leukemia (APL), mechanisms of relapse are still largely unclear. Mutational profiling at diagnosis and/or relapse may help to identify APL patients needing frequent molecular monitoring and early treatment intervention. Using an NGS approach including a 31 myeloid gene-panel, we tested BM samples of 44 APLs at the time of diagnosis, and of 31 at relapse. Mutations in PML and RARA genes were studied using a customized-NGS-RNA panel. Patients relapsing after ATRA-chemotherapy rarely had additional mutations (P = .009). In patients relapsing after ATRA/ATO, the PML gene was a preferential mutation target. We then evaluated the predictive value of mutations at APL diagnosis. A median of two mutations was detectable in 9/11 patients who later relapsed, vs one mutation in 21/33 patients who remained in CCR (P = .0032). This corresponded to a significantly lower risk of relapse in patients with one or less mutations (HR 0.046; 95% CI 0.011-0.197; P < .0001). NGS-analysis at the time of APL diagnosis may inform treatment decisions, including alternative treatments for cases with an unfavorable mutation profile. 相似文献
163.
164.
165.
166.
Gonzalo M. Quiones Ahmad Mayeli Victor E. Yushmanov Hoby P. Hetherington Fabio Ferrarelli 《Neuropsychopharmacology》2021,46(6):1133
Youth at clinical high risk (CHR) are a unique population enriched for precursors of major psychiatric disorders, especially schizophrenia (SCZ). Recent neuroimaging findings point to abnormalities in the thalamus of patients with SCZ, including chronic and early course patients, as well as in CHR individuals relative to healthy comparison groups, thus suggesting that thalamic dysfunctions are present even before illness onset. Furthermore, modeling data indicate that alteration between excitatory and inhibitory control, as reflected by alteration in GABAergic and glutamatergic balance (i.e., GABA/Glu), may underlie thalamic deficits linked to the risk and development of psychosis. There is, however, a lack of in vivo evidence of GABA/Glu thalamic abnormalities in the CHR state. Magnetic resonance spectroscopic imaging (MRSI) 7 Tesla (7 T) provides enhanced resolution to quantify GABA and Glu levels in the thalamus of CHR individuals. In this study, we performed 7 T MRSI in 15 CHR and 20 healthy control (HC) participants. We found that GABA/Glu was significantly reduced in the right medial anterior and right medial posterior thalamus of CHR relative to HC groups. The GABA/Glu reduction was negatively correlated with general symptoms in the right medial anterior thalamus, as well as with disorganization symptoms in the right medial posterior thalamus. Altogether, these findings indicate that GABA/Glu abnormalities are present in the thalamus before the onset of full-blown psychosis and are associated with symptom severity, thus providing putative molecular and neuronal targets for early interventions in youth at CHR.Subject terms: Predictive markers, Psychosis, Neuroscience, Risk factors 相似文献
167.
Fabio Santanelli Marco Mazzocchi Luca Renzi Emanuele Cigna 《Journal of plastic surgery and hand surgery》2013,47(3):183-185
Based on the assumption that the umbilicus is a wound that has healed by second intention, we describe a method of reconstruction. The procedure consists of complete resection of the umbilical scar and its reconstruction by a linear incision at the site of the new umbilicus and inversion of the skin hedges, which are sutured to the linea alba leaving a 1 cm space between the skin borders to cause secondary wound healing. This procedure provides a natural-looking umbilicus. It is easy and quick to do, and can be used for reconstruction after abdominoplasty, excision of a naevus, or when the umbilicus has been removed during a previous xiphopubic incision. 相似文献
168.
Omer Onur Cakir Fabio Castiglione Zafer Tandogdu Justin Collins Hussain M. Alnajjar Clare Akers Maarten Albersen Constantine Alifrangis Benjamin Ayres Oscar Brouwer Ivor Cullen Peter Hawkey Jakob Kristian Jakobsen Truls Erik Bjerklund Johansen Odunayo Kalejaiye Asheesh Kaul Bela Köves Vivekanandan Kumar Asif Muneer 《Urologic oncology》2021,39(3):197.e9-197.e17
ObjectivesTo develop an international consensus on managing penile cancer patients during the COVID-19 acute waves. A major concern for patients with penile cancer during the coronavirus disease 2019 (COVID-19) pandemic is how the enforced safety measures will affect their disease management. Delays in diagnosis and treatment initiation may have an impact on the extent of the primary lesion as well as the cancer-specific survival because of the development and progression of inguinal lymph node metastases.Materials and methodsA review of the COVID-19 literature was conducted in conjunction with analysis of current international guidelines on the management of penile cancer. Results were presented to an international panel of experts on penile cancer and infection control by a virtual accelerated Delphi process using 4 survey rounds. Consensus opinion was defined as an agreement of ≥80%, which was used to reconfigure management pathways for penile cancer.ResultsLimited evidence is available for delaying penile cancer management. The consensus rate of agreement was 100% that penile cancer pathways should be reconfigured, and measures should be developed to prevent perioperative nosocomial transmission of COVID-19. The panel also reached a consensus on several statements aimed at reconfiguring the management of penile cancer patients during the COVID-19 pandemic.ConclusionsThe international consensus panel proposed a framework for the diagnostic and invasive therapeutic procedures for penile cancer within a low-risk environment for COVID-19. 相似文献
169.
Minini Andrea Raes Matthias Taccone Fabio S. Malbrain Manu L. N. G. 《Journal of clinical monitoring and computing》2021,35(4):681-687
Journal of Clinical Monitoring and Computing - 相似文献
170.
Fabio Gaetano Santeramo Marco Tappi Emilia Lamonaca 《Health policy (Amsterdam, Netherlands)》2021,125(8):995-1001
The fast-moving coronavirus disease 2019 (COVID-19) called for a rapid response to slowing down the viral spread and reduce the fatality associated to the pandemic. Policymakers have implemented a wide range of non-pharmaceutical interventions to mitigate the spread of the pandemic and reduce burdens on healthcare systems. An efficient response of healthcare systems is crucial to handle a health crisis. Understanding how non-pharmaceutical interventions have contributed to slowing down contagions and how healthcare systems have impacted on fatality associated with health crisis is of utmost importance to learn from the COVID-19 pandemic. We investigated these dynamics in Italy at the regional level. We found that the simultaneous introduction of a variety of measures to increase social distance is associated with an important decrease in the number of new infected patients detected daily. Contagion reduces by 1% with the introduction of lockdowns in an increasing number of regions. We also found that a robust healthcare system is crucial for containing fatality associated with COVID-19. Also, proper diagnosis strategies are determinant to mitigate the severity of the health outcomes. The preparedness is the only way to successfully adopt efficient measures in response of unexpected emerging pandemics. 相似文献