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151.
Sandra E. Pike Lei Yao Karen D. Jones Barry Cherney Ettore Appella Kazuyasu Sakaguchi Hira Nakhasi Julie Teruya-Feldstein Peter Wirth Ghanshyam Gupta Giovanna Tosato 《The Journal of experimental medicine》1998,188(12):2349-2356
An endothelial cell inhibitor was purified from supernatant of an Epstein-Barr virus–immortalized cell line and identified as fragments of calreticulin. The purified recombinant NH2-terminal domain of calreticulin (amino acids 1–180) inhibited the proliferation of endothelial cells, but not cells of other lineages, and suppressed angiogenesis in vivo. We have named this NH2-terminal domain of calreticulin vasostatin. When inoculated into athymic mice, vasostatin significantly reduced growth of human Burkitt lymphoma and human colon carcinoma. Compared with other inhibitors of angiogenesis, vasostatin is a small, soluble, and stable molecule that is easy to produce and deliver. As an angiogenesis inhibitor that specifically targets proliferating endothelial cells, vasostatin has a unique potential for cancer treatment. 相似文献
152.
Ettore C. Degli Uberti Giorgio Trasforini Bruno Bagni Alberto Liboni Gian Carlo Pansini Giuseppe Altavilla 《International Journal of Clinical & Laboratory Research》1981,11(2):171-178
Summary This paper presents the results of the study of six patients with medullary thyroid carcinoma (MCT) and the epidemiological
screening carried out on the families of individuals affected by MCT. Three patients had the familial and three the sporadic
type of disease. In all the subjects the plasma calcitonin (CT) level was measured under basal conditions and after pentagastrin
stimulation. Patients with familial disease were also found to have pheochromocytoma (MEA syndrome). One patient, whose thyroid
was normal to palpation and radioisotope scanning and who did not have an elevated resting level of CT, showed a clearcut
CT elevation after provocative testing and subsequently was shown, by surgery, to have a small nodule of C-cell hyperplasia.
These results confirm that pentagastrin is a good stimulator of CT secretion and that i.v. administration of pentagastrin
is a useful test in the investigation of MCT in its early subclinical stage. 相似文献
153.
Bonelli MA Desenzani S Cavallini G Donati A Romani AA Bergamini E Borghetti AF 《Biogerontology》2008,9(1):1-10
Proteasome activity is known to decrease with aging in ad libitum (AL) fed rats. Severe caloric restriction (CR) significantly
extends the maximum life-span of rats, and counteracts the age-associated decrease in liver proteasome activities. Since few
investigations have explored whether lower CR diets might positively counteract the age associated decrease in proteasome
activity, we then investigated the effects of a mild CR regimen on animal life-span, proteasome content and function. In addition,
we addressed the question whether both CR regimens might also affect the expression of Hsc70 protein, a constitutive chaperone
reported to share a role in the function of proteasome complex and in the repair of proteotoxic damage, and whose level decreased
during aging. In contrast to severe CR, mild CR had a poor effect on life-span; however, it better counteracted the decrease
of proteasome activities. Both regimens, however, maintain Hsc70 in liver of old rats at level comparable to that of young
rats. Interestingly, the effects of aging and CRs on liver proteasome enzyme activities did not appear to be associated with
parallel changes in the amount of proteasome proteins suggesting that the quality (molecular activity of the enzymes) rather
than the quantity are likely to be modified with age. In conclusion, the results presented in this work show that a mild CR
can have beneficial effects on liver function of aging rats because is adequate to counteract the decrease of proteasome function
and Hsc70 chaperone level. 相似文献
154.
Distal embolization is a relatively common complication in primary angioplasty and is associated with poor perfusion and higher
mortality. The aim of this article is to critically review literature on thrombectomy devices to prevent distal embolization
in patients undergoing primary angioplasty. Several manual and mechanical devices have been proposed. Although negative data
have been observed with mechanical devices, significant impact on mortality has been observed with routine use of manual thrombectomy
devices, due to an improvement in myocardial perfusion and reduction in distal embolization. Therefore, routine adjunctive
manual thrombectomy devices should be recommended in the setting of ST-segment elevation myocardial infarction, whereas the
use of larger manual thrombectomy devices (7F) or mechanical devices may be considered in patients with large thrombotic burden
to provide more guarantees for complete thrombus removal. 相似文献
155.
Ettore Bartoli Pier Paolo Sainaghi Luca Bergamasco Luigi Castello 《Acta diabetologica》2010,47(2):147-154
Exact computations of glucose accumulation (GA, mM) and Na anions deficit (ΔNa, mEq) can be obtained in hypo-osmolar hyponatremic
hyperglycaemia (HHH), where plasma osmolality (POsm) is lower than normal. In this condition, GA − ΔNa = ∆POsm × TBW (total
body water). GA is given by plasma glucose concentration (PG1) times extra-cellular volume (ECV), calculated as TBW − ICV (the known intra-cellular volume). The changes in solute content
can then be computed from their concentrations. This model was verified on computer-simulated patients to whom GA was added
in variable amounts, lower than those of ΔNa subtracted, generating known ICV, ECV, PNa1, and PG1. True computer-generated values were identical (the correlation coefficient R
2 = 1, p < 0.0001) to those computed from solute concentrations with our formulas. These same calculations were applied to patients
with HHH, using exclusively the measured PNa1 and PG1 to compute solute and solvent changes. The results were significantly correlated to true data obtained by balance studies
(R
2 = 0.89, p < 0.001). The mathematical model correctly computes ΔNa and GA in HHH, where patients can therefore benefit from accurate
replacement strategies. 相似文献
156.
De Luca G Santagostino M Secco GG Cassetti E Giuliani L Coppo L Schaffer A Fundaliotis A Iorio S Venegoni L Bellomo G Marino P 《Journal of thrombosis and thrombolysis》2010,30(4):426-433
Even though platelet volume has been supposed to be indicator of platelet activation, contrasting results have been reported on its relationship with the extent of coronary artery disease (CAD). No data have been so far reported on Platelet-Large Cell Ratio (P-LCR). Thus, the aim of the current study was to investigate whether P-LCR is associated with CAD. We measured P-LCR in 1882 consecutive patients undergoing coronary angiography. Significant CAD was defined as stenosis >50% in at least 1 coronary vessel. We additionally measured Carotid Intima-Media Thickness (IMT) in 359 patients. The relationship between P-LCR and platelet aggregation was evaluated by PFA-100 and Multiplate. Patients with higher P-LCR were older (P = 0.038), with larger prevalence of diabetes (P < 0.0001), dilated cardiomyopathy or valvular heart disease (P = 0.004) and less often family history of CAD (P = 0.045), more often on statins (P = 0.002), and diuretics (P = 0.016). P-LCR was significantly associated with baseline glycaemia (P = 0.001) and RBC count (P < 0.001), but inversely related to platelet count (P < 0.0001). P-LCR was not associated with the prevalence of CAD (adjusted P = 0.3) or its severity. In addition, P-LCR was not related to Carotid IMT or platelet aggregation in patients with or without aspirin therapy. This study showed that P-LCR is not related to platelet aggregation, aspirin resistance, the extent of CAD and carotid IMT. Thus, P-LCR can not be considered as a marker of platelet reactivity or a risk factor for CAD. 相似文献
157.
158.
159.
Jacopo Marazzato Fabrizio Caravati Federico B. M. Blasi Taulant Refugjati Manola Vilotta Federica Torchio Andrea M. Musazzi Cesare Beghi Roberto De Ponti 《Clinical Case Reports》2021,9(8)
Late‐onset migration of pacing leads in the left hemithorax is a rare but potentially life‐threatening complication. Radiological examinations are required to detect any involvement of either left ventricle or lung parenchyma, prompting immediate surgical extraction in this setting. Identification of high‐risk patients is mandatory to prevent this complex iatrogenic complication. 相似文献
160.
Gustavsson A Svensson M Jacobi F Allgulander C Alonso J Beghi E Dodel R Ekman M Faravelli C Fratiglioni L Gannon B Jones DH Jennum P Jordanova A J?nsson L Karampampa K Knapp M Kobelt G Kurth T Lieb R Linde M Ljungcrantz C Maercker A Melin B Moscarelli M Musayev A Norwood F Preisig M Pugliatti M Rehm J Salvador-Carulla L Schlehofer B Simon R Steinhausen HC Stovner LJ Vallat JM Van den Bergh P den Bergh PV van Os J Vos P Xu W Wittchen HU J?nsson B Olesen J;CDBEStudy Group 《European neuropsychopharmacology》2011,21(10):718-779