全文获取类型
收费全文 | 1199篇 |
免费 | 110篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 55篇 |
妇产科学 | 24篇 |
基础医学 | 265篇 |
口腔科学 | 11篇 |
临床医学 | 117篇 |
内科学 | 284篇 |
皮肤病学 | 13篇 |
神经病学 | 141篇 |
特种医学 | 21篇 |
外科学 | 87篇 |
综合类 | 5篇 |
预防医学 | 110篇 |
眼科学 | 5篇 |
药学 | 97篇 |
中国医学 | 1篇 |
肿瘤学 | 67篇 |
出版年
2023年 | 15篇 |
2022年 | 24篇 |
2021年 | 43篇 |
2020年 | 22篇 |
2019年 | 42篇 |
2018年 | 42篇 |
2017年 | 29篇 |
2016年 | 39篇 |
2015年 | 46篇 |
2014年 | 50篇 |
2013年 | 60篇 |
2012年 | 119篇 |
2011年 | 112篇 |
2010年 | 50篇 |
2009年 | 33篇 |
2008年 | 69篇 |
2007年 | 79篇 |
2006年 | 82篇 |
2005年 | 57篇 |
2004年 | 67篇 |
2003年 | 58篇 |
2002年 | 49篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 6篇 |
1998年 | 10篇 |
1997年 | 7篇 |
1996年 | 10篇 |
1995年 | 7篇 |
1994年 | 9篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 6篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1962年 | 1篇 |
1961年 | 1篇 |
1960年 | 2篇 |
1959年 | 2篇 |
1955年 | 2篇 |
1938年 | 2篇 |
1927年 | 1篇 |
排序方式: 共有1317条查询结果,搜索用时 15 毫秒
81.
Simohamed Belmouaz Estelle Desport Fannie Leroy Julie Teynie Jér?me Hannequin Ramzi Abou Ayache Frank Bridoux Guy Touchard 《Nephrology, dialysis, transplantation》2008,23(1):417-419
Sir, Intravenous immunoglobulin (IvIg) is commonly used in nephrologyunits for the treatment of auto-immune diseases, antibody-mediatedrenal allograft rejection and immune deficiencies. Minor adverseeffects, such as myalgia, headache, shiver, nausea, vomitingor fever occur in <20% of patients. Major reactions includingrenal failure, thromboembolism, aseptic meningitis and anaphylaxisare less common. Whereas osmotic nephropathy resulting frommaltose and saccharose toxicity is well-known to nephrologists,posterior reversible encephalopathy syndrome (PRES) is a rareand potentially severe adverse event of IvIg therapy. A 42-year-old man was admitted 相似文献
82.
Estelle Jean Dit Gautier Julien Lepage Mathias Brieu Michel Cosson Chrystele Rubod 《International urogynecology journal》2018,29(3):425-430
Introduction and hypothesis
We studied the geometry of and changes in structures that play an important role in stabilizing the pelvic system during pregnancy using a numerical system at different gestational ages and postpartum.Methods
We developed a parturient numerical model to assess pelvic structures at different gestational stages (16, 32, and 38 weeks) and postpartum (2 months and 1 year) using magnetic resonance imaging (MRI). Organs, muscles, and ligaments were segmented to generate a 3D model of the pelvis. We studied changes in the length of uterosacral ligaments (USL) and thickness of the puborectal portion of the levator ani muscle (LAM) during and after pregnancy. We used this model to perform finite element (FE) simulation and analyze deformations of these structures under stress from the increase in uterine weight.Results
Analysis reveals an increase in the length of US ligaments at 16, 32, and 38 weeks. Two months after delivery, it decreases without returning to the length at 16 weeks of pregnancy. Similar changes were observed for the puborectal portion of the LAM. Variations observed in these structures are not equivalent to other anatomical structures of pelvic suspension. FE simulation with increased uterus weight does not lead to those findings.Conclusion
This analysis brings new elements and a new focus for discussion relating to changes in pelvic balance of parturient women that are not simply linked to the increase in uterine volume.83.
RMi Targhetta Jean-Marie Bourgeois Roseline Chavagneux Estelle Coste Dominique Amy Pierre Balmes Landre Pourcelot 《Journal of clinical ultrasound : JCU》1993,21(4):245-250
Ultrasonography is considered to have limited application in respiratory diseases because air reflects sound waves. Twenty-four patients with radiologically confirmed pneumothorax and 100 healthy subjects underwent sonography. In all normal subjects, the hyperechoic pulmonary interface showed respiratory motions termed the “gliding sign” with some comet-tail artifacts. Sonographic signs were shown in all pneumothoraces: disappearance of the gliding sign and no comet tails. The extent of collapse cannot be evaluated, but it is possible to determine its area in partial pneumothorax (N = 5). The follow-up (N = 8) showed the reappearance of the gliding sign. Ultrasonography may be helpful in diagnosing pneumothorax in certain cases. © 1993 John Wiley & Sons, Inc. 相似文献
84.
85.
Jennifer Franois Estelle Koning Arielle Ferrandon Guy Sandner Astrid Nehlig 《Hippocampus》2010,20(7):841-851
Longitudinal studies on patients for schizophrenia suggest that functional brain perturbations precede the onset of symptoms. Rats with a neonatal ventral hippocampal lesion (NVHL) are considered as a heuristic neurodevelopmental model of schizophrenia. We characterized basal metabolic changes observed in NVHL rats before and after the age when known behavioral alterations have been reported. Male pups were lesioned with ibotenic acid at postnatal day 7 (PD7). We measured local cerebral metabolic rates for glucose (LCMRglc) by the quantitative autoradiographic [14C]2‐deoxyglucose technique at pre‐ (PD21) and postpubertal (PD42) ages when NVHL rats do not express abnormal dopamine related behaviors, and at adulthood (PD70). We observed a widespread increase in LCMRglcs in PD21 NVHL indicative of an ongoing intense reorganization of the brain while at PD42, increases were less extended. At PD70, changes in glucose metabolism were restricted to specific systems, such as the auditory system, the cerebellum, the serotonergic median raphe, and median septum. These data show in a heuristic animal model of schizophrenia that functional metabolic changes within the brain could precede the onset of dopamine‐related behavioral alterations and lead to a distinct ensemble of functional changes in adulthood in systems that may be relevant to schizophrenia. © 2009 Wiley‐Liss, Inc. 相似文献
86.
Morand PC Burgel PR Carlotti A Desmazes-Dufeu N Farhi D Martin C Kanaan R Mangialavori L Palangié E Dusser D Poyart C Hubert D 《Journal of clinical microbiology》2011,49(2):750-751
Tuberculosis (TB) is rarely observed in cystic fibrosis (CF) patients. We report the first case of mediastinal TB, associated with leg pain and skin rash, in an adult patient with CF, and discuss factors suggestive of TB in the course of CF. 相似文献
87.
Mathew A Cao H Collin E Wang W Pandit A 《International journal of pharmaceutics》2012,434(1-2):99-105
A unique hyperbranched polymeric system with a linear poly-2-dimethylaminoethyl methacrylate (pDMAEMA) block and a hyperbranched polyethylene glycol methyl ether methacrylate (PEGMEMA) and ethylene dimethacrylate (EGDMA) block was designed and synthesized via deactivation enhanced atom transfer radical polymerisation (DE-ATRP) for efficient gene delivery. Using this unique structure, with a linear pDMAEMA block, which efficiently binds to plasmid DNA (pDNA) and hyperbranched polyethylene glycol (PEG) based block as a protective shell, we were able to maintain high transfection levels without sacrificing cellular viability even at high doses. The transfection capability and cytotoxicity of the polymers over a range of pDNA concentration were analysed and the results were compared to commercially available transfection vectors such as polyethylene imine (branched PEI, 25 kDa), partially degraded poly(amido amine)dendrimer (dPAMAM; commercial name: SuperFect(?)) in fibroblasts and adipose tissue derived stem cells (ADSCs). 相似文献
88.
Behavioral studies have used visuo-tactile conflicts between a participant's body and a visually presented fake or virtual body to investigate the importance of bodily perception for self-consciousness (bodily self-consciousness). Illusory self-identification with a fake body and changes in tactile processing--modulation of visuo-tactile cross-modal congruency effects (CCEs)--were reported in previous findings. Although proprioceptive signals are deemed important for bodily self-consciousness, their contribution to the representation of the full body has not been studied. Here we investigated whether and how self-identification and tactile processing (CCE magnitude) could be modified by altering proprioceptive signals with 80-Hz vibrations at the legs. Participants made elevation judgments of tactile cues (while ignoring nearby lights) during synchronous and asynchronous stroking of a seen fake body. We found that proprioceptive signals during vibrations altered the magnitude of self-identification and mislocalization of touch (CCE) in a synchrony-dependent fashion: we observed an increase of self-identification and CCE magnitude during asynchronous stroking. In a second control experiment we studied whether proprioceptive signals per se, or those from the lower limbs in particular, were essential for these changes. We applied vibrations at the upper limbs (which provide no information about the position of the participant's body in space) and in this case observed no modulation of bodily self-consciousness or tactile perception. These data link proprioceptive signals from the legs that are conveyed through the dorsal column-medial lemniscal pathway to bodily self-consciousness. We discuss their integration with bodily signals from vision and touch for full-body representations. 相似文献
89.
90.
Soumaya Mougou-Zerelli Sophie Thomas Emmanuelle Szenker Sophie Audollent Nadia Elkhartoufi Candice Babarit Stéphane Romano Rémi Salomon Jeanne Amiel Chantal Esculpavit Marie Gonzales Estelle Escudier Bruno Leheup Philippe Loget Sylvie Odent Jo?lle Roume Marion Gérard Anne-Lise Delezoide Suonavy Khung Sophie Patrier Marie-Pierre Cordier Raymonde Bouvier Jéléna Martinovic Marie-Claire Gubler Nathalie Boddaert Arnold Munnich Férechté Encha-Razavi Enza Maria Valente Ali Saad Sophie Saunier Michel Vekemans Tania Attié-Bitach 《Human mutation》2009,30(11):1574-1582
Meckel-Gruber syndrome (MKS) is a lethal fetal disorder characterized by diffuse renal cystic dysplasia, polydactyly, a brain malformation that is usually occipital encephalocele, and/or vermian agenesis, with intrahepatic biliary duct proliferation. Joubert syndrome (JBS) is a viable neurological disorder with a characteristic “molar tooth sign” (MTS) on axial images reflecting cerebellar vermian hypoplasia/dysplasia. Both conditions are classified as ciliopathies with an autosomal recessive mode of inheritance. Allelism of MKS and JBS has been reported for TMEM67/MKS3, CEP290/MKS4, and RPGRIP1L/MKS5. Recently, one homozygous splice mutation with a founder effect was reported in the CC2D2A gene in Finnish fetuses with MKS, defining the 6th locus for MKS. Shortly thereafter, CC2D2A mutations were also reported in JBS. The analysis of the CC2D2A gene in our series of MKS fetuses, identified 14 novel truncating mutations in 11 cases. These results confirm the involvement of CC2D2A in MKS and reveal a major contribution of CC2D2A to the disease. We also identified three missense CC2D2A mutations in two JBS cases. Therefore, and in accordance with the data reported regarding RPGRIP1L, our results indicate phenotype–genotype correlations, as missense and presumably hypomorphic mutations lead to JBS while all null alleles lead to MKS. Hum Mutat 30:1–9, 2009. © 2009 Wiley-Liss, Inc. 相似文献