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Eriko Takatori Tadahiro Shoji Yasuko Suga Hanae Niinuma Yuki Miura Yoshitaka Kaido Anna Takada Masahiro Kagabu Satoshi Takeuchi Toru Sugiyama 《International journal of clinical oncology / Japan Society of Clinical Oncology》2014,19(2):336-340
Background
The efficacy and safety of S-1/oxaliplatin (SOX) therapy in patients with recurrent adenocarcinoma of the uterine cervix were examined in a pilot study.Patients and methods
S-1 was orally administered for 14 days at a dose of 80–120 mg/body/day to 7 patients with recurrent adenocarcinoma of the uterine cervix, with oxaliplatin being administered intravenously at a dose of 100 mg/m2 on day 1. Each therapy cycle was 21 days, and the patients received 6 cycles at most. The antitumor effect, adverse events, progression-free survival (PFS), and overall survival (OS) were investigated.Results
The median age of the patients was 49 years. The antitumor effect was rated as a complete response in 2 patients, partial response in 2, and stable disease in 3. The overall response rate was 57.1 %, and the disease control rate was 100 %. Regarding hematological toxicities of grade 3 or more, leukopenia, neutropenia and thrombocytopenia occurred in 42.9, 28.6 and 14.3 %, respectively; regarding non-hematological toxicities, grade 3 rectovaginal fistula occurred in 14.3 %, as well as grade 2 fatigue in 14.3 % of the patients. The median PFS and OS were 5 months (range 3–9 months) and 7 months (range 4–43 months), respectively.Conclusions
These results suggest that SOX therapy is useful for the treatment of recurrent adenocarcinoma of the uterine cervix, having a promising antitumor effect and minimal adverse effects. It was also suggested that SOX therapy may contribute to improving the prognosis for patients with adenocarcinoma of the uterine cervix. 相似文献994.
Akemi Kataoka Eriko Tokunaga Norikazu Masuda Tadahiko Shien Kimiko Kawabata Mika Miyashita 《Breast cancer (Tokyo, Japan)》2014,21(6):643-650
Background
To clarify the clinicopathological features of breast cancer in young females, surveillance data of the Registration Committee of the Japanese Breast Cancer Society were analyzed.Methods
The clinicopathological characteristics were compared between young (<35) patients and non-young (≥35) patients among 109,617 records registered between 2004 and 2009.Results
The numbers of young and non-young patients were 2,982 (2.7 %) and 106,295 (97.0 %), respectively. The young patients had more cases of a familial history of breast cancer, more subjective symptoms, fewer bilateral tumors, lower BMIs, larger tumors, more positive lymph nodes, fewer instances of an ER-positive status, more instances of an HER2-positive status, more triple-negative tumors and more advanced TNM stages. The young patients more frequently received neoadjuvant chemotherapy and breast-conserving therapy (BCT) compared with the non-young patients. Eighty percent of all patients received adjuvant therapy. The young patients were more frequently treated with chemotherapy, molecular targeted therapy and radiation therapy than the non-young patients.Conclusions
In this study, young patients with breast cancer were diagnosed at more advanced stages and had more endocrine-unresponsive tumors than non-young patients. Further prognostic analyses should be conducted in this cohort. 相似文献995.
Keely M. McNamara Tomomi Yoda Alif Meem Nurani Yukiko Shibahara Yasuhiro Miki Lin Wang Yasuhiro Nakamura Koyu Suzuki Yang Yang Eriko Abe Hisashi Hirakawa Takashi Suzuki Noriko Nemoto Minoru Miyashita Kentaro Tamaki Takanori Ishida Kristy A. Brown Noriaki Ohuchi Hironobu Sasano 《Breast cancer research and treatment》2014,145(2):281-293
One of the active intracellular pathways/networks in triple-negative breast carcinoma (TNBC) is that of the androgen receptor (AR). In this study, we examined AR and androgen-metabolising enzyme immunoreactivity in subcategories of TNBC to further elucidate the roles of androgenic pathways in TNBC. We utilised formalin-fixed paraffin-embedded breast cancer samples from ductal carcinoma in situ (DCIS) and invasive ductal carcinoma patient cohorts. We then used immunohistochemistry to classify these samples into basal-like and non-basal samples and to assess interactions between AR, androgen-metabolising enzymes and proliferation. To further substantiate our hypothesis and provide mechanistic insights, we also looked at the expression and regulation of these factors in publically available microarray data and in a panel of TNBC AR-positive cell lines. DCIS was associated with higher levels of AR and enzymes (p < 0.02), although a similar difference was not noticed in basal and non-basal samples. AR and enzymes were correlated in all states. In TNBC cell lines (MDA-MD-453, MFM-223 and SUM185-PE), we found that DHT treatment up-regulated 5αR1 and 17βHSD5 suggesting a mechanistic explanation for the correlations observed in the histological samples. Publicly available microarray data in TNBC cases suggested similar patterns to those observed in histological samples. In the majority of settings, including publically available microarray data, an inverse association between AR and proliferation was detected. These findings suggest that decreases in AR and androgen-metabolising enzymes may be involved in the increased biological aggressiveness in TNBC development. 相似文献
996.
Isago H Sugano E Wang Z Murayama N Koyanagi E Tamai M Tomita H 《Journal of molecular neuroscience : MN》2012,46(2):393-400
The objective of this study is to investigate age-related differences in recovered visual function in Royal College of Surgeons
(RCS) rats transduced with the Channelrhodopsin-2 (ChR2) gene. An adeno-associated virus vector that contained ChR2 was injected intravitreously into young or aged RCS rats. After 4 months, visual evoked potentials were recorded. To estimate
the transduction efficiencies, ChR2V-expressing cells and retrograde labeled retinal ganglion cells (RGCs) were counted. After
photoreceptor degradation, immunohistochemistry was used to detect glial fibrillary acidic protein (GFAP) in the retinas.
The amplitudes and latencies from young RCS rats were higher and shorter, respectively, than those from aged RCS rats. ChR2V
was expressed in the RGCs of both groups of rats; there was no significant difference in the transduction efficiency of either
group. However, the number of RGCs in aged RCS rats was significantly less than that in young RCS rats. In addition, strong
GFAP immunoreactivity was observed after photoreceptor degeneration, whereas it was weaker in ChR2V-expressing RGCs. ChR2 transduction produced photosensitive RGCs in both young and aged rats. However, the degree of recovery depended on the age
at the time of transduction. 相似文献
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999.
Goreshi R Okawa J Rose M Feng R Lee LA Hansen CB Bangert CA Connolly MK Davis MD Callen JP Fett NM Fakharzadeh SS Clarke JT Werth VP 《The Journal of investigative dermatology》2012,132(4):1117-1124
To properly evaluate therapies for cutaneous dermatomyositis (DM), it is essential to administer an outcome instrument that is reliable, valid, and responsive to clinical change, particularly when measuring disease activity. The purpose of this study was to compare two skin severity DM outcome measures, the Cutaneous Disease and Activity Severity Index (CDASI) and the Cutaneous Assessment Tool-Binary Method (CAT-BM), with the Physician Global Assessment (PGA) as the "gold standard". Ten dermatologists evaluated 14 patients with DM using the CDASI, CAT-BM, and PGA scales. Inter- and intra-rater reliability, validity, responsiveness, and completion time were compared for each outcome instrument. Responsiveness was assessed from a different study population, where one physician evaluated 35 patients with 110 visits. The CDASI was found to have a higher inter- and intra-rater reliability. Regarding construct validity, both the CDASI and the CAT-BM were significant predictors of the PGA scales. The CDASI had the best responsiveness among the three outcome instruments examined. The CDASI had a statistically longer completion time than the CAT-BM by about 1.5?minutes. The small patient population may limit the external validity of the findings observed. The CDASI is a better clinical tool to assess skin severity in DM. 相似文献
1000.
Ogawa B Wang L Ohishi T Taniai E Akane H Suzuki K Mitsumori K Shibutani M 《Archives of toxicology》2012,86(5):779-790
We have recently shown that maternal exposure to acrylamide (AA) impaired neurogenesis in rat offspring measured by the increase
in interneurons producing reelin, a molecule regulating migration and correct positioning of developing neurons, in the hippocampal
dentate gyrus. To clarify the cellular target of AA on hippocampal neurogenesis and its reversibility after maternal exposure,
pregnant Sprague–Dawley rats were given drinking water containing AA at 0, 4, 20, 100 ppm on day 10 of pregnancy through day
21 after delivery on weaning. Male offspring were examined immunohistochemically on postnatal day (PND) 21 and PND 77. For
comparison, male pups of direct AA-injection control during lactation (50 mg/kg body weight, intraperitoneally, 3 times/week)
were also examined. On PND 21, maternal AA-exposure decreased progenitor cell proliferation in the subgranular zone (SGZ)
from 20 ppm accompanied with increased density of reelin-producing interneurons and NeuN-expressing mature neurons within
the hilus at 100 ppm, similar to the direct AA-injection control. In the SGZ examined at 100 ppm, cellular populations immunoexpressing
doublecortin or dihydropyrimidinase-like 3, suggesting postmitotic immature granule cells, were decreased. On PND 77, the
SGZ cell proliferation and reelin-producing interneuron density recovered, while the hilar mature neurons sustained to increase
from 20 ppm, similar to the direct AA-injection control. Thus, developmental exposure to AA reversibly affects hippocampal
neurogenesis targeting the proliferation of type-3 progenitor cells resulting in a decrease in immature granule cells in rats.
A sustained increase in hilar mature neurons could be the signature of the developmental effect of AA. 相似文献