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101.
María Dolores Arenas Jiménez Mónica Navarro García Encarnación Serrano Reina Fernando Álvarez-Ude 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2019,39(5):531-538
IntroductionInstrumental Activities of Daily Life (IADL) requires a higher level of personal autonomy and interaction with the environment than the basic activities of daily life (BADL). Few studies analyze the deficit on IADL. Early detection is important because an early action can delay the evolution of the dependency process.Aimto know the prevalence of functional deficit in IADL of hemodialysis patients, its relationship with the functional deficit in the BADL and its influence on the health related quality of life (HRQoL).MethodsCross-sectional study in 66 patients on HD. Different scales were used: Lawton and Brody (AIVD dependency), Delta (BADL dependency), and COOP-WONCA (HRQOL). Clinical data were collected (age, sex, CKD etiology, months in HD, marital status, employment situation).Results80.3% of the patients had some degree of dependence for the IADL (57.5% in moderate/severe degree) and 40.8% for the BADL (9% in moderate/severe degree). There was a correlation between dependence to the BADL and AIVD. Age and employment status influence the dependence on IADL and BADL. Patients with greater dependence on IADL had worse HRQoL (P < .000). The dimensions in which they showed greater differences were “Daily activities”, “Social activities” and “Social support”.ConclusionsHD patients are more dependent on IADL than on ADL and with a higher degree of severity and the level of dependence in both types of activities has important influence on HRQoL. Early detection of the occurrence of disability in the realization of IADL can be used to initiate intervention programs that help to prevent, reverse or delay the progression. 相似文献
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Picornavirus RNA translation is driven by the internal ribosome entry site (IRES) element. The impact of RNA structure on the foot-and-mouth disease virus (FMDV) IRES activity has been analyzed using Selective 2'Hydroxyl Acylation analyzed by Primer Extension (SHAPE) and high throughput analysis of RNA conformation by antisense oligonucleotides printed on microarrays. SHAPE reactivity revealed the self-folding capacity of domain 3 and evidenced a change of RNA structure in a defective GNRA mutant. A modified RNA conformation of this mutant was also evidenced by RNA accessibility to oligonucleotides. Interestingly, comparison of nucleotide reactivity with RNA accessibility revealed that SHAPE reactive nucleotides corresponding to the GNRA motif were not accessible to their respective target oligonucleotides. The differential response was observed both in domain 3 and the entire IRES. Our results demonstrate distant effects of the GNRA motif in the domain 3 RNA conformation, and highlight the modular organization of a picornavirus IRES. 相似文献
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Carmen Guillén-Ponce Adela Castillejo Víctor M. Barberá J. Carlos Pascual-Ramírez Encarnación Andrada M. Isabel Castillejo Carla Guarinós M. J. Molina-Garrido Alfredo Carrato J. L. Soto 《Familial cancer》2010,9(2):151-154
Muir-Torre syndrome is a rare, inherited disease predisposing of gastrointestinal and cutaneous tumours, such as keratoacanthomas
and sebaceous gland adenomas. Muir-Torre syndrome is usually inherited in an autosomal dominant fashion and associated with
mutations in the mismatch repair genes, predominantly in MLH1 and MSH2 genes. This report describes a man who has multiple
adenomatous colon polyps, a gastric cancer, multiple colorectal cancers and sebaceous adenomas caused by biallelic MYH germline mutations. This finding demonstrates that MYH gene analysis should be considered in Muir-Torre families where no mismatch repair gene mutations have been found. Furthermore,
this report contributes to characterize the clinical phenotype caused by biallelic mutations in MYH gene, which may share with other hereditary colon cancer syndromes. 相似文献
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Carlos Campos Rodrigo Guzmán Encarnación López-Fernández Ángela Casado 《Clinical biochemistry》2010,43(3):228-233
ObjectivesTo evaluate the urinary levels of uric acid (UA) and total antioxidant capacity (TAC) with and without UA relative contribution (TAC?UA) in children and adults with Down syndrome (DS) and to prove the clinical use of TAC.Design and methodsUrine samples were obtained from 32 individuals with DS and 29 controls. Two age groups were established (children and adults). Spectrophotometric methods were used for biochemical determinations.ResultsChildren with DS had significantly higher UA/Cr and TAC/Cr levels than controls, whereas levels of TAC?UA/Cr were lower in adults with DS than in controls (P < 0.05 for all). In DS, levels of UA/Cr, TAC/Cr and TAC?UA/Cr were higher in children than in adults (P < 0.05 for all). Positive correlations between UA/Cr and TAC/Cr were found for all groups studied. Negative correlations with age were found for UA/Cr and TAC/Cr in children of both groups.ConclusionsOur results proved that TAC is decreased in adults with DS. Besides, TAC?UA seems to provide more reliable information about the antioxidant status, at least in DS. 相似文献
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Quinazolinones,Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation 下载免费PDF全文
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Nuria?Tormo Eliseo?Albert Emilio?Borrajo Monserrat?Bosque Juan?José?Camarena Victoria?Domínguez Encarnación?Fuentes Isabel?Gascón Bárbara?Gomila Nieves?Gonzalo Marta?Jiménez Olalla?Martínez José?Miguel?Nogueira Nieves?Orta Josep?Prat Juan?Carlos?Rodríguez Concepción?Gimeno David?Navarro 《European journal of clinical microbiology & infectious diseases》2018,37(11):2069-2074
A questionnaire-based cross-sectional study was conducted to gather information on current microbiological practices for active surveillance of carriage of multidrug-resistant (MDR) bacteria in hospitals from 14 health departments of the Autonomous Community of Valencia (ACV), Spain, which together provided medical attention to 3,271,077 inhabitants in 2017, approximately 70% of the population of the ACV. The survey consisted of 35 questions on MDR bacteria screening policies, surveillance approach chosen (universal vs. targeted), and microbiological methods and processes in use for routine detection and reporting of colonization by MDR bacteria, including the anatomical sites scheduled to be sampled for each MDR bacterial species, and the methodology employed (culture-based, molecular-based, or both). Our study revealed striking differences across centers, likely attributable to the lack of consensus on optimal protocols for sampling, body sites for screening, and microbiological testing, thus underscoring the need for consensus guidelines on these issues. 相似文献