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31.
Sucha Nand MD Leo I. Gordon MD Elmer Brestan MD Charlotte Harris MD Thomas Brandt MD 《Cancer》1982,50(9):1882-1883
Tamoxifen is a useful agent in the management of metastatic breast cancer. We describe a patient who was treated sucessfully with Tamoxifen but developed a benign but symptomatic hepatic cyst during treatment. Development of a solitary hepatic lesion during Tamoxifen therapy should be thoroughly investigated before treatment is changed. Cancer 50:1882-1883, 1982. 相似文献
32.
This article focuses on the experience of victimization among a representative sample of 141 homeless women interviewed in a single-adult shelter in New York City. The frequency of victimization experiences, specifically aggressive sexual and physical assault, was high. Twenty-one women reported being raped, 42 women reported both rape and physical abuse, and 62 women reported physical abuse without sexual abuse. Shelter women reporting frequent experiences were likely to experience high levels of depressive symptoms; psychotic symptoms; and hospitalization for psychiatric, medical, alcohol, and drug problems. These results further indicate that assault experiences cluster in specific ways and are associated with different clinical outcomes. These findings are seen as underscoring the need for service delivery programs to respond to the experience of vicitimization among homeless women and suggest some future research directions. 相似文献
33.
Gabriela A. Merino Yanina A. Murua Cristóbal Fresno Juan M. Sendoya Mariano Golubicki Soledad Iseas Mariana Coraglio Osvaldo L. Podhajcer Andrea S. Llera Elmer A. Fernández 《Human mutation》2017,38(5):494-502
Targeted sequencing (TS) is growing as a screening methodology used in research and medical genetics to identify genomic alterations causing human diseases. In general, a list of possible genomic variants is derived from mapped reads through a variant calling step. This processing step is usually based on variant coverage, although it may be affected by several factors. Therefore, undercovered relevant clinical variants may not be reported, affecting pathology diagnosis or treatment. Thus, a prior quality control of the experiment is critical to determine variant detection accuracy and to avoid erroneous medical conclusions. There are several quality control tools, but they are focused on issues related to whole‐genome sequencing. However, in TS, quality control should assess experiment, gene, and genomic region performances based on achieved coverages. Here, we propose TarSeqQC R package for quality control in TS experiments. The tool is freely available at Bioconductor repository. TarSeqQC was used to analyze two datasets; low‐performance primer pools and features were detected, enhancing the quality of experiment results. Read count profiles were also explored, showing TarSeqQC's effectiveness as an exploration tool. Our proposal may be a valuable bioinformatic tool for routinely TS experiments in both research and medical genetics. 相似文献
34.
35.
EK Kim GJ Gerling SM Bourdon SA Wellnitz EA Lumpkin 《Journal of neuroengineering and rehabilitation》2012,9(1):45
ABSTRACT: BACKGROUND: The next generation of prosthetic limbs will restore sensory feedback to the nervous system by mimicking how skin mechanoreceptors, innervated by afferents, produce trains of action potentials in response to compressive stimuli. Prior work has addressed building sensors within skin substitutes for robotics, modeling skin mechanics and neural dynamics of mechanotransduction, and predicting response timing of action potentials for vibration. The effort here is unique because it accounts for skin elasticity by measuring force within simulated skin, utilizes few free model parameters for parsimony, and separates parameter fitting and model validation. Additionally, the ramp-and-hold, sustained stimuli used in this work capture the essential features of the everyday task of contacting and holding an object. METHODS: This systems integration effort computationally replicates the neural firing behavior for a slowly adapting type I (SAI) afferent in its temporally varying response to both intensity and rate of indentation force by combining a physical force sensor, housed in a skin-like substrate, with a mathematical model of neuronal spiking, the leaky integrate-and-fire. Comparison experiments were then conducted using ramp-and-hold stimuli on both the spiking-sensor model and mouse SAI afferents. The model parameters were iteratively fit against recorded SAI interspike intervals (ISI) before validating the model to assess its performance. RESULTS: Model-predicted spike firing compares favorably with that observed for single SAI afferents. As indentation magnitude increases (1.2, 1.3, to 1.4 mm), mean ISI decreases from 98.81 +/- 24.73, 54.52 +/- 6.94, to 41.11 +/- 6.11 ms. Moreover, as rate of ramp-up increases, ISI during ramp-up decreases from 21.85 +/- 5.33, 19.98 +/- 3.10, to 15.42 +/- 2.41 ms. Considering first spikes, the predicted latencies exhibited a decreasing trend as stimulus rate increased, as is observed in afferent recordings. Finally, the SAI afferent's characteristic response of producing irregular ISIs is shown to be controllable via manipulating the output filtering from the sensor or adding stochastic noise. CONCLUSIONS: This integrated engineering approach extends prior works focused upon neural dynamics and vibration. Future efforts will perfect measures of performance, such as first spike latency and irregular ISIs, and link the generation of characteristic features within trains of action potentials with current pulse waveforms that stimulate single action potentials at the peripheral afferent. 相似文献
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38.
The DASH diet and blood pressure 总被引:2,自引:0,他引:2
Craddick SR Elmer PJ Obarzanek E Vollmer WM Svetkey LP Swain MC 《Current atherosclerosis reports》2003,5(6):484-491
High blood pressure (also called hypertension) is one of the most important and common risk factors for atherosclerotic cardiovascular
disease (CVD) and other chronic diseases. National guidelines recommend that all individuals with blood pressure readings
of 120/80 mm Hg or higher adopt healthy lifestyle habits, including the Dietary Approaches to Stop Hypertension (DASH) diet,
to manage their blood pressure. The DASH diet, which is high in fruits, vegetables, and low-fat dairy products and reduced
in fat, has been shown in large, randomized, controlled trials to reduce blood pressure significantly. The DASH diet also
has been shown to reduce blood cholesterol and homocysteine levels and to enhance the benefits of antihypertensive drug therapy.
The DASH diet should be promoted, along with maintaining healthy weight, reducing sodium intake, increasing regular physical
activity, and limiting alcohol intake, for lowering blood pressure and reducing the risk of CVD. 相似文献
39.
Congenital triangular alopecia is a nonscarring loss of hair mass on the scalp's temporal regions. The area of hair diminution commonly is described as triangular or lancet shaped. Although previously considered congenital, this condition usually is noticed after 2 years of age and, more recently, is thought to be acquired. We propose that this entity be renamed triangular alopecia. Because this condition involves normal rather than inflamed skin, it does not respond to topical or intralesional steroids. It is important to make the correct diagnosis to avoid unnecessary and potentially harmful interventions. We present the case of a 10-year-old boy with triangular alopecia. 相似文献
40.
Elmer R. Freeman Doug Brugge Willie Mae Bennett-Bradley Jonathan I. Levy Edna Rivera Carrasco 《Journal of urban health》2006,83(6):1013-1021
Boston is one of the preeminent health care and research centers in the world, but for much of its urban core, these resources
are largely out of reach. Community Based Participatory Research (CBPR) provides a model with the potential to bridge the
gaps between its research prominence and the health of its residents. We report here two case studies of major research projects
that were partnerships between universities in Boston and community based organizations and city agencies. The Healthy Public
Housing Initiative (HPHI) and the Asthma Center on Community Environment and Social Stress (ACCESS) are projects that provide
numerous lessons about the potential and challenges of conducting CBPR. Ensuring that the projects were true partnerships
emerged as key issues in both, especially with respect to funding mechanisms and distribution of resources, although the nature
of the challenges differed substantially in the two projects. We note that both academic and community partners may harbor
stereotypes about the other and that generalizations about broad populations, academics or community members, may not apply
well to everyone. Aligning objectives and expectations emerged as another key lesson. In HPHI, tension between service delivery
and research was both a source of conflict and a source of creative development that led to divergent but interesting outcomes.
In ACCESS, the tensions revolved more around community capacity building while attempting to build and maintain a large cohort
for epidemiological investigations. We conclude that open and frank discussion and a transparent process upfront about project
direction, finances, expectations, and other dimensions are necessary but not sufficient to address the inherent challenges
in CBPR, and that even so, there are likely to be differences in perspective in such partnerships that require honest negotiation
throughout the process of the project. 相似文献