全文获取类型
收费全文 | 1601篇 |
免费 | 78篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 31篇 |
妇产科学 | 34篇 |
基础医学 | 213篇 |
口腔科学 | 6篇 |
临床医学 | 121篇 |
内科学 | 398篇 |
皮肤病学 | 18篇 |
神经病学 | 115篇 |
特种医学 | 167篇 |
外科学 | 234篇 |
综合类 | 25篇 |
预防医学 | 55篇 |
眼科学 | 26篇 |
药学 | 58篇 |
中国医学 | 5篇 |
肿瘤学 | 160篇 |
出版年
2024年 | 2篇 |
2023年 | 11篇 |
2022年 | 23篇 |
2021年 | 55篇 |
2020年 | 31篇 |
2019年 | 42篇 |
2018年 | 52篇 |
2017年 | 38篇 |
2016年 | 53篇 |
2015年 | 41篇 |
2014年 | 47篇 |
2013年 | 67篇 |
2012年 | 100篇 |
2011年 | 101篇 |
2010年 | 56篇 |
2009年 | 54篇 |
2008年 | 87篇 |
2007年 | 99篇 |
2006年 | 77篇 |
2005年 | 68篇 |
2004年 | 100篇 |
2003年 | 72篇 |
2002年 | 88篇 |
2001年 | 26篇 |
2000年 | 33篇 |
1999年 | 32篇 |
1998年 | 15篇 |
1997年 | 12篇 |
1996年 | 11篇 |
1995年 | 12篇 |
1994年 | 13篇 |
1993年 | 13篇 |
1992年 | 18篇 |
1991年 | 18篇 |
1990年 | 15篇 |
1989年 | 9篇 |
1988年 | 12篇 |
1987年 | 6篇 |
1986年 | 12篇 |
1985年 | 19篇 |
1984年 | 12篇 |
1983年 | 8篇 |
1981年 | 3篇 |
1980年 | 7篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1974年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有1683条查询结果,搜索用时 93 毫秒
21.
22.
Kouji Kawai Tetsuya Sakairi Shuichi Harada Junko Shinozuka Mika Ide Hiroko Sato Masaharu Tanaka Wataru Toriumi Eisuke Kume 《Experimental and toxicologic pathology》2012,64(4):333-338
SHR/NDmcr-cp (SHR/NDcp) rats, which carry a nonsense mutation of the leptin receptor gene, are known to spontaneously develop hypertension, obesity and hyperlipidemia, and have therefore found use as an animal model of the metabolic syndrome and type 2 diabetes. However, some recent studies on SHR/NDcp rats revealed only mild elevation of blood glucose levels. To investigate whether metabolic factors including blood glucose and histopathological alterations of SHR/NDcp rats deteriorate with a diabetogenic diet, biochemical and histopathological examinations were conducted with animals fed normal or diabetogenic diets for 20 weeks. SHR/NDcp rats receiving the normal diet displayed obesity, hypertension, hyperlipidemia, and mild elevation of blood glucose and HbA1c levels. Urinary glucose excretion was noted in only 1 out of 6 animals. Histologically, macro- and micro-vesicular steatosis in the liver, glomerular and tubular damages in the kidney and islet hyperplasia mainly of beta cells in the pancreas were characteristically noted. In SHR/NDcp rats fed the diabetogenic diet, obesity was more severe, with higher blood glucose and HbA1c levels, increased numbers of animals with urinary glucose excretion, and more pronounced hepatic steatosis and renal tubular changes. However, elevation of blood glucose levels and urinary glucose excretion proved transient. These observations indicate that the diabetic state and associated histopathological alterations in SHR/NDcp rats are exacerbated by feeding a diabetogenic diet, but the effects are limited. Elevated islet function with compensative insulin secretion might be related to amelioration of the hyperglycemic state. Further diet modification could be needed to induce a more prominent and persistent diabetic state in SHR/NDcp rats. 相似文献
23.
24.
25.
Masaya Kawaguchi Hiroki Kato Yoshifumi Noda Natsuko Suzui Tatsuhiko Miyazaki Tatsuro Furui Ken-Ichirou Morishige Masayuki Matsuo 《Diagnostic and interventional imaging》2021,102(7-8):447-453
PurposeThe purpose of this study was to determine the computed tomography (CT) and magnetic resonance imaging (MRI) characteristics of ovarian mature teratoma in patients with anti-N-methyl-d-aspartate receptor encephalitis (NMDAR-E).Materials and MethodsA total of 125 women (mean age, 40.9 ± 17.8 [SD] years; age range: 12–85 years) with 146 histopathologically or radiologically proven ovarian mature teratomas who underwent preoperative CT and MRI examinations were retrospectively included. Eight patients with 11 teratomas had NMDAR-E, whereas 117 patients with 135 teratomas did not have NMDAR-E. CT and MRI examinations were retrospectively reviewed and teratomas in patients with NMDAR-E were compared to those in patients without NMDAR-E. Comparisons were performed using Mann-Whitney U test or Fisher exact test.ResultsIn patients with NMDAR-E, maximum diameter of teratomas (26.1 ± 9.3 [SD] mm), prevalence of teeth/calcification (36%) and rate of occupation by fat components (26%) were lower than those in patients without NMDAR-E (67.0 ± 37.6 [SD] mm [P < 0.01]; 75% [P < 0.05]; and 65%[P < 0.01], respectively). More than 75% of space was occupied by fat components in 76/135 teratomas (56%) in patients without NMDAR-E, whereas this was not observed in any teratoma in patients without NMDAR-E.ConclusionBy comparison with teratomas in patients without NMDAR-E, teratomas in patients with NMDAR-E are smaller, have few teeth/calcification, and the amount of space occupied by fat components is smaller. 相似文献
26.
27.
Yuko Tsunoda Jun-ichi Sanuki Nobuhito Katayama Eisuke Fukuma Kazue Hoshi 《Surgery today》2014,44(9):1774-1777
A 37-year-old female was indicated to have a non-mass lesion in her left breast on ultrasonography (US) and visited our outpatient clinic. Mammography showed no findings of masses or microcalcification. Dynamic magnetic resonance imaging (MRI) showed a segmental enhanced lesion consisting of nodular and ring enhancement. A US-assisted vacuumed needle biopsy was performed, and the histological findings revealed sclerosing adenosis and apocrine metaplasia. After 1 year of follow-up, the MRI findings suggested both a benign lesion and ductal carcinoma in situ, and surgical excision was performed. We used a new device to evaluate the surgical margin on MRI. The non-mass lesion was excised according to the device-guided margin under local anesthesia. The histological findings revealed the features of mastopathy. Following excision, MRI showed no residual non-mass lesions, and the shape of the patient’s left breast was maintained. 相似文献
28.
29.
30.
Yasuhiro Miyake Masaharu Ando Eisuke Kaji Tatsuya Toyokawa Morihito Nakatsu Mamoru Hirohata 《Hepatology research》2008,38(10):980-986
Aim: A low platelet count leads to dose reduction of interferon (IFN) and is associated with failure to achieve a sustained virological response (SVR) in chronic hepatitis C patients. However, partial splenic embolization (PSE) is effective for treating thrombocytopenia resulting from hypersplenism. Methods: We compared the clinical features of 10 patients receiving PSE prior to the combination therapy of IFN and ribavirin (RBV) (PSE group) with those of 10 non‐receiving PSE patients (non‐PSE group). Results: In all 10 patients, PSE was successfully performed without serious adverse events. After PSE, leukocyte, neutrophil, and platelet counts significantly increased. The period from PSE to the initiation of the combination therapy was 15 (7–21) days. In the PSE group, two of six patients (33%) infected with genotype 1, and all four patients infected with genotype 2, achieved SVR. In the non‐PSE group, only three patients infected with genotype 2 achieved SVR. Two patients in the PSE group and one in the non‐PSE group discontinued the combination therapy. Three patients of the PSE group and five of the non‐PSE group reduced the dose of pegylated IFN‐α‐2b because of thrombocytopenia. In the PSE group, platelet counts during the combination therapy fell to baseline levels; however, they did not fall to lower levels than baseline levels. In the non‐PSE group, platelet counts 1 month after the initiation of the therapy were lower than baseline levels. Conclusion: The increase of platelet counts after PSE may allow the safe use of IFN and RBV and improve the SVR rate in chronic hepatitis C patients with thrombocytopenia. 相似文献