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992.
The health care supervisor responsible for establishing a therapeutic milieu within a traditional hospital organization will have greater success if these suggested management strategies are employed. Decentralizing, improving organizational communication, and clarifying interdisciplinary role relationships are the strategies that support the integration of differing organizational approaches to management. 相似文献
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Studies of the blood lipid peroxide status and vitamin E levels in patients with chronic active hepatitis and alcoholic liver disease 总被引:1,自引:0,他引:1
M Mézes A Pár P Németh T Jávor 《International journal of clinical pharmacology research》1986,6(4):333-338
As free radicals and lipid peroxidation are involved in the pathogenesis of different inflammatory diseases of the liver, the blood malondialdehyde content, the activity or quantity of free radical eliminating enzymes and the natural antioxidant, vitamin E serum level has been studied in ten patients with chronic active hepatitis and in six subjects with alcoholic liver disease. Thirty healthy volunteers served as controls. The serum malondialdehyde/thiobarbituric acid reactive substance and its concentrations increased significantly in both hepatitis groups. The superoxide dismutase content was also raised in the patients' sera. The serum glutathione peroxidase (GSH-Px) activity was decreased in both groups, while the red blood cell GSH-Px showed a significantly lower activity in the alcoholic hepatitis patients. Serum catalase activity and vitamin E levels in both types of chronic hepatitis were not significantly different from the healthy controls. 相似文献
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T. A. Fedotcheva N. L. Shimanovskii A. I. Senderovich N. S. Chermnykh A. V. Semeikin V. M. Rzheznikov L. E. Golubovskaya G. S. Grinenko V. V. Banin P. V. Sergeev 《Pharmaceutical Chemistry Journal》2007,41(7):345-349
The hormonal compound with the highest cytostatic activity against MCF-7 tumor cells (human breast cancer, BC) and the lowest
activity against normal cells (rat skin fibroblasts) was sought among gestagens, androstenes, and antiestrogencytostatics.
It was found that antiestrogencytostatics and androstenes had the highest cytostatic activity against tumor cells whereas
gestagens and antiestrogencytostatics were least active against fibroblasts. Studies of the activity of the hormonal compounds
in combination with doxorubicin on the viability of MCF-7 and rat skin fibroblasts found that all investigated compounds with
the exception of dehydroepiandrosterone (DHEA) intensify the cytostatic activity of doxorubicin against tumor cells, the greatest
effect seen for antiestrogencytostatics. A chemoprotective effect of androstenes on normal cells was noted.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 7, pp. 3–7, July, 2007. 相似文献
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