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C. Bethune W. Egner T. Garcez A. Huissoon S. Jolles Y. Karim R. Jain S. Savic K. Kelley D. Grosse-Kreul S. Grigoriadou 《Clinical and experimental immunology》2019,196(3):328-335
Common variable immunodeficiency (CVID) represents a heterogeneous group of rare disorders. There is considerable morbidity and mortality as a result of non-infectious complications, and this presents clinicians with management challenges. Clinical guidelines to support the management of CVID are urgently required. The UK Primary Immunodeficiency Network and the British Society for Immunology funded a joint project to address this. A modified Delphi Survey was conducted for the assessment, diagnosis and treatment of the non-infectious blood, respiratory, gut and liver complications of CVID. A steering group of 10 consultant immunologists and one nurse specialist developed and reviewed the survey statements and agreed the final recommendations. In total, 22 recommendations and three areas for research were developed. 相似文献
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International Retrospective Chart Review of Treatment Patterns in Severe Familial Mediterranean Fever,Tumor Necrosis Factor Receptor–Associated Periodic Syndrome,and Mevalonate Kinase Deficiency/Hyperimmunoglobulinemia D Syndrome 下载免费PDF全文
Seza Ozen Rolando Cimaz Avi Livneh Pierre Quartier Isabelle Kone‐Paut Andrew Zeft Steve Spalding Ahmet Gul Veronique Hentgen Sinisa Savic Ivan Foeldvari Joost Frenkel Luca Cantarini Dony Patel Jeffrey Weiss Nina Marinsek Ravi Degun Kathleen G. Lomax Helen J. Lachmann 《Arthritis care & research》2017,69(4):578-586
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Analysis of longitudinal ordered categorical efficacy or safety data in clinical trials using mixed models is increasingly performed. However, algorithms available for maximum likelihood estimation using an approximation of the likelihood integral, including LAPLACE approach, may give rise to biased parameter estimates. The SAEM algorithm is an efficient and powerful tool in the analysis of continuous/count mixed models. The aim of this study was to implement and investigate the performance of the SAEM algorithm for longitudinal categorical data. The SAEM algorithm is extended for parameter estimation in ordered categorical mixed models together with an estimation of the Fisher information matrix and the likelihood. We used Monte Carlo simulations using previously published scenarios evaluated with NONMEM. Accuracy and precision in parameter estimation and standard error estimates were assessed in terms of relative bias and root mean square error. This algorithm was illustrated on the simultaneous analysis of pharmacokinetic and discretized efficacy data obtained after a single dose of warfarin in healthy volunteers. The new SAEM algorithm is implemented in MONOLIX 3.1 for discrete mixed models. The analyses show that for parameter estimation, the relative bias is low for both fixed effects and variance components in all models studied. Estimated and empirical standard errors are similar. The warfarin example illustrates how simple and rapid it is to analyze simultaneously continuous and discrete data with MONOLIX 3.1. The SAEM algorithm is extended for analysis of longitudinal categorical data. It provides accurate estimates parameters and standard errors. The estimation is fast and stable. 相似文献
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Guidelines of the Croatian Society for Rheumatology for the treatment of knee and hip osteoarthritis
Grazio S Curković B Babić-Naglić D Anić B Morović-Vergles J Vlak T Gnjidić Z Kaliterna DM Novak S Kehler T Hanih M;Croatian Society for Rheumatology 《Reumatizam》2010,57(1):36-47
Osteoarthritis of the hip and the knee belongs to one of the most disabiliting conditions. Treatment goals for these patients include a reduction in pain, an improvement in joint mobility and to limit functional impairment. To properly manage osteoarthritis, both nonpharmacologic (non-interventional) and pharmacologic modalities may be employed, while minority of patients will require surgery. According to the available evidence for available therapies and experts' opinion here we present guidelines for the treatment of hip and the knee osteoarthritis in Croatia. 相似文献
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Graham P. Cook Sinisa Savic Miriam Wittmann Michael F. McDermott 《European journal of immunology》2010,40(3):631-634
A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin‐associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate. 相似文献
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