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981.
982.
Soderstrom-Anttila V; Sajaniemi N; Tiitinen A; Hovatta O 《Human reproduction (Oxford, England)》1998,13(7):2009-2015
The health, growth and development of a cohort of children (n = 59) aged 6
months to 4 years and born after oocyte donation (OD) was compared with
that from a group of children born after in-vitro fertilization (IVF) (n =
126). The study was performed by questionnaire, and the response rate was
100% in the OD group and 95% in the IVF group. All OD children were
healthy. Three IVF children had a neurological disorder. Surgical
intervention had been carried out in 8% of the OD and 13% of the IVF
children. Height and weight development were normal, and eating and
sleeping disorders were uncommon in both groups of children. The IVF
mothers more often expressed concern about the child's behaviour than did
the OD mothers. Thirty-eight percent of the OD parents and 60% of the IVF
parents intended to tell the child about the nature of its conception (P
< 0.01). Although oocyte recipients appear to have more complications
during their pregnancies than conventional IVF patients, the general health
status of OD children aged <5 years is at least as good as that of IVF
children. Growth and development in both groups of children is similar to
that of the general population.
相似文献
983.
984.
Creating empowering meaning: an interactive process of promoting health with chronically ill older Canadians 总被引:2,自引:1,他引:1
McWilliam C; Stewart M; Brown J; McNair S; Desai K; Patterson M; Del Maestro N; Pittman B 《Health promotion international》1997,12(2):111-123
Many health promotion approaches afford education about disease prevention
and enhancement of one's health status. But strategies for enabling older
people with chronic illness to better mobilize their resources for everyday
living still require development. This practical action research study
explored the experiences of 13 purposefully selected older persons who
participated in a health promotion intervention premised on the adult
education theory of perspective transformation. Findings illuminate health
promotion through a holistic interactive process in which professional and
chronically ill older person together evolved a caring relationship and
enhanced conscious awareness of life and health experiences. Five
health-promoting strategies were identified: building trust and meaning;
connecting; caring; mutual knowing; and mutual creating. Researchers
suggest several important directions to refine professional practice
approaches and health care delivery systems in order to promote the health
of older persons with chronic conditions. 相似文献
985.
The dipeptides Gly-Pro and Pro-Gly, glycine, and proline do not affect contractile activity of the Straub cardiac preparation
of the frog. Gly-Pro and glycine augment, while Pro-Gly moderates the effects of acetylcholine. The effect of proline was
insignificant. Equimolar amino acid mixtures and mixtures of the dipeptides decrease the effects of acetylcholine. Direction
and the degree of Gly-Pro effect attests to specific action of this peptide on cardiac activity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 8, pp. 139–141, August, 1998 相似文献
986.
蓖麻油引产餐对妊娠大鼠分娩的影响 总被引:5,自引:0,他引:5
目的蓖麻油引产餐用于妊娠晚期引产效果明显,但其作用机制不清楚。本研究通过引产餐灌服妊娠大鼠建立动物引产模型,以期了解引产餐对妊娠大鼠分娩启动和产程的影响,并初步探讨蓖麻油引产餐活性成份。方法于大鼠妊娠第18~20天灌服引产餐,观察大鼠分娩启动和分娩产程变化。利用高压液相分析蓖麻油和蓖麻油引产餐中脂肪酸成份。结果引产餐可提前妊娠大鼠分娩启动时间,缩短分娩产程。蓖麻油引产餐和蓖麻油两者脂肪酸对比结果显示,成份相同,蓖麻酸均占90%,未见花生四烯酸成份。结论引产餐对妊娠晚期大鼠具有引产、催产作用,可以利用引产餐灌服妊娠大鼠建立动物引产模型。推测蓖麻酸是引产餐启动分娩和缩短产程的活性物质。 相似文献
987.
988.
Comparisons between Antimicrobial Pharmacodynamic Indices and Bacterial Killing as Described by Using the Zhi Model 总被引:5,自引:1,他引:4
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S. Corvaisier P. H. Maire M. Y. Bouvier dyvoire X. Barbaut N. Bleyzac R. W. Jelliffe 《Antimicrobial agents and chemotherapy》1998,42(7):1731-1737
Various suggestions have been made for empirical pharmacodynamic indices of antibiotic effectiveness, such as areas under the drug concentration-time curve in serum (AUC), AUC>MIC, AUC/MIC, area under the inhibitory curve (AUIC), AUC above MIC, and time above MIC (T>MIC). In addition, bacterial growth and killing models, such as the Zhi model, have been developed. The goal of the present study was to compare the empirical behavior of the Zhi model of bacterial growth and killing with the other empirical pharmacodynamic indices described above by using simulated clinical data analyzed with the USC*PACK PC clinical programs for adaptive control of drug therapy, with one model describing a concentration-dependent antibiotic (tobramycin) and another describing a concentration-independent antibiotic (ticarcillin). The computed relative number of CFU was plotted against each pharmacodynamic index, with each axis parameterized over time. We assumed that a good pharmacodynamic index should present a clear and continuous relationship between the time course of its values and the time course of the bacterial killing as seen with the Zhi model. Preliminary work showed that some pharmacodynamic indices were very similar. A good sensitivity to the change in the values of the MIC was shown for AUC/MIC and also for T>MIC. In addition, the time courses of some other pharmacodynamic indices were very similar. Since AUC/MIC is easily calculated and shows more sensitivity, it appeared to be the best of the indices mentioned above for the concentration-dependent drug, because it incorporated and used the MIC the best. T>MIC appeared to be the best index for a concentration-independent drug. We also propose a new composite index, weighted AUC (WAUC), which appears to be useful for both concentration-dependent and concentration-independent drugs. 相似文献
989.
BACKGROUND: The etiology of thrombotic thrombocytopenic purpura (TTP) remains undetermined. TTP has been associated with a number of secondary causes including infections, drugs, menses, pregnancy, autoimmune diseases, and bone marrow transplantation. Regardless of the inciting factors, it is widely accepted that endothelial injury and platelet aggregation are integral components. The morbidity and mortality have been significantly reduced with the use of plasmapheresis. However, refractory forms of TTP remain a clinical management challenge. Refractory TTP has not previously been associated with occult bacterial infection. CASE REPORT: Two patients had classic TTP that was refractory to daily plasma exchange with fresh-frozen plasma. Multiple attempts over a period of months to wean these patients off plasma exchange resulted in exacerbations of disease activity, as indicated by increased schistocytosis, decreased hematocrit, increased serum lactate dehydrogenase, and decreased platelet counts. Both patients were empirically treated for infections during hospitalization, although microbial cultures failed to isolate an organism. Discontinuation of antimicrobial therapy on multiple occasions in one patient was associated with recurrence of disease. In the other patient, dental extraction with drainage of an occult periodontal abscess resulted in sustained remission of disease. CONCLUSION: Occult bacterial infection may play a role in triggering and sustaining TTP that is refractory to conventional treatment. A careful search for such an infection and appropriate antimicrobial therapy should be considered in the management of these patients. 相似文献
990.