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Ceravolo R Volterrani D Frosini D Bernardini S Rossi C Logi C Manca G Kiferle L Mariani G Murri L Bonuccelli U 《Journal of neural transmission (Vienna, Austria : 1996)》2006,113(11):1787-1790
Summary. Several evidences suggest that cholinergic deficits may significantly contribute to dementia in Parkinson’s disease (PDD)
and acetylcholinesterase inhibitors (ChEIs) have been reported to improve cognitive symptoms in PDD, without worsening parkinsonism.
Nineteen PDD patients underwent brain perfusion SPECT with 99mTc-ethyl cysteinate dimer after 6 months ChEIs treatment in order to evaluate the functional correlates of clinical improvement.
A clear-cut cognitive improvement was reported in PDD patients with a significant improvement of ADAS-cog total score as well
as of subscores exploring executive functions (p < 0.01). MMSE total score did not significantly change after ChEIs but the subscore of attention significantly improved after
therapy (p < 0.01). No difference in motor performance as evaluated by UPDRS was reported. SPM analysis showed a significant increase
of perfusion (p < 0.0001) in bilateral cingulate, and frontal regions after ChEIs. Our data confirm the efficacy of ChEIs in the treatment
of dementia associated with PD mainly on attention and executive functions, and the functional findings indicate that this
cognitive improvement could be associated with a sort of pharmacological frontal “re-afferentation”. 相似文献
74.
Ferdinando Iellamo Vincenzo Manzi Giuseppe Caminiti Cristiana Vitale Carlo Castagna Michele Massaro Alessio Franchini Giuseppe Rosano Maurizio Volterrani 《International journal of cardiology》2013
Background
The best format of exercise training in patients with chronic heart failure (CHF) is controversial. We tested the hypothesis that aerobic continuous training (ACT) and aerobic interval training (AIT) induce similar effects on functional capacity, central hemodynamics and metabolic profile in patients with postinfarction CHF provided that the training load is equated by an individually-tailored volume/intensity dose of exercise.Methods
Twenty patients with postinfarction CHF under optimal medical treatment were randomized to ACT or AIT for 12 weeks. Exercise training consisted in individualized loads prescribed according to the Training Impulses (TRIMPi) method, which was determined using the individual HR and lactate profiling obtained during a treadmill test at baseline.Results
Peak VO2 increased significantly by 22% with both ACT and AIT, without differences between the two training programs. Changes in anaerobic threshold and VE/VCO2 slope were not significantly different between ACT and AIT. Resting HR significantly decreased with both exercise modes. Resting cardiac output and stroke volume, left ventricular diastolic dimension and ejection fraction did not change from baseline with both exercise modes. Lipid profile and glucose metabolism were not substantially altered by ACT and AIT.Conclusions
ACT and AIT both induce significant improvement in aerobic capacity in patients with postinfarction CHF, without significant differences between the two training modes, provided that patients are trained at the same, individually tailored, dose of exercise. The TRIMPi method might represent a step forward in the individualization of an aerobic training tailored to the patient's clinical and functional status within cardiac rehabilitation programs. 相似文献75.
Sebastiani F Barberio C Casalone E Cavalieri D Polsinelli M 《Research in microbiology》2002,153(1):53-58
Crossings between strains of Saccharomyces cerevisiae and Saccharomyces bayanus were carried out. Genetic, molecular and electrophoretic karyotyping data indicated that interspecific hybrids were obtained. The hybrid cells segregated "grande" and "petite" colonies, and the latter ranged between 20 and 50%; unlike "grande" colonies, "petite" colonies did not sporulate and did not ferment maltose. In the hybrids, the extent of sporulation varied between 10 and 20%; only very rare asci (around 10(-4)) held viable ascospores. Clones from the viable ascospores sporulated and produced asci with viable ascospores able to give mating with spores from both hybrid derivatives and parental species. Fertile asci could derive from allotetraploid cells generated by endomitotic events in allodiploid cells, a mechanism that enables overcoming the species barrier between S. cerevisiae and S. bayanus. 相似文献
76.
Marazzi G Iellamo F Volterrani M Lombardo M Pelliccia F Righi D Grieco F Cacciotti L Iaia L Caminiti G Rosano G 《Advances in therapy》2012,29(1):64-70
Introduction
Self-monitoring home blood pressure (BP) devices are currently recommended for long-term follow-up of hypertension and its management. Some of these devices are integrated with algorithms aimed at detecting atrial fibrillation (AF), which is common essential hypertension. This study was designed to compare the diagnostic accuracy of two widely diffused home BP monitoring devices in detecting AF in an unselected population of outpatients referred to a hypertension clinic because of high BP.Methods
In 503 consecutive patients the authors simultaneously compared the accuracy of the Microlife? BP A200 Plus (Microlife) and the OMRON? M6 (OMRON) home BP devices, in detecting AF.Results
Systolic and diastolic BP as well as heart rate (HR) values detected by the two devices were not significantly different. Pulse irregularity was detected in 124 and 112 patients with the OMRON M6 and Microlife BP A200 Plus devices, respectively. Simultaneous electrocardiogram (ECG) recording revealed that pulse irregularity was due to AF in 101 patients. Pulse irregularity detected by the OMRON M6 device corresponded to AF in 101, to supraventricular premature beats in 18, and to frequent premature ventricular beat in five patients, respectively. Pulse irregularity detected by the Microlife BP A200 Plus device corresponded to AF in 93, to supraventricular premature beats in 14, and to ventricular premature beats in five patients. The sensitivity for detecting AF was 100%, the specificity was 92%, and diagnostic accuracy 95% for the OMRON M6 and 100%, 92%, and 95 for the Microlife BP A200 Plus, respectively. AF was newly diagnosed by ECG recordings in 47 patients, and was detected in all patients by the OMRON device, and in 42 patients by the Microlife device.Conclusion
These results indicate that OMRON M6 is more accurate than Microlife BP A200 Plus in detecting AF in patients with essential hypertension. Widespread use of these devices in hypertensive patients could be of clinical benefit for the early diagnosis and treatment of this arrhythmia and related consequences. 相似文献77.
Cordelli DM Aldrovandi A Gentile V Garone C Conti S Aceti A Gennaro E Zara F Franzoni E 《Seizure》2012,21(2):141-143
PurposeTo examine fever as a precipitating factor for focal seizures in patients with Panayiotopoulos syndrome (PS) and evaluate the role of SCN1A in PS patients with seizures triggered by fever.MethodsFrom January 2000 to June 2008, we identified patients referred for seizures who fulfilled the criteria of PS. Patients were divided into two groups, according to the presence (group A) or the absence (group B) of seizures triggered by fever. Electroclinical features of the two groups were compared. In addition, an analysis of SCN1A in patients of group A was performed.ResultsThirty patients fulfilled the inclusion criteria. Eleven patients (36%) had at least one focal autonomic seizure triggered by fever (group A). In group A, 7/11 patients (63.5%) had the first focal autonomic seizure during a febrile illness. Two of these 7 patients were misdiagnosed at the onset of PS. The median age at the onset of PS was slightly lower in group A than in group B (p = .050). Moreover, patients in group A more frequently had a positive familial history of febrile seizures (FS) (p = .047). No mutations of SCN1A were found in any of the 10 patients screened.ConclusionFever is a common trigger for focal autonomic seizures in PS. Knowing that an autonomic manifestation during fever can be an epileptic seizure could facilitate diagnosis and prevent unnecessary investigations and erroneous treatments. Moreover, our data show that SCN1A gene does not contribute significantly to susceptibility to autonomic seizures during fever in patients with PS. 相似文献
78.
Giuseppe G. Loscocco Francesco Mannelli Paola Guglielmelli Chiara Paoli Ilaria Marone Rosalba Cucci Giacomo Coltro Benedetta Sordi Francesco Albano Massimo Breccia Valerio De Stefano Guido Finazzi Alessandra Iurlo Bruno Martino Francesca Palandri Francesco Passamonti Sergio Siragusa Lara Mannelli Duccio Fantoni Paola Fazi Sergio Amadori Marco Vignetti Tiziano Barbui Alessandro M. Vannucchi 《American journal of hematology》2019,94(9):E239-E242
79.
Michele Senni John J.V. McMurray Rolf Wachter Hugh F. McIntyre Antonio Reyes Ivan Majercak Peter Andreka Nina Shehova‐Yankova Inder Anand Mehmet B. Yilmaz Harinder Gogia Manuel Martinez‐Selles Steffen Fischer Zsolt Zilahi Franco Cosmi Valeri Gelev Enrique Galve Juanjo J. Gómez‐Doblas Jan Nociar Maria Radomska Beata Sokolova Maurizio Volterrani Arnab Sarkar Bernard Reimund Fabian Chen Alan Charney 《European journal of heart failure》2016,18(9):1193-1202
80.