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991.
Henry Ahn Payam Mousavi Lee Chin Sandra Roth Joel Finkelstein Alex Vitken Cari Whyne 《European spine journal》2007,16(8):1171-1178
A biomechanical study comparing simulated lytic vertebral metastases treated with laser-induced thermotherapy (LITT) and vertebroplasty
versus vertebroplasty alone. To investigate the effect of tumor ablation using LITT prior to vertebroplasty on biomechanical
stability and cement fill patterns in a standardized model of spinal metastatic disease. Vertebroplasty in the metastatic
spine is aimed at reducing pain, but is associated with risk of cement extravasation in up to 10%. Six pairs of fresh-frozen
cadaveric thoracolumbar spinal motion segments were tested in axial compression intact, with simulated metastases and following
percutaneous vertebroplasty with or without LITT. Canal narrowing under load, pattern of cement fill, load to failure, and
LITT temperature and pressure generation were collected. In all LITT specimens, cement filled the defect without extravasation.
The canal extravasation rate was 33% in specimens treated without LITT. LITT and vertebroplasty yielded a trend toward improved
posterior wall stability (P = 0.095) as compared to vertebroplasty alone. Moderate rises in temperature and minimal pressure generation was seen during
LITT. In this model, elimination of tumor by LITT, facilitates cement fill, enhances biomechanical stability and reduces the
risk of cement extravasation. 相似文献
992.
Howard B. Yeon Jacob Weinberg Vincent Arlet Jean A. Ouelett Kirkham B. Wood 《European spine journal》2007,16(9):1379-1385
Fifteen skeletally immature patients with double major adolescent idiopathic scoliosis with large lumbar curves and notable L4 and L5 coronal plane obliquity were retrospectively studied. Seven patients who underwent anterior release and fusion of the lumbar curve with segmental anterior instrumentation and subsequent posterior instrumentation ending at L3 were compared with eight patients treated with anterior release and fusion without anterior instrumentation followed by posterior instrumentation to L3 or L4. At 4.5 years follow-up (range 2.5-7 years), curve correction, coronal balance and fusion rate were not statistically different between the two groups; however, the group with anterior instrumentation had improved coronal plane, near normalangulation in the distal unfused segment compared with the group without anterior instrumentation. In cases involving severe lumbar curvatures in the context of double major scoliosis, when as a first stage anterior release is chosen, the addition of instrumentation appears to restore normal coronal alignment of the distal unfused lumbar segment, and may in certain cases save a level compared with traditional fusions to L4. 相似文献
993.
Recessive dystrophic epidermolysis bullosa (RDEB) is an uncommon and severe disorder characterised by trauma-induced blisters, intractable skin ulcers, scarring, milia, and nail dystrophy. We report the good result of both surgical release of fingers allowing spontaneous epithelisation without skin grafting and post-operative meticulous skin care without splinting, followed-up for one year. 相似文献
994.
Seok Hyun Cho Hyun Jung Min Hong Xiu Han Seung Sam Paik Kyung Rae Kim 《Otolaryngology--head and neck surgery》2006,135(3):404-408
OBJECTIVE: To evaluate the findings of computed tomography (CT) and histopathology of the bulla ethmoidalis as objective markers of bone remodeling in chronic rhinosinusitis (CRS). METHODS: Preoperative ostiomeatal unit (OMU) scans and histopathologic findings of the bulla ethmoidalis were performed on 23 patients (39 sides) undergoing endoscopic sinus surgery for CRS. Lund-Mackay scores and Hounsfield units (HU) of the bulla were checked in coronal CT scans. The pathologist graded the severities of the mucosal and bony changes in histopathology. Statistical analysis was performed using Mann-Whitney U test and Spearman correlation coefficient (r). RESULTS: The HU values of the bulla were significantly increased with higher Lund-Mackay scores in OMU CT (r = 0.405, P = 0.01). The bony grades in histopathology were significantly increased with higher mucosal grades (r = 0.821, P = 0.0001). These findings in CT scans and histopathology were well correlated with each other (r > 0.3, P < 0.05). CONCLUSION: HU may be a useful objective marker of bone remodeling in chronic rhinosinusitis. 相似文献
995.
Background
Official guidelines that promote evidence-based and cost-effective prescribing are of main relevance for obvious reasons. However, to what extent these guidelines are followed and their conditioning factors at different levels of the health care system are still insufficiently known. 相似文献996.
Oskar Meggeneder 《Zeitschrift fur Gesundheitswissenschaften》2007,15(2):101-107
In a small company, the whole company culture, including the management style, is dominated by the owner. The management culture
in small companies and above all the management style of the owner determine the chances of successfully introducing workplace
health promotion (WHP). For this reason a typology was developed that describes the management personalities who affect the
company culture in small enterprises. This provides a guide to the possible success of WHP in connection with the management
style. Although a summary of the management and corporate culture of small companies in a few categories cannot show the variety
of social reality, it can provide orientation. The typical categories of company social order (a mixture of ownership and
leadership) in small and medium-sized enterprises are given below. Furthermore, there is an assessment of what the chances
of realising workplace health promotion are in each type of company. Small and medium-sized companies (SME) have a number
of organisational characteristics which are just ideal for the introduction and implementation of workplace health promotion.
The work of the employer and employees is often the same. Information in the company is generally comprehensive and easily
available. The lack of information which employees often complain about in large companies is not a problem. There is a good
flow of communication. Small companies have a flat hierarchy that enables participation, the essential requirement for WHP.
There is a close social relationship between the company head and the workforce, although it must be said that this closeness
can be dangerous, particularly if it is misused as complete social control. The readiness to implement Workplace Health Promotion
(WHP) in SME and the degree of success depends largely on the personality of the company manager and the style of leadership.
Considering the importance of a manager’s personality for WHP in SME, modules and instruments to assist company owners and
managers in SME are to be developed. On behalf of and in co-operation with the Austrian Network for Workplace Health Promotion
several modules have been introduced to assist owners and managers of SMEs. 相似文献
997.
Wendy J Sturtz Kathleen H Leef Amy B Mackley Shailja Sharma Teodoro Bottiglieri David A Paul 《BMC pediatrics》2007,7(1):38
Background
The purpose of this study was to characterize total homocysteine (tHcy) levels at birth in preterm and term infants and identify associations with intraventricular hemorrhage (IVH) and other neonatal outcomes such as mortality, sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, and thrombocytopenia. 相似文献998.
999.
Fredrik Ghosh Karl Engelsberg Robert V. English Robert M. Petters 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(6):835-846
Background The purpose of this study was to explore neuroretinal transplantation in a large animal model of severe retinitis pigmentosa
and to establish graft development, long-term survival, graft-host integration, and effects on the host retina.
Methods Rhodopsin transgenic pigs, aged 6 months, received in one eye a fetal full-thickness neuroretinal sheet in the subretinal
space by means of vitrectomy and retinotomy. Six months postoperatively, eyes were studied in the light microscope and with
immunohistochemical markers. Full-field electroretinography (ERG) was performed at 4 and 6 months.
Results Laminated grafts with well-organized photoreceptors, rod bipolar cells, and Müller cells were found in five of six eyes. Neuronal
connections between graft and host retina were not seen. In the five eyes containing a graft, the number of surviving rods
in the host retina was significantly higher compared with unoperated eyes. The ERG did not reveal any significant difference
in b-wave amplitude between operated and control eyes, but the cone-derived response in operated eyes increased significantly
from 4 to 6 months while the rod response in control eyes decreased significantly.
Conclusions Fetal full-thickness neuroretina can be transplanted safely to an eye with severe retinal degeneration. In their major part,
the transplants develop a normal laminated morphology and survive for at least 6 months. Graft and host retinal neurons do
not form connections. Retinal function in the host is reduced initially by the surgical trauma, but the presence of a well-laminated
graft counteracts this effect and rescues rods from degeneration.
Supported by The Foundation Fighting Blindness (grant# C-NC02-798-0078), The Faculty of Medicine, University of Lund, The
Swedish Research Council, The Princess Margaretas Foundation for Blind Children, The 2nd ONCE International Award for New
Technologies for the Blind. 相似文献
1000.