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81.
Serum Antibodies to Porphyromonas gingivalis Chaperone HtpG Predict Health in Periodontitis Susceptible Patients
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82.
Gwynnyth Llewellyn David McConnell Domenica Russo Rachel Mayes Anne Honey 《Journal of Applied Research in Intellectual Disabilities》2002,15(4):341-353
Background Increasing emphasis is being given to carrying out parent education programmes at home with widely reported benefits. The purpose of this paper is to draw lessons for practitioners from implementing a randomized trial of a home‐based parent education programme for parents with intellectual disabilities that addressed child health and safety issues. Methods A thematic analysis of case notes and parent feedback from the 45 parent participants in this programme was conducted prior to two team sessions to discuss the findings. Results Programme‐specific issues included format, content and presentation style. Themes relevant to home‐based programmes for parents with intellectual disabilities more generally included the suitability of the home as a learning environment; identifying parent priorities; parent readiness to learn; and parent control (or lack of) over the home environment. In addition, practice points for parent educators were identified. Conclusions The home environment benefits both teaching and learning, however, as this paper highlights careful consideration needs to be given to each parent‐learner's home situation. We recommend that in future the processes involved in home‐based programmes be reported alongside programme outcomes. 相似文献
83.
84.
Symptomatic and presumed symptomatic focal epilepsies in childhood: An observational,prospective multicentre study
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Marilena Vecchi Carmen Barba Debora De Carlo Micol Stivala Renzo Guerrini Emilio Albamonte Domiziana Ranalli Domenica Battaglia Giada Lunardi Clementina Boniver Benedetta Piccolo Francesco Pisani Gaetano Cantalupo Giuliana Nieddu Susanna Casellato Silvia Cappanera Elisabetta Cesaroni Nelia Zamponi Domenico Serino Lucia Fusco Alessandro Iodice Filippo Palestra Lucio Giordano Elena Freri Ilaria De Giorgi Francesca Ragona Tiziana Granata Isabella Fiocchi Stefania Maria Bova Massimo Mastrangelo Alberto Verrotti Sara Matricardi Elena Fontana Davide Caputo Francesca Darra Bernardo Dalla Bernardina Francesca Beccaria Giuseppe Capovilla Maria Pia Baglietto Alessandra Gagliardi Aglaia Vignoli Maria Paola Canevini Egle Perissinotto Stefano Francione 《Epilepsia》2016,57(11):1808-1816
85.
Deborah M. Rooney David M. Hananel Benjamin J. Covington Patrick L. Dionise Michael T. Nykamp Melvin Pederson Jamal M. Sahloul Rachael Vasquez F. Jacob Seagull Harold M. Pinsky Domenica G. Sweier James M. Cooke 《Surgery》2018,163(4):927-932
Background
Currently there is no reliable, standardized mechanism to support health care professionals during the evaluation of and procurement processes for simulators. A tool founded on best practices could facilitate simulator purchase processes.Methods
In a 3-phase process, we identified top factors considered during the simulator purchase process through expert consensus (n?=?127), created the Simulator Value Index (SVI) tool, evaluated targeted validity evidence, and evaluated the practical value of this SVI. A web-based survey was sent to simulation professionals. Participants (n?=?79) used the SVI and provided feedback. We evaluated the practical value of 4 tool variations by calculating their sensitivity to predict a preferred simulator.Results
Seventeen top factors were identified and ranked. The top 2 were technical stability/reliability of the simulator and customer service, with no practical differences in rank across institution or stakeholder role. Full SVI variations predicted successfully the preferred simulator with good (87%) sensitivity, whereas the sensitivity of variations in cost and customer service and cost and technical stability decreased (≤54%). The majority (73%) of participants agreed that the SVI was helpful at guiding simulator purchase decisions, and 88% agreed the SVI tool would help facilitate discussion with peers and leadership.Conclusion
Our findings indicate the SVI supports the process of simulator purchase using a standardized framework. Sensitivity of the tool improved when factors extend beyond traditionally targeted factors. We propose the tool will facilitate discussion amongst simulation professionals dealing with simulation, provide essential information for finance and procurement professionals, and improve the long-term value of simulation solutions. Limitations and application of the tool are discussed. 相似文献86.
87.
Dissociating neural correlates for nouns and verbs 总被引:5,自引:0,他引:5
Shapiro KA Mottaghy FM Schiller NO Poeppel TD Flüss MO Müller HW Caramazza A Krause BJ 《NeuroImage》2005,24(4):407-1067
Dissociations in the ability to produce words of different grammatical categories are well established in neuropsychology but have not been corroborated fully with evidence from brain imaging. Here we report on a PET study designed to reveal the anatomical correlates of grammatical processes involving nouns and verbs. German-speaking subjects were asked to produce either plural and singular nouns, or first-person plural and singular verbs. Verbs, relative to nouns, activated a left frontal cortical network, while the opposite contrast (nouns-verbs) showed greater activation in temporal regions bilaterally. Similar patterns emerged when subjects performed the task with pseudowords used as nouns or as verbs. These results converge with findings from lesion studies and suggest that grammatical category is an important dimension of organization for knowledge of language in the brain. 相似文献
88.
Claudio Ponticelli Khaled M. Musallam Paolo Cianciulli Maria Domenica Cappellini 《Blood reviews》2010
Increased survival in patients with β thalassaemia major (TM) allowed for several morbidities to manifest. Renal manifestations of the disease and its treatment have been poorly evaluated. There is evidence, mainly from studies in the paediatric population, of tubular dysfunction and glomerular filtration rate abnormalities in this patient population. Long-term outcomes of these changes, however, have not been prospectively investigated. The pathogenesis of these abnormalities could be attributed to iron overload, too aggressive iron removal, and/or the underlying anaemia. These changes seem to be nonprogressive, resolve spontaneously in most part, or may require iron chelator dose modifications. Relative iron depletion may explain renal function changes attributed to chelation therapy; thus, sudden removal of iron or overchelation should be avoided. Future studies should aim to evaluate the natural history of kidney function in TM patients to help understand the mechanisms and long-term sequelae of the observed renal changes. 相似文献
89.
Gavello D Vandael DH Cesa R Premoselli F Marcantoni A Cesano F Scarano D Fubini B Carbone E Fenoglio I Carabelli V 《Nanotoxicology》2012,6(1):47-60
We studied the effects of multi-walled carbon nanotubes (MWCNTs) on the electrophysiological properties of cultured mouse chromaffin cells, a model of spontaneously firing cells. The exposure of chromaffin cells to MWCNTs at increasing concentrations (30-263 μg/ml) for 24 h reduced, in a dose-dependent way, both the cell membrane input resistance and the number of spontaneously active cells (from 80-52%). Active cells that survived from the toxic effects of MWCNTs exhibited more positive resting potentials, higher firing frequencies and unaltered voltage-gated Ca(2+), Na(+) and K+ current amplitudes. MWCNTs slowed down the inactivation kinetics of Ca(2+)-dependent BK channels. These electrophysiological effects were accompanied by MWCNTs internalization, as confirmed by transmission electron microscopy, indicating that most of the toxic effects derive from a dose-dependent MWCNTs-cell interaction that damages the spontaneous cell activity. 相似文献
90.
Slow repetitive TMS for drug-resistant epilepsy: clinical and EEG findings of a placebo-controlled trial 总被引:5,自引:0,他引:5
Cantello R Rossi S Varrasi C Ulivelli M Civardi C Bartalini S Vatti G Cincotta M Borgheresi A Zaccara G Quartarone A Crupi D Laganà A Inghilleri M Giallonardo AT Berardelli A Pacifici L Ferreri F Tombini M Gilio F Quarato P Conte A Manganotti P Bongiovanni LG Monaco F Ferrante D Rossini PM 《Epilepsia》2007,48(2):366-374
PURPOSE: To assess the effectiveness of slow repetitive transcranial magnetic stimulation (rTMS) as an adjunctive treatment for drug-resistant epilepsy. METHODS: Forty-three patients with drug-resistant epilepsy from eight Italian Centers underwent a randomized, double-blind, sham-controlled, crossover study on the clinical and EEG effects of slow rTMS. The stimulus frequency was 0.3 Hz. One thousand stimuli per day were given at the resting motor threshold intensity for 5 consecutive days, with a round coil at the vertex. RESULTS: "Active" rTMS was no better than placebo for seizure reduction. However, it decreased interictal EEG epileptiform abnormalities significantly (p < 0.05) in one-third of the patients, which supports a detectable biologic effect. No correlation linked the rTMS effects on seizure frequency to syndrome or anatomic classification, seizure type, EEG changes, or resting motor threshold (an index of motor cortex excitability). CONCLUSIONS: Although the antiepileptic action was not significant (p > 0.05), the individual EEG reactivity to "active" rTMS may be encouraging for the development of more-powerful, noninvasive neuromodulatory strategies. 相似文献