全文获取类型
收费全文 | 724篇 |
免费 | 50篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 15篇 |
妇产科学 | 13篇 |
基础医学 | 73篇 |
口腔科学 | 25篇 |
临床医学 | 108篇 |
内科学 | 166篇 |
皮肤病学 | 38篇 |
神经病学 | 33篇 |
特种医学 | 89篇 |
外国民族医学 | 1篇 |
外科学 | 55篇 |
综合类 | 37篇 |
预防医学 | 34篇 |
眼科学 | 2篇 |
药学 | 45篇 |
中国医学 | 1篇 |
肿瘤学 | 40篇 |
出版年
2022年 | 19篇 |
2021年 | 15篇 |
2020年 | 10篇 |
2019年 | 15篇 |
2018年 | 16篇 |
2017年 | 14篇 |
2016年 | 13篇 |
2015年 | 17篇 |
2014年 | 23篇 |
2013年 | 25篇 |
2012年 | 15篇 |
2011年 | 19篇 |
2010年 | 32篇 |
2009年 | 30篇 |
2008年 | 13篇 |
2007年 | 19篇 |
2006年 | 20篇 |
2005年 | 12篇 |
2004年 | 11篇 |
2003年 | 14篇 |
2002年 | 12篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 8篇 |
1998年 | 22篇 |
1997年 | 14篇 |
1996年 | 24篇 |
1995年 | 18篇 |
1994年 | 27篇 |
1993年 | 28篇 |
1992年 | 15篇 |
1990年 | 10篇 |
1989年 | 18篇 |
1988年 | 17篇 |
1987年 | 12篇 |
1986年 | 11篇 |
1985年 | 15篇 |
1983年 | 10篇 |
1982年 | 11篇 |
1981年 | 9篇 |
1980年 | 11篇 |
1979年 | 11篇 |
1978年 | 7篇 |
1977年 | 8篇 |
1975年 | 6篇 |
1957年 | 9篇 |
1955年 | 6篇 |
1954年 | 6篇 |
1949年 | 8篇 |
1948年 | 8篇 |
排序方式: 共有777条查询结果,搜索用时 0 毫秒
11.
12.
Epilepsy surgery has emerged as an important option in the treatment of children with epilepsy that is refractory to antiepileptic drug management. The cornerstone of successful surgery is accurate localization of the brain region of seizure onset. Traditional techniques of seizure onset localization, e.g. surface electroencephalography (EEG) recording and magnetic resonance imaging (MRI), allow accurate localization in a significant number of patients. When the focus of seizure onset is not apparent from these non-invasive techniques, other methods of localization, e.g. intracranial EEG recording, may be needed before resection of the focus. Single-photon emission computed tomography (SPECT) is a nuclear medicine blood-flow technique that has been used to identify a region of epileptogenic brain associated with low blood flow in the resting state (interictal SPECT) or increased blood flow at the time of seizure activity (ictal SPECT). This report describes the validation and utility of a computer-assisted method of subtracting the interictal from the ictal SPECT scans and co-registering the difference image on the MRI. This method, called subtraction ictal SPECT co-registered on MRI (SISCOM), is used in guiding the location and the extent of intracranial electrode implantation, or in obviating the need for the implantation in some cases. 相似文献
13.
M.F. MANJI I. AL BADAWI† A. EL ENBABY & N. AL BAREEDY† 《International journal of gynecological cancer》2006,16(2):675-680
Female circumcision is a traditional practice common in African countries. It involves partial or total removal of external female genitalia. It has led to many complications, in particular, the scarring of the external genitalia. The consequence is a very narrow introitus making the intracavitary brachytherapy treatment component difficult when these women develop cancer of cervix. We present two such cases from our institution. Our aim is to make the radiation and gynecological oncologists, both in developed and developing countries, aware of this practice and the problems they can encounter in the management of such cases. Intracavitary brachytherapy is an important component in the potentially curative role of radiation therapy for cervical cancer. Every effort should be made to ensure that the sequelae of genital mutilation does not deprive these women of the same standard of care as the general population. 相似文献
14.
Acute otomastoiditis and its complications: role of CT 总被引:2,自引:0,他引:2
Acute bacterial (suppurative) otomastoiditis responds to antibiotic treatment; radiologic study is required only when there is clinical suggestion of coalescent mastoiditis, intracranial complications, or an underlying chronic disease. Computed tomography (CT) is the method of choice for evaluating otogenic intra- or extra-cranial complications. CT scans can show stages of disease progression when infection has spread by way of soft tissue, blood, and bone pathways into the dural venous sinuses, meninges, labyrinth, facial nerves, epidural and other intracranial spaces. When there is clinical suggestion of acute coalescent mastoiditis, a CT scan of the temporal bone can confirm the presence of rarefying osteitis, coalescence of the air cells, and subperiosteal abscess. 相似文献
15.
Charlotte W Ockeloen Marjolein H Willemsen Sonja de Munnik Bregje WM van Bon Nicole de Leeuw Aad Verrips Sarina G Kant Elizabeth A Jones Han G Brunner Rosa LE van Loon Eric EJ Smeets Mieke M van Haelst Gijs van Haaften Ann Nordgren Helena Malmgren Giedre Grigelioniene Sascha Vermeer Pedro Louro Lina Ramos Thomas JJ Maal Celeste C van Heumen Helger G Yntema Carine EL Carels Tjitske Kleefstra 《European journal of human genetics : EJHG》2015,23(9):1270-1185
Loss-of-function variants in ANKRD11 were identified as the cause of KBG syndrome, an autosomal dominant syndrome with specific dental, neurobehavioural, craniofacial and skeletal anomalies. We present the largest cohort of KBG syndrome cases confirmed by ANKRD11 variants reported so far, consisting of 20 patients from 13 families. Sixteen patients were molecularly diagnosed by Sanger sequencing of ANKRD11, one familial case and three sporadic patients were diagnosed through whole-exome sequencing and one patient was identified through genomewide array analysis. All patients were evaluated by a clinical geneticist. Detailed orofacial phenotyping, including orthodontic evaluation, intra-oral photographs and orthopantomograms, was performed in 10 patients and revealed besides the hallmark feature of macrodontia of central upper incisors, several additional dental anomalies as oligodontia, talon cusps and macrodontia of other teeth. Three-dimensional (3D) stereophotogrammetry was performed in 14 patients and 3D analysis of patients compared with controls showed consistent facial dysmorphisms comprising a bulbous nasal tip, upturned nose with a broad base and a round or triangular face. Many patients exhibited neurobehavioural problems, such as autism spectrum disorder or hyperactivity. One-third of patients presented with (conductive) hearing loss. Congenital heart defects, velopharyngeal insufficiency and hip anomalies were less frequent. On the basis of our observations, we recommend cardiac assessment in children and regular hearing tests in all individuals with a molecular diagnosis of KBG syndrome. As ANKRD11 is a relatively common gene in which sequence variants have been identified in individuals with neurodevelopmental disorders, it seems an important contributor to the aetiology of both sporadic and familial cases. 相似文献
16.
17.
Khadija EL. Mouaden D.S. Chauhan M.A. Quraishi Lahcen Bazzi 《Sustainable Chemistry and Pharmacy》2020
A facile single-step synthesis was performed to cross-link chitosan with thiocarbohydrazide to yield thiocarbohydrazide-chitosan (TC-Cht) which was for the first time evaluated as an inhibitor for corrosion of stainless steel in 3.5% NaCl solution. A comprehensive electrochemical analysis employing electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP), and cyclic voltammetry (CV) was undertaken and showed that the TC-Cht acts by adsorption on the steel surface and exhibits mixed type behavior with predominantly cathodic nature. The adsorption of TC-Cht molecules on the surface of stainless steel followed the Langmuir isotherm. The TC-Cht showed a high inhibition efficiency of >94% at 500 mg L?1 concentration. Surface investigation using SEM and EDX supported the inhibitor adsorption on the steel surface. 相似文献
18.
19.
20.