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61.
Mazen Hamoui Ahmed Larbi Sébastien Bommart Patrick Fauré Arnaud Largey Francois Canovas 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2010,20(1):59-65
Rare cases of pseudoaneurysm of the profunda femoris artery following hip fractures have been described in the literature.
Awareness of this complication and a high level of suspicion allow early diagnosis and treatment, and thereby reduce the morbidity
of this condition. We present a case of a false aneurysm of a perforating branch of the profunda femoris artery following
osteosynthesis of an intertrochanteric fracture, which was treated successfully by coil embolisation. 相似文献
62.
Nawaf Al-Mutairi MD FRCP Mazen Alshiltawy MSc Mohamed El Khalawany MD Arun Joshi MD Bayoumy Ibrahim Eassa MD Yashpal Manchanda MD DNB Samir Gomaa MSc Ibrahim Darwish MSc Manish Rijhwani MD 《International journal of dermatology》2009,48(8):862-869
Background Cutaneous leishmaniasis (CL) is a major public health problem. The currently available therapies are expensive, not freely available, toxic, and not always curative. A simple, effective, noninvasive therapeutic approach is required for the treatment of CL.
Aims To determine the clinical patterns of CL and to report our experience in the management of CL.
Methods One hundred and ten patients with CL seen between January 2005 and December 2007 were included in this study. The diagnosis was based on clinical features, parasitologic diagnosis, histopathology, and culture. Each patient was treated according to disease severity with either topical (cryotherapy or imiquimod) or systemic (itraconazole or dapsone) monotherapy, or a combination of these modalities.
Results CL was more common in adult expatriate men, with the upper limbs as the most commonly affected site. Noduloulcerative CL was the most common presentation (84.6%). Atypical CL was found in 18 patients. Skin biopsy was the most common diagnostic technique (66.6%). Monotherapy showed an overall success rate of 56.41%, whereas combination therapy was successful in 69.56% of cases. Cryotherapy alone was successful in 68.18% of cases. Imiquimod alone was ineffective.
Conclusion A stepwise approach represents a rational and practical way of confirming CL. A combination of itraconazole/dapsone and topically applied imiquimod is safe, simple, and effective for the treatment of CL. More studies are needed to establish the role of such an approach. Cryotherapy is also safe, simple and effective for the treatment of CL. 相似文献
Aims To determine the clinical patterns of CL and to report our experience in the management of CL.
Methods One hundred and ten patients with CL seen between January 2005 and December 2007 were included in this study. The diagnosis was based on clinical features, parasitologic diagnosis, histopathology, and culture. Each patient was treated according to disease severity with either topical (cryotherapy or imiquimod) or systemic (itraconazole or dapsone) monotherapy, or a combination of these modalities.
Results CL was more common in adult expatriate men, with the upper limbs as the most commonly affected site. Noduloulcerative CL was the most common presentation (84.6%). Atypical CL was found in 18 patients. Skin biopsy was the most common diagnostic technique (66.6%). Monotherapy showed an overall success rate of 56.41%, whereas combination therapy was successful in 69.56% of cases. Cryotherapy alone was successful in 68.18% of cases. Imiquimod alone was ineffective.
Conclusion A stepwise approach represents a rational and practical way of confirming CL. A combination of itraconazole/dapsone and topically applied imiquimod is safe, simple, and effective for the treatment of CL. More studies are needed to establish the role of such an approach. Cryotherapy is also safe, simple and effective for the treatment of CL. 相似文献
63.
Kanagarajan K Ganesh S Alakhras M Go ES Recco RA Zaman MM 《Southern medical journal》2003,96(6):600-601
Evidence of West Nile encephalitis virus infection has been documented in most states of the continental United States within a short period of its first introduction in 1999. Health care providers are mostly aware of the usual presentations of this disease, eg, aseptic meningitis, encephalitis and Guillain-Barré syndrome. We present a patient whose only manifestations were cerebellar ataxia and fever. 相似文献
64.
Christina Bergqvist Bilal Abdallah Divina‐Justina Hasbani Ossama Abbas Abdul Ghani Kibbi Lamiaa Hamie Mazen Kurban Nelly Rubeiz 《American journal of medical genetics. Part A》2018,176(3):733-738
65.
Amifampridine phosphate (Firdapse®) is effective and safe in a phase 3 clinical trial in LEMS
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Shin J Oh MD Natalya Shcherbakova MD Anna Kostera‐Pruszczyk MD PhD Mohammad Alsharabati MD Mazen Dimachkie MD Jose Munoz Blanco MD Thomas Brannagan MD Dragana Lavrnić MD PhD Perry B Shieh MD PhD Christophe Vial MD Andreas Meisel MD Samuel Komoly MD PhD DSc Benedikt Schoser MD Kumaraswamy Sivakumar MD Yuen So MD PhD LEMS Study Group 《Muscle & nerve》2016,53(5):717-725
66.
Saad Althuwaini Fahad Bamehriz Abdullah Aldohayan Waleed Alshammari Saleh Alhaidar Mazen Alotaibi Abdullah Alanazi Hossam Alsahabi Majid Abdularahman Almadi 《Obesity surgery》2018,28(4):916-922
Background and Aims
Laparoscopic sleeve gastrectomy (LSG) might be associated with a new onset or worsening of gastroesophageal reflux disease (GERD). We aim to evaluate the prevalence of post-LSG GERD symptoms and its predictors.Methods
We included patients who underwent primary LSG at a university hospital from 2009 to 2015. We used the GERD-Health-Related Quality of Life (GERD-HRQL) questionnaire and included questions regarding regurgitation to evaluate symptoms before and after LSG; each item was scored from 1 to 5 based on the symptom severity.Results
A total of 213 patients (mean age, 36.08 ± 10.22 years; 48.36% were men) were included. The mean preoperative body mass index (BMI) was 47.84 kg/m2, mean percent total weight loss was 37.99% (95% CI, 36.64 to 39.34), mean percent excess weight loss was 84.14% (95% CI, 80.91 to 87.36), and the mean percent excess BMI loss was 84.17% (95% CI, 80.94 to 87.41). The mean heartburn score while standing increased (0.71 vs. 1.09, p < 0.01) as well as the score of heartburn requiring a diet change (0.67 vs. 1.16, p < 0.01) post-LSG. The scores for dysphagia, odynophagia, and regurgitation increased. New-onset heartburn was reported in 47.06% of our cohort. Those with high preoperative BMIs were less likely to develop new-onset or worsening symptoms of GERD (odds ratio [OR], 0.97; 95% confidence interval [CI], 0.95–0.99). More severe heartburn symptoms while standing were associated with higher risks of developing or worsening GERD symptoms (OR, 1.22; 95% CI, 1.01–1.47). None of the other variables could predict the development or worsening of the GERD symptoms.Conclusion
Symptoms of heartburn and regurgitation are common after LSG; however, none of the variables preoperatively could strongly predict patients who would develop new onset or experience worsening of symptoms postoperatively.67.
BACKGROUND/AIMS: Alcohol use and hepatitis C are prominent risk factors for liver injury and this review offers the current understanding of each factor's effects on liver disease. METHODS: A Medline database search was preformed for English articles with a focus on alcohol, hepatitis C and liver disease. Article citations were also considered for further applicable articles, and the strongest studies were included in our review. RESULTS: Up to 60% of patients with hepatitis C have a past history of alcohol use. In patients with hepatitis C, chronic alcohol consumption of more than 5 drinks/day increases the rate of liver fibrosis, risk for cirrhosis, hepatocellular carcinoma, and, possibly, death from liver disease. Numerous studies have further found that even moderate amounts of alcohol can be detrimental to hepatitis C patients. The prevalence of hepatitis C is higher in alcoholics with advanced liver disease than in alcoholics without liver disease. Also, recent alcohol use decreases the response rate to interferon treatment. CONCLUSIONS: Hepatitis C and alcohol use are often co-occurring risk factors for liver disease, and though their interaction is not clear, it is known that heavy drinking significantly promotes liver disease progression. 相似文献
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70.
Congenital leptin deficiency is a rare recessive genetic disorder resulting in severe hyperphagia and early onset obesity. It is caused by mutations in the LEP gene encoding leptin. To date, only two mutations have been identified in the LEP gene, Δ133G and R105W. We present the third reported mutation identified in an Egyptian patient with very low serum leptin levels and severe early onset obesity (BMI = 51). Direct sequencing of the coding region of the LEP gene revealed a novel homozygous missense mutation, N103K. The N103K mutation was not found in 100 alleles from 50 unrelated Egyptian normal-weight control subjects using polymerase chain reaction and restriction fragment length polymorphism analysis. In conclusion, this study presents the third reported mutation of the LEP gene and will provide further insight into the physiologic role of leptin in human obesity. 相似文献