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排序方式: 共有238条查询结果,搜索用时 15 毫秒
81.
中药复方治疗黄体功能不全致不孕症170例 总被引:8,自引:0,他引:8
0 引言黄体功能不全(LPD)是造成不孕的重要原因之一,约有10%~40%不孕症和反复流产与之有关[1]. 1993/2003我们在临床上以中药复方治疗LPD所致不孕症,疗效满意. 相似文献
82.
体液中29种中枢神经系统药物的高效毛细管电泳系统分析方法 总被引:7,自引:0,他引:7
建立了高效毛细管电泳系统分析法,分析体液样品中29种CNS药物,作为CNS药物中毒的快速的初筛方法。血、尿样品用有机溶剂萃取,胃液直接进样。用酸、弱碱和中性3组缓冲液体系进行电泳分离。以组分与电渗流迁移时间之比的相对迁移时间和紫外吸收光谱为定性指标。最低检测浓度0.5~5μg·mL-1。在此法基础上可增加分析品种。通用的提取方法可避免漏检,广谱分离条件便于分类,专一分离条件便于定性。本法用于实际中毒样品分析,证实所建方法操作简便、分析时间短、杂质干扰小。 相似文献
83.
84.
Martens FM; van der Vleuten CP; Grol RP; op 't Root JM; Crebolder HF; Rethans JJ 《Family practice》1997,14(2):153-159
OBJECTIVES: The main aim of this study was to reach consensus between
students, faculty and general practice teachers on the educational
objectives and requirements of the clerkship in general practice. METHOD:
The consensus procedure consisted of four steps and all active general
practice teachers (n = 116) were asked to participate in the study.
RESULTS: We identified 189 educational objectives: 127 complaints
(problems, symptoms, syndromes), 29 clinical skills and 37 objectives
concerning the theoretical dimensions of general practice. Educational
requirements crystallized to 16 essential preconditions of a teaching
practice and 35 didactic activities to be performed by the general practice
teachers. CONCLUSIONS: These consensus results will be used to structure
the medical curriculum and as guidelines for the educational process during
the clerkship.
相似文献
85.
Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection
ML Everard A Swarbrick M Wrightham J McIntyre C Dunkley PD James HF Sewell AD Milner 《Archives of disease in childhood》1994,71(5):428-432
To study the cellular infiltrate that occurs within the airways of infants with respiratory syncytial virus bronchiolitis, samples of airways secretions were obtained by bronchial lavage from the lower respiratory tract of infants ventilated for this condition and from the upper airway of non-intubated infants with this disorder using nasopharyngeal aspirates. Cytospin samples were prepared so that differential cell counts could be performed on the cells obtained and alkaline phosphatase-antialkaline phosphatase immunocytochemical analysis of lymphocyte subsets was carried out using a panel of monoclonal antibodies, which included anti-CD3, anti-CD4, anti-CD8, anti-CD19, and anti-TcR gamma delta. Results from the lower and upper airways were similar. Large numbers of inflammatory cells were obtained, of which neutrophils accounted for a median of 93% in the upper airway and 76% in the lower airway. The numbers of CD8 positive cells detected were small and consistently less than CD4 positive cells, median CD4:CD8 ratios being 22.5:1 and 15:1 for the lower and upper airways. CD19 positive cells were rarely observed and no gamma delta positive lymphocytes were detected. These results indicate that neutrophils probably play a major part in causing symptoms in these infants. They do not support the concept that excessive lymphocyte mediated cytotoxic activity is principally responsible for the pathology in respiratory syncytial virus bronchiolitis. 相似文献
86.
87.
Differential binding of erythroid and myeloid progenitors to fibroblasts and fibronectin 总被引:11,自引:2,他引:9
Using a novel coverslip-transfer culture technique, we recently demonstrated that primitive erythroid burst-forming units (BFU-E) can migrate, proliferate, and differentiate in intimate association with stromal fibroblastoid cells in the presence of serum proteins and erythropoietin. No other exogenous hemopoietic growth factors are required. Most of the colonies that develop in this system are very large erythroid bursts, and very few granulocyte-macrophage (GM) colonies are observed. In this report, we present data indicating that the predominance of erythroid burst colonies in this culture system is due to preferential binding of primitive erythroid progenitors to the stromal fibroblastoid cells and not to differential stimulation of these erythroid progenitors by these cells. We next show that the binding of BFU-E to stromal cells is blocked by anti-fibronectin antibodies. Finally, we demonstrate the preferential binding of BFU-E to fibronectin by using glass coverslips or Petri dishes coated with purified human plasma fibronectin. The binding is blocked by a monoclonal antibody specific for the cell-binding domain of fibronectin. We conclude that: primitive erythroid progenitors bind strongly whereas G and/or M progenitors (CFU-G/M) bind only weakly to fibronectin; primitive erythroid progenitors bind to the cell-binding domain on the fibronectin molecule; and erythroid progenitors and precursors remain bound to fibronectin throughout differentiation. 相似文献
88.
Parenchymal cysts of the lower neck 总被引:4,自引:0,他引:4
Som PM; Sacher M; Lanzieri CF; Solodnik P; Cohen BA; Reede DL; Bergeron RT; Biller HF 《Radiology》1985,157(2):399-406
We report on the appearance of parathyroid, thyroid, and cervical thymic cysts on computed tomography (CT) scans. The differential diagnostic considerations include thyroglossal and branchial cleft cysts, cystic hygromas, primary and metastatic tumors, dermoids, teratomas, choristomas, tracheoesophageal and cervical bronchogenic cysts, as well as cystic neuromas, abscesses, and lipomas. Most cannot be differentiated using CT alone and require clinical observations, laboratory testing, and surgical and histologic findings for definitive diagnosis. Our experience with these rare lesions is reported, and the differential diagnoses are discussed. 相似文献
89.
Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene 总被引:2,自引:0,他引:2
Ishikawa-Brush Y; Powell JF; Bolton P; Miller AP; Francis F; Willard HF; Lehrach H; Monaco AP 《Human molecular genetics》1997,6(8):1241-1250
An X;8 translocation was identified in a 27-year-old female patient
manifesting multiple exostoses and autism accompanied by mental retardation
and epilepsy. Through molecular analysis using yeast artificial chromosomes
(YACs) and cosmid clones, the translocation breakpoint was isolated and
confirmed to be reciprocal within a 5'-GGCA- 3' sequence found on both X
and 8 chromosomes without gain or loss of a single nucleotide. The
translocation breakpoint on the X chromosome occurred in the first intron
of the gastrin-releasing peptide receptor (GRPR) gene and that on
chromosome 8 occurred approximately 30 kb distal to the 3' end of the
Syndecan-2 gene (SDC2), also known as human heparan sulfate proteoglycan or
fibroglycan. The GRPR gene was shown to escape X-inactivation. A dosage
effect of the GRPR and a position effect of the SDC2 gene may, however,
contribute the phenotype observed in this patient since the orientation of
these genes with respect to the translocation was incompatible with the
formation of a fusion gene. Investigation of mutations in these two genes
in unrelated patients with either autism or multiple exostoses as well as
linkage and association studies is needed to validate them as candidate
genes.
相似文献
90.
It is recognized that in a study of the behaviour of these
serological reactions in rcsponse to treatment, it is important to cop.-
sider the types of disease, the duration of infection, the amount of
treatment, the kind or drug or drugs used. the scheme of individual
dosage, the intcrval of doses, the concomitant usc of two drugs ancl
the duration of trcatmcnt. Hmvever, the purpose of this paper is
concerned primarily with the early serological reactions in response to
treatment with special reference to the types of disease, the duration
of infection and the amount of treatment. 相似文献