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排序方式: 共有356条查询结果,搜索用时 62 毫秒
71.
Mandeep Singh MRCSEd Jovina LS See FRCSEd Maria C Aquino MD Lennard SY Thean FRCSEd Paul TK Chew FRCSEd 《Clinical & experimental ophthalmology》2009,37(4):345-351
Background: The aim of this work was to image trabeculectomy blebs using spectral domain optical coherence tomography (SDOCT).
Methods: In this prospective cross-sectional study, patients who had undergone trabeculectomy with at least 3 months of follow up were included. Blebs were imaged using an adapted SDOCT system (Cirrus HD-OCT, Carl Zeiss Meditec Inc., Dublin, CA, USA) and time domain anterior segment optical coherence tomography (ASOCT) (Visante OCT, Carl Zeiss Meditec Inc.). An observer masked to clinical data assessed the utility of SDOCT and ASOCT in visualizing structures in successful and failed blebs.
Results: Fifty-one eyes were imaged, of which 43 (84.3%) were successful. SDOCT showed wall thickening (93.0% vs. 67.4%, P = 0.006) and discrete hyporeflective spaces in the wall (88.4% vs. 14.0%, P < 0.0001) in a greater proportion of successful blebs than ASOCT. SDOCT showed the bleb cavity (23.3% vs. 48.8%, P = 0.02), scleral flap (34.9% vs. 90.7%, P < 0.0001), subflap space (20.9% vs . 72.1%, P < 0.0001) and ostium (9.3% vs. 88.4%, P < 0.0001) in fewer successful blebs than ASOCT. The internal ostium was not visualized in any failed bleb using SDOCT, whereas ASOCT showed the ostium in 87.5% of failed blebs ( P = 0.001). SDOCT showed cystic spaces in the bleb wall in a greater proportion of successful blebs than failed blebs (88.4% vs. 37.5%, P = 0.005).
Conclusions: SDOCT imaging was able to show fine superficial features in the bleb wall. However, SDOCT had limited clinical utility in that it did not provide useful information about deep features such as flap position, bleb cavity formation or patency of the subflap space and internal ostium. 相似文献
Methods: In this prospective cross-sectional study, patients who had undergone trabeculectomy with at least 3 months of follow up were included. Blebs were imaged using an adapted SDOCT system (Cirrus HD-OCT, Carl Zeiss Meditec Inc., Dublin, CA, USA) and time domain anterior segment optical coherence tomography (ASOCT) (Visante OCT, Carl Zeiss Meditec Inc.). An observer masked to clinical data assessed the utility of SDOCT and ASOCT in visualizing structures in successful and failed blebs.
Results: Fifty-one eyes were imaged, of which 43 (84.3%) were successful. SDOCT showed wall thickening (93.0% vs. 67.4%, P = 0.006) and discrete hyporeflective spaces in the wall (88.4% vs. 14.0%, P < 0.0001) in a greater proportion of successful blebs than ASOCT. SDOCT showed the bleb cavity (23.3% vs. 48.8%, P = 0.02), scleral flap (34.9% vs. 90.7%, P < 0.0001), subflap space (20.9% vs . 72.1%, P < 0.0001) and ostium (9.3% vs. 88.4%, P < 0.0001) in fewer successful blebs than ASOCT. The internal ostium was not visualized in any failed bleb using SDOCT, whereas ASOCT showed the ostium in 87.5% of failed blebs ( P = 0.001). SDOCT showed cystic spaces in the bleb wall in a greater proportion of successful blebs than failed blebs (88.4% vs. 37.5%, P = 0.005).
Conclusions: SDOCT imaging was able to show fine superficial features in the bleb wall. However, SDOCT had limited clinical utility in that it did not provide useful information about deep features such as flap position, bleb cavity formation or patency of the subflap space and internal ostium. 相似文献
72.
贺国丽 《国外医学:妇产科学分册》2009,(2):147-147
根据沙利度胺和拓扑特肯的活性机制和具抗血管生成的特性,本研究比较了沙利度胺联合拓扑特肯与拓扑特肯单用在复发的上皮性卵巢、输卵管、腹膜癌的疗效。
此项历时4年的多中心的前瞻性随机2期研究得到明尼苏达大学妇女癌症中心的协助。人选者具有下列条件之一:①在以铂类和紫杉醇为基础的初始化疗后未控。 相似文献
73.
敏定偶用于35岁以上妇女的疗效、安全性和周期控制 总被引:11,自引:0,他引:11
<正> 口服避孕药在投放市场之初,应用于各种年龄段的妇女。然而资料显示早期使用的高剂量口服避孕药会增加心肌梗塞的发病率;在1975年,美国食品药物管理局(FDA)不建议40岁以上的妇女服用避孕药,对30岁以上的吸烟妇女建议她们要么停止吸烟要么改换避孕方式。随着研究的进一步深入及低剂量口服避孕药的问市,已证实任何年龄的非吸烟 相似文献
74.
Enio R Vasques Estela RR Figueira Joel A Rocha-Filho Cinthia Lanchotte Jorge LS Ximenes Helena B Nader Ivarne LS Tersariol Marcelo A Lima Tiago Rodrigues José EM Cunha Eleazar Chaib Luiz AC D'Albuquerque Flávio HF Galv?o 《Hepatobiliary & pancreatic diseases international : HBPD INT》2022,21(2):190-192
<正>To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan failure.Intracellular calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (TD),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca2+,showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1], 相似文献
75.
76.
Cost-effectiveness of blood transfusion and white cell reduction in elective colorectal surgery 总被引:3,自引:0,他引:3
BACKGROUND: The use of white cell (WBC)-reduced blood in elective colorectal surgery appears to reduce the frequency of postoperative infection. The question to be addressed is whether the cost:benefit ratio justifies the recommendation that WBC-reduced blood should be used for all colorectal surgery. STUDY DESIGN AND METHODS: Patients admitted for elective colorectal surgery (n = 197) were randomly assigned to receive transfusion consisting of whole blood or WBC- reduced whole blood. Postoperative complications, postoperative stay, and hospital charges were compared. RESULTS: Forty-eight patients received WBC-reduced whole blood, 56 received unfiltered whole blood, and 93 received no transfusion. Postoperative infections were significantly higher (p < 0.001) in the group that received unfiltered whole blood. That group also had longer hospital stays: 17 days as compared to stays of 10 and 11 days for the group receiving no transfusion and the group receiving filtered whole blood transfusions, respectively (p < 0.01). The total hospital cost per patient receiving unfiltered whole blood was $12,347, as compared to $7,867 for those who received WBC-reduced whole blood and $7,030 for those who received no transfusion. CONCLUSION: The use of WBC-reduced whole blood transfusions in elective colorectal surgery significantly reduces the frequency of postoperative infection, the length of hospital stay, and the total hospital charges for patients needing blood transfusion. 相似文献
77.
78.
Krimer LS; Hyde TM; Herman MM; Saunders RC 《Cerebral cortex (New York, N.Y. : 1991)》1997,7(8):722-731
The entorhinal cortex (ERC) has been implicated in the pathophysiology of
Alzheimer's disease, schizophrenia and other disorders affecting cognitive
functions. While powerful anatomical and histochemical methods
(immunohistochemistry, in situ hybridization, etc.) may be applied
(although with limitations) to postmortem human brain, each analysis should
utilize a cytoarchitectonic approach to provide appropriate comparisons
within the subdivisions of the ERC. Accordingly, we describe here the
normal cyto- and myeloarchitecture of the human ERC as a prerequisite for
the accompanying study of this region in schizophrenia. Our parcellation of
this cortex differs from previous treatments in three ways. First, we
adopted specific criteria of inclusion to define each subdivision of the
region. Although distinctive ERC features are most prominent in the
intermediate portion of this region, at least one of these features was
considered the minimum necessary criterion to include adjacent tissue in
the entorhinal area. Second, we used morphometric measurements (neuronal
size and density as well as subdivisional volume and laminar thickness) to
support our qualitative evaluation. Third, we have applied to the human ERC
the conventional cytoarchitectonic nomenclature of the entorhinal cortex
used previously in studies of non-human primates. This allows a more
accurate extrapolation of the available numerous experimental anatomical,
physiological and psychological data on this region to the human. As in the
monkey, the five main subareas were recognized in the human (prorhinal,
lateral, intermediate, sulcal and medial) but three required further
subdivision (intermediate, sulcal and medial). The morphometric results
obtained suggested a progression of the human entorhinal cortex from the
peripheral to the central subareas, with the intermediate subarea (281) as
the most complete entorhinal subdivision. Compared with non-human primates,
the human ERC not only retains the basic periallocortical organization but
also demonstrates further evolution. Taken together with available
experimental data on the connectivity of this brain region, these results
provide an anatomical basis for evaluating the ERC in human behavior.
相似文献
79.
Colin T Walsh Yong Wei M Guillaume Wientjes Jessie LS Au 《Journal of translational medicine》2008,6(1):4
Background
The role of basic fibroblast growth factor (bFGF) in chemoresistance is controversial; some studies showed a relationship between higher bFGF level and chemoresistance while other studies showed the opposite finding. The goal of the present study was to quantify bFGF levels in archived tumor tissues, and to determine its relationship with chemosensitivity. 相似文献80.
硝基甘油对狗缺血区冠脉循环的作用 总被引:1,自引:0,他引:1
用实验性犬冠脉狭窄模型,冠脉内恒流灌注硝基甘油0.5μg/kg.min-1,使冠脉血流量(CBF)增加、远端小动脉压(DCP)、冠脉血管总阻力(RT)、小冠脉血管阻力(RS)及冠状静脉低切血粘(ηb)减少;而主动脉压和心率无明显变化。恒流灌注硝基甘油1μg/kg.min-1时,在开始5min内冠脉循环的变化同上,并伴大冠脉血管阻力(RL)减少,10 min后出现CBF减少和RT,RL及ηb增加。结果提示,硝基甘油有缓解和加重心肌缺血的双重作用,其作用可能与剂量张扩张远端小动脉压的程度有关。 相似文献