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41.
42.
Mathijs?VogelzangEmail author Felix?Zijlstra Maarten?WN?Nijsten 《BMC medical informatics and decision making》2005,5(1):38
Background
Tight glucose control by intensive insulin therapy has become a key part of critical care and is an important field of study in acute coronary care. A balance has to be found between frequency of measurements and the risk of hypoglycemia. Current nurse-driven protocols are paper-based and, therefore, rely on simple rules. For safety and efficiency a computer decision support system that employs complex logic may be superior to paper protocols. 相似文献43.
Testicular tumors: prospective analysis of real-time US patterns and abdominal staging 总被引:3,自引:0,他引:3
Echomorphologic features of 57 testicular lesions (48 neoplasms, nine benign lesions) were analyzed prospectively by means of high-resolution real-time ultrasonography (US). There was a broad spectrum of texture patterns for testicular malignancies, 92% of which exhibited a predominantly decreased echogenicity compared with that of normal tissue. US findings alone could not be used to make a specific prediction of malignant disease or to classify a neoplasm histologically. However, different kinds of tumors exhibited characteristic echomorphologic features that corresponded to their gross morphologic appearance; a knowledge of these echomorphologic features is extremely useful for the US differentiation of tumors from nonneoplastic scrotal pathologic conditions. All neoplasms in this series displayed distinct abnormalities in parenchymal texture, and all were detected with US. The sensitivity and predictive value of a normal sonogram were as high as 100%. With regard to the detection of retroperitoneal lymph node metastases from testicular tumors, abdominal US had an overall accuracy rate of 96% and was of superior diagnostic value compared with bipedal lymphangiography. 相似文献
44.
45.
Campbell JK; Houser OW; Stevens JC; Wahner HW; Baker HL Jr; Folger WN 《Radiology》1978,126(3):695-702
One hundred forty-one patients with cerebral or cerebellar infarction were examined by computed tomography (CT) as soon after the ictus as possible. The examination was repeated in 7 days, and a radionuclide brain scan was performed. The overall detection rate for ischemic infarction was approximately equal for both techniques, ranging from 58% for radionuclide scanning to 66% for the delayed CT. Almost half of the supratentorial infarcts examined by CT on the day of the ictus were demonstrated. Mass effect was observed as early as the first day and as late as the 25th day. 相似文献
46.
47.
Comenzo RL Sanchorawala V Fisher C Akpek G Farhat M Cerda S Berk JL Dember LM Falk R Finn K Skinner M Vosburgh E 《British journal of haematology》1999,104(3):553-559
AL amyloidosis patients ineligible for dose-intensive melphalan (200 mg/m2) were enrolled on a phase 11 trial to be treated with two cycles of intermediate-dose melphalan (IDM 100 mg/m2) and mobilized blood stem cells (BSC). For mobilization patients were randomized to either GM-CSF 250 microg/m2 for 3 d followed by G-CSF 10 microg/ kg for 3 d (GM+G), or G-CSF 10 microg/kg for 6 d (G-alone), with leukaphereses on days 5, 6 and 7. To minimize morbidity, we planned to support each cycle with 3 5 x 106 CD34+ cells/kg and had a collection target of 7 x 10(6) CD34+ cells/kg. Those who did not achieve the target were treated with one cycle of IDM. 30 patients, a median of 62 years old and 7 months from diagnosis, were enrolled. Both mobilization regimens were generally well tolerated, and similar in terms of CD34+ cells and CFU-GM collected, but only 6/28 patients achieved the collection target (GM+G four, G-alone two). Despite a 19% incidence of grade 4 toxicities, IDM therapy was well tolerated. At a median follow-up of 24 months (19-36) 57% of patients had survived, 17% with durable complete haematological responses and 40% with improved or stable amyloid organ involvement, including 3/9 patients with predominant cardiac amyloid who are alive 2-3 years after treatment. The 100 d mortality was 20%. In conclusion, no definitive differences were identified between the mobilization regimens and IDM was an active regimen in AL for selected patients. 相似文献
48.
Gestational trophoblastic disease metastatic to the brain 总被引:2,自引:0,他引:2
49.
Uterine carcinoma in mice treated neonatally with tamoxifen 总被引:11,自引:6,他引:5
The induction of preneoplastic and neoplastic lesions by the widely used
antiestrogen Tamoxifen was studied in female mice. Outbred CD-1 mice were
treated with Tamoxifen (1, 2, 5, 10, 25 or 50 microg/pup/day) for the first
5 days after birth. At 14-17 months, reproductive tract tissues were
examined for pathological changes. In the ovary, corpora lutea were lacking
while cysts were quite common in Tamoxifen-exposed mice at all doses;
cystadenomas were seen in two mice. Structural malformations and epithelial
hyperplasia of the oviduct were seen in 100% of the treated mice.
Malformations of the uterus, cervix, and vagina were also seen. Excessive
vaginal keratinization was not a common feature although vaginal adenosis
was observed more often after Tamoxifen treatment than previously reported
after similar treatment with diethylstilbestrol (DES). The most striking
histological features, however, were seen in the uterus. One hundred
percent of the Tamoxifen- treated mice at all doses exhibited uterine
hypoplasia with focal areas of basal cell hyperplasia in the lining
endometrium. Progressive cellular atypias were seen in the lining
endometrium ranging from atypical hyperplasia to uterine adenocarcinoma;
the highest incidence of uterine adenocarcinoma was 7/14 (50%) observed in
the Tamoxifen 10 microg/pup/day dose group. No similar tumors were observed
in corresponding control mice. The induction of atypical uterine
hyperplasia and adenocarcinoma combined with other abnormalities observed
in genital tract structure following neonatal treatment with Tamoxifen
suggests the developing reproductive tract is exquisitely sensitive to
perturbation by compounds with hormonal activity. These studies provide the
basis for future investigation into the mechanisms of Tamoxifen's
carcinogenic effects in experimental animals, and to the risk benefit
analysis for the prophylactic use of Tamoxifen in healthy women who are at
risk of developing breast cancer.
相似文献
50.
1-{2-[(取代苯基)甲氧基]-2-(取代苯基)乙基}-1H-三唑和苯并三唑类化合物的合成及抗真菌活性 总被引:1,自引:0,他引:1
报道了39个新的1-{2-[(取代苯基)甲氧基]-2-(取代苯基)乙基}-1H-三唑和苯并三唑类化合物的合成与体外抑菌试验,结果表明,化合物6,13的抗真菌活性为益康唑的4~10倍,化合物10,12,14,15,20,22,23,28.30和31等对大部分真菌活性也优于或相当于益康唑及克霉唑,化合物23和31抗裴氏着色菌活性为益康唑、克霉唑的30倍以上,化合物22抗白念珠菌活性为益康唑的8倍,克霉唑的4倍。 相似文献