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991.
Delphine Girlich Laurent PoirelPatrice Nordmann 《Diagnostic microbiology and infectious disease》2013
The recently developed SUPERCARBA medium was evaluated together with 2 commercially available selective culture media containing carbapenems: CHROMagar KPC (CHROMagar) and Brilliance CRE (Oxoid, Thermofisher Scientific). A total of 142 enterobacterial isolates were tested, including 131 isolates with reduced susceptibility to carbapenems. The SUPERCARBA medium has the highest sensitivity (96.5%) (detecting virtually all carbapenemase producers including OXA-48–like producers) as compared to Brilliance CRE (76.3%) and CHROMagar KPC (43%). The specificity of the screening media was similar, ranging from 57% to 68%. 相似文献
992.
Marie-Justine Guerquin Benjamin Charvet Geoffroy Nourissat Emmanuelle Havis Olivier Ronsin Marie-Ange Bonnin Mathilde Ruggiu Isabel Olivera-Martinez Nicolas Robert Yinhui Lu Karl E. Kadler Tristan Baumberger Levon Doursounian Francis Berenbaum Delphine Duprez 《The Journal of clinical investigation》2013,123(8):3564-3576
993.
994.
Bouaziz JD Ortonne N Giustiniani J Schiavon V Huet D Bagot M Bensussan A 《The Journal of investigative dermatology》2005,125(6):1273-1278
Patients with advanced cutaneous T cell lymphoma (CTCL) exhibit profound defects in cell-mediated immunity. Although it has been suggested that Sezary syndrome (SS) patients have a decreased natural killer (NK) lymphocyte activity, nothing has been reported concerning the sensitivity of Sezary cells to NK lymphocyte-mediated cytotoxicity. Peripheral blood NK cells from healthy donors were tested against Sezary tumoral cell lines as well as against freshly isolated Sezary cells. Further, we studied their ability to exhibit antibody -dependent cell-mediated cytotoxicity using either the murine anti-CD158k/KIR3DL2 monoclonal antibody (moAb) AZ158 that specifically recognizes Sezary cells, or the anti-CD52 monoclonal antibody alemtuzumab. The results show that Sezary cell lines are susceptible to NK lymphocyte lysis. More importantly, we found that freshly isolated malignant cells are killed either by IL-2 activated allogeneic NK lymphocytes or when the tumor lymphocyte targets are incubated with an anti-MHC class I F(ab)'2 antibody. Further, anti-KIR3DL2 and anti-CD52 moAb can enhance the NK lysis. Finally, we report that NK lymphocytes isolated from SS patients are potentially cytotoxic lymphocytes against autologous malignant Sezary cells. These findings indicate that antitumor-mediated NK lymphocyte cytotoxic activity can be triggered in patients with CTCL and raise the possibility of developing novel therapeutic strategies by stimulating their innate immunity. 相似文献
995.
996.
Paolo Martelletti Zaza Katsarava Christian Lampl Delphine Magis Lars Bendtsen Andrea Negro Michael Bj?rn Russell Dimos-Dimitrios D Mitsikostas Rigmor H?jland Jensen 《The journal of headache and pain》2014,15(1):47
The debate on the clinical definition of refractory Chronic Migraine (rCM) is still far to be concluded. The importance to create a clinical framing of these rCM patients resides in the complete disability they show, in the high risk of serious adverse events from acute and preventative drugs and in the uncontrolled application of therapeutic techniques not yet validated.The European Headache Federation Expert Group on rCM presents hereby the updated definition criteria for this harmful subset of headache disorders. This attempt wants to be the first impulse towards the correct identification of these patients, the correct application of innovative therapeutic techniques and lastly aim to be acknowledged as clinical entity in the next definitive version of the International Classification of Headache Disorders 3 (ICHD-3 beta). 相似文献
997.
Gisèle Pickering MD Bruno Pereira PhD Florentin Clère MD Marc Sorel MD Geraldine de Montgazon MD Malou Navez MD Pascale Picard MD Delphine Roux MSc Véronique Morel MSc Rachida Salimani MSc Mireille Adda MSc Valérie Legout MD Claude Dubray MD 《Pain practice》2014,14(1):E1-E7
Background and aims
Neuropathic pain has been shown to be accompanied by cognitive impairment, but the specific impact of postherpetic neuropathic pain on cognitive processes has not been explored. This study aims to evaluate the impact of pain on several domains of cognition in older patients with postherpetic neuralgia (PHN).Methods
This cross‐sectional study ( clinicaltrial.gov NCT 00989040) included 84 individuals after signature of informed consent. Participants: 42 patients with PHN and 42 healthy volunteers. Of the 42 PHN patients, 21 received systemic treatment (antidepressants, anticonvulsants, opiates) and 21 had topical treatment with the 5% lidocaine medicated plaster. All participants performed a panel of four cognitive tests: reaction time, semantic memory, decision‐making, and visual memory (Cantab®, Cambridge).Results
Forty men and 44 women with a mean age of 72 ± 8 years participated. Each PHN patient was matched by age and gender with a healthy volunteer. Vigilance, decision‐making, and semantic memory were significantly impaired (P < 0.05) in patients on systemic treatment, especially with antidepressants, while no significant changes were noted between the lidocaine plaster group and their matched controls of healthy volunteers.Conclusion
This study shows the deleterious effect of systemic PHN treatment on several domains of cognition. Cognitive impairment associated with pain and antidepressants may be reversed by topical pain management. Topical treatment with 5% lidocaine medicated plaster is a valuable alternative for pain alleviation and maintains cognitive integrity in this vulnerable population. 相似文献998.
The HIV-1 Tat protein is able to raise a humoral immune response in the absence of adjuvant. Here, we investigated whether this property can be transferred to unrelated antigens. We first observed that Tat self-adjuvanticity is a T cell-dependent phenomenon in which a Th2 profile predominates. Then, we showed that the determinant governing the property is located in the region 1-57 of Tat and that fragment Tat1-57 can make two unrelated model antigens immunogenic in the absence of adjuvant. We found a Th2 pattern of immune response for both antigens, suggesting that Tat1-57 mediates this response. Next, we showed that, although less efficient than Tat1-57, the Tat37-57 fragment suffices to transfer the adjuvant property to other antigens. We also observed that preservation of cysteine 37 is absolutely required for the transfer, suggesting the role of disulphide-mediated dimerization in the transfer of the adjuvant property. Our observations suggest that for various antigens, the use of Tat37-57 or Tat1-57 or Tat22-57C(22-34)A might represent an alternative to adjuvants in humans, thereby opening up new perspectives in vaccination. 相似文献
999.
Desjardins Clément Larrieu-Ciron Delphine Choquet Sylvain Mokhtari Karima Charlotte Frédéric Nichelli Lucia Mathon Bertrand Ahle Guido Le Garff-Tavernier Magali Morales-Martinez Andrea Dehais Caroline Hoang-Xuan Khê Houillier Caroline 《Journal of neuro-oncology》2022,159(1):151-161
Journal of Neuro-Oncology - Mucosae-associated lymphoid tissue (MALT) lymphomas are a rare and poorly understood form of primary central nervous system lymphoma (PCNSL). The aim of this study was... 相似文献
1000.
Alice Masurel‐Paulet Amélie Piton Sophie Chancenotte Claire Redin Christel Thauvin‐Robinet Yvan Henrenger Delphine Minot Audrey Creppy Marie Ruffier‐Bourdet Julien Thevenon Paul Kuentz Daphné Lehalle Aurore Curie Gaelle Blanchard Ezzat Ghosn Marlene Bonnet Mélanie Archimbaud‐Devilliers Frédéric Huet Odile Perret Nicole Philip Jean‐Louis Mandel Laurence Faivre 《American journal of medical genetics. Part A》2016,170(8):2103-2110