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Delphine Renolleau-Courtois Aurore Lamouroux-Delay Stéphane Delpierre Monique Badier Françoise Lagier-Tessonnier Alain Palot 《The Journal of asthma》2014,51(5):552-558
Objective: We assessed retrospectively the feasibility of a home-based respiratory rehabilitation (RR) program for asthmatics under optimal pharmacological treatment, as this type of care can reduce costs and offer a more patient-friendly approach for subjects with persistent asthma. Methods: Fifty-two patients with persistent asthma were recruited to the RR program (20 males, 32 females, 54?±?11 (SD) years, forced expiratory volume in one second 71?±?33% of predicted mean value, BMI 29.9?±?7.9?kg/m2). This two-month protocol comprised education sessions, respiratory physiotherapy and an exercise training program at home and in groups supervised by an adapted physical activity instructor. Results: Thirty-nine patients completed the whole RR program, i.e. 25% dropout. The dropout rate was significantly higher with respect to younger patients in employment. The number of exacerbations decreased significantly during the year following the program, regardless of whether the patients had dropped out (p?0.02) or not (p?0.001). The distance walked during a 6-min walking test increased by 33?m (p?0.001). Several indices measured during a cycle ergometer test increased significantly after RR: peak oxygen uptake (10%), oxygen uptake at ventilatory threshold (12%) and maximum load (19%), all at a similar maximum heart rate. Concerning quality of life assessment, the Short-Form-36 Item Health Survey revealed a non-significant improvement in the “health change” item after RR (p?0.07). Conclusions: This study demonstrates the potential of a home-based program in the treatment and rehabilitation of patients with asthma. Both functional and physiologic indices improved during the follow-up period. 相似文献
103.
Elena Palma Antonio Riva Christophe Moreno Gemma Odena Satvinder Mudan Nikolai Manyakin Rosa Miquel Delphine Degré Eric Trepo Pau Sancho-Bru Jose Altamirano Juan Caballeria Ane Zamalloa Krishna Menon Nigel Heaton Roger Williams Ramon Bataller Shilpa Chokshi 《Alcoholism, clinical and experimental research》2020,44(4):856-865
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Joshua Elliott Delphine Deryng Christoph Müller Katja Frieler Markus Konzmann Dieter Gerten Michael Glotter Martina Fl?rke Yoshihide Wada Neil Best Stephanie Eisner Balázs M. Fekete Christian Folberth Ian Foster Simon N. Gosling Ingjerd Haddeland Nikolay Khabarov Fulco Ludwig Yoshimitsu Masaki Stefan Olin Cynthia Rosenzweig Alex C. Ruane Yusuke Satoh Erwin Schmid Tobias Stacke Qiuhong Tang Dominik Wisser 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(9):3239-3244
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108.
Sex and Ontogenetic Variation in the Crest of Numida meleagris: Implications for Crested Vertebrates
Delphine Angst Jonathan Barnoud Raphaël Cornette Anusuya Chinsamy 《Anatomical record (Hoboken, N.J. : 2007)》2020,303(4):1018-1034
Crested vertebrates are known from a wide variety of modern and fossil taxa, however, the actual formation and function of the crest is still debatable. Among modern birds, the globally distributed guinea fowl (Numida meleagris) is characterized by having a cranial bony crest (overlain by keratin), but surprisingly little is known about its development. Here, we studied the crest of 202 wild guinea fowl from the same population, using anatomical measurements as well as 2D-morphometry. Our results show that juveniles have smaller skulls than adults and have smaller, simpler crests that are visible even in very young individuals. Among adults, female skulls are smaller than males, and they have smaller, simpler shaped crests, which permit a discrimination between the sexes of 93% when the keratin is preserved with the bony crest, and of 89% when only the bony crest is available. By extrapolation, these results confirm that the crest can be used as an ontogenetic character, as well as for sex discrimination in the fossil record. Our results also show that the overlying keratin does not always mimic the underlying bony crest, which should be considered when reconstructing extinct crested vertebrates. Anat Rec, 303:1018–1034, 2020. © 2019 American Association for Anatomy 相似文献
109.
Pulmonary endothelium as a site of synthesis and storage of interleukin-6 in experimental congestive heart failure 总被引:3,自引:0,他引:3
Gaertner R Lepailleur-Enouf D Gonzalez W Nicoletti A Mandet C Philippe M Mercadier JJ Michel JB 《European journal of heart failure》2003,5(4):435-442
BACKGROUND: Pulmonary endothelium is an early upstream hemodynamic target of left ventricular dysfunction. Interleukin 6 (IL-6) is a pro-inflammatory cytokine reported to increase in congestive heart failure (CHF) patients. AIMS: We sought to determine the origin of IL-6, IL-6 receptor (IL-6R) and gp130 in experimental CHF. METHODS: We used rats with coronary artery ligation as an experimental model of either compensated or decompensated heart failure. Lung and aorta samples were analysed by RT-PCR, ELISA and immunohistochemistry for IL-6 and its receptors. RESULTS: IL-6 mRNA expression increased in the lung of rats with decompensated heart failure and was positively correlated with infarct severity whereas IL-6R mRNA decreased in the lung of myocardial infarction rats and gp130 mRNA remained unchanged. In contrast, there were no changes in IL-6 mRNA expression in the aorta and left ventricular myocardium. IL-6 peptide content as determined by ELISA and Western Blot in lung tissue was 2-fold higher in decompensated heart failure as compared to control rats. These data were confirmed by immunohistochemistry showing a preferential endothelial localization of IL-6 in the CHF lung. IL-6 peptide was also present in the pleural effusion of decompensated heart failure and was positively correlated with IL-6 mRNA expression in the lungs of decompensated HF rats. Pulmonary IL-6 overexpression was associated with nuclear translocation of NF-kappaB and cytosolic degradation of IkappaB. CONCLUSION: Dysfunctional pulmonary endothelium is a source of synthesis and storage of IL-6 in an experimental model of CHF. 相似文献