全文获取类型
收费全文 | 2122篇 |
免费 | 156篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 97篇 |
妇产科学 | 117篇 |
基础医学 | 233篇 |
口腔科学 | 15篇 |
临床医学 | 348篇 |
内科学 | 391篇 |
皮肤病学 | 34篇 |
神经病学 | 211篇 |
特种医学 | 41篇 |
外科学 | 228篇 |
综合类 | 44篇 |
一般理论 | 4篇 |
预防医学 | 250篇 |
眼科学 | 9篇 |
药学 | 144篇 |
肿瘤学 | 116篇 |
出版年
2023年 | 24篇 |
2022年 | 21篇 |
2021年 | 42篇 |
2020年 | 38篇 |
2019年 | 67篇 |
2018年 | 71篇 |
2017年 | 52篇 |
2016年 | 61篇 |
2015年 | 54篇 |
2014年 | 86篇 |
2013年 | 95篇 |
2012年 | 191篇 |
2011年 | 191篇 |
2010年 | 98篇 |
2009年 | 66篇 |
2008年 | 122篇 |
2007年 | 133篇 |
2006年 | 111篇 |
2005年 | 127篇 |
2004年 | 110篇 |
2003年 | 117篇 |
2002年 | 93篇 |
2001年 | 21篇 |
2000年 | 25篇 |
1999年 | 36篇 |
1998年 | 25篇 |
1997年 | 14篇 |
1996年 | 13篇 |
1995年 | 19篇 |
1994年 | 12篇 |
1993年 | 12篇 |
1992年 | 11篇 |
1991年 | 12篇 |
1990年 | 10篇 |
1989年 | 9篇 |
1988年 | 9篇 |
1987年 | 16篇 |
1985年 | 6篇 |
1983年 | 3篇 |
1982年 | 9篇 |
1981年 | 3篇 |
1978年 | 4篇 |
1976年 | 6篇 |
1974年 | 4篇 |
1973年 | 3篇 |
1971年 | 4篇 |
1968年 | 2篇 |
1966年 | 3篇 |
1965年 | 3篇 |
1964年 | 3篇 |
排序方式: 共有2288条查询结果,搜索用时 0 毫秒
71.
Extracorporeal Life Support Bridge to Ventricular Assist Device: The Double Bridge Strategy 下载免费PDF全文
Silvana F. Marasco Casey Lo Deirdre Murphy Robyn Summerhayes Margaret Quayle Adam Zimmet Michael Bailey 《Artificial organs》2016,40(1):100-106
In patients requiring left ventricular assist device (LVAD) support, it can be difficult to ascertain suitability for long‐term mechanical support with LVAD and eventual transplantation. LVAD implantation in a shocked patient is associated with increased morbidity and mortality. Interest is growing in the utilization of extracorporeal life support (ECLS) as a bridge‐to‐bridge support for these critically unwell patients. Here, we reviewed our experience with ECLS double bridging. We hypothesized that ECLS double bridging would stabilize end‐organ dysfunction and reduce ventricular assist device (VAD) implant perioperative mortality. We conducted a retrospective review of prospectively collected data for 58 consecutive patients implanted with a continuous‐flow LVAD between January 2010 and December 2013 at The Alfred Hospital, Melbourne, Victoria, Australia. Twenty‐three patients required ECLS support pre‐LVAD while 35 patients underwent LVAD implantation without an ECLS bridge. Preoperative morbidity in the ECLS bridge group was reflected by increased postoperative intensive care duration, blood loss, blood product use, and postoperative renal failure, but without negative impact upon survival when compared with the no ECLS group. ECLS stabilization improved end‐organ function pre‐VAD implant with significant improvements in hepatic and renal dysfunction. This series demonstrates that the use of ECLS bridge to VAD stabilizes end‐organ dysfunction and reduces VAD implant perioperative mortality from that traditionally reported in these “crash and burn” patients. 相似文献
72.
Kaur A Sanford HB Garry D Lang S Klumpp SA Watanabe D Bronson RT Lifson JD Rosati M Pavlakis GN Felber BK Knipe DM Desrosiers RC 《Virology》2007,357(2):199-214
The immunogenicity and protective capacity of replication-defective herpes simplex virus (HSV) vector-based vaccines were examined in rhesus macaques. Three macaques were inoculated with recombinant HSV vectors expressing Gag, Env, and a Tat-Rev-Nef fusion protein of simian immunodeficiency virus (SIV). Three other macaques were primed with recombinant DNA vectors expressing Gag, Env, and a Pol-Tat-Nef-Vif fusion protein prior to boosting with the HSV vectors. Robust anti-Gag and anti-Env cellular responses were detected in all six macaques. Following intravenous challenge with wild-type, cloned SIV239, peak and 12-week plasma viremia levels were significantly lower in vaccinated compared to control macaques. Plasma SIV RNA in vaccinated macaques was inversely correlated with anti-Rev ELISPOT responses on the day of challenge (P value<0.05), anti-Tat ELISPOT responses at 2 weeks post challenge (P value <0.05) and peak neutralizing antibody titers pre-challenge (P value 0.06). These findings support continued study of recombinant herpesviruses as a vaccine approach for AIDS. 相似文献
73.
OBJECTIVE: To examine factors that influence teachers' perceptions of and responses to chronic pain in students. METHODS: Two-hundred and sixty classroom teachers responded to a vignette describing a student with limb pain. The 2 x 2 x 2 factorial design included conditions that varied by (a) the presence or absence of documented organic evidence for the pain, (b) cooperative vs. confrontational parent-teacher interactions, and (c) the presence or absence of communication from the medical team. Teachers rated pain severity and impairment, relief from classroom responsibilities, extent of accommodations the student would require in school, and sympathy for the student and family. RESULTS: Documented medical evidence supporting the pain was the most influential factor affecting teachers' responses to pain. Parental attitude also influenced responses. Communication from the medical team influenced teachers' decisions about relief from responsibilities but did not affect other reactions. CONCLUSIONS: Teachers' responses to students with pain are influenced by situational factors. Efforts to increase school functioning in youth with chronic pain should incorporate attempts to help teachers respond to pain adaptively. 相似文献
74.
75.
76.
Linda Stein Gold James Q. Del Rosso Leon Kircik Neal D. Bhatia Deirdre Hooper Walter Nahm Iain Stuart 《The Journal of clinical and aesthetic dermatology》2020,13(11):44
BACKGROUND: Efficacy and safety of FMX103 1.5% for papulopustular rosacea were previously demonstrated in two 12-week, Phase 3 studies. OBJECTIVE: We sought to evaluate the safety and efficacy of FMX103 1.5% foam for up to 52 weeks of treatment. METHODS: Following the completion of two 12-week, double-blind, vehicle-controlled, Phase 3 studies, subjects were invited to enter a 40-week open-label extension study in which all subjects applied FMX103 1.5% once daily. Efficacy endpoints were the reduction in inflammatory lesions and the rate of IGA treatment success from the double-blind baseline. Safety assessments included adverse events, vital signs, laboratory tests, and facial tolerability signs and symptoms. RESULTS: The favorable safety profile of FMX103 1.5% observed in the double-blind studies was maintained over extended treatment lasting up to one year. There were no serious treatment-related adverse events. Long-term treatment with FMX103 1.5% was associated with a greater than 82-percent reduction in inflammatory lesions from baseline and with over 79 percent of subjects achieving treatment success. At the end of the open-label treatment period, over 82 percent of subjects indicated they were overall “satisfied” or “very satisfied” with FMX103 1.5%. All facial local tolerability symptoms improved through Week 52. LIMITATIONS: Due to the nature of the open-label study, lacking a vehicle-treated control, no statistical comparisons can be made. CONCLUSION: FMX103 1.5% demonstrated a favorable safety and tolerability profile for up to 52 weeks. Long-term efficacy was demonstrated by progressive reductions in inflammatory lesions and increasing IGA treatment success, suggesting that FMX103 1.5% may be a suitable option for the treatment for papulopustular rosacea. 相似文献
77.
A 59-year-old female with metacarpal joint locking is presented. The successful closed manipulation is described with a review of the literature. 相似文献
78.
79.
There are approximately 6 million individuals with a diagnosis of mental retardation in the United States. Because of deinstitutionalization of patients with mental retardation, coupled with an increase in their life expectancy, emergency physicians are increasingly encountering and managing patients with mental retardation in the emergency department. Many emergency physicians are uncomfortable when interacting with individuals with mental retardation, which often carries over to the assessment and management of these patients in the ED. The purpose of this review is to aid the emergency physician in understanding the patient with mental retardation, their comorbid conditions, and the approach to evaluating and managing these patients in the ED. 相似文献
80.
Søgaard KK Cronin-Fenton DP Pedersen L Sørensen HT Lash TL 《Inflammatory bowel diseases》2008,14(4):519-525
BACKGROUND: Incidences of inflammatory bowel disease (IBD) and of breast cancer have increased over the last decades. The influence of IBD on breast cancer prognosis, however, is unknown. We therefore examined the impact of IBD on treatment receipt and survival in breast cancer patients. METHODS: Information on breast cancer patients (stage and treatment) diagnosed between 1980 and 2004 was sourced from the Danish Cancer Registry. Data on IBD and potential confounders were extracted from the Danish National Registry of Patients covering all Danish hospitals. Cox regression was used to compute mortality rate ratios (MRRs) among breast cancer patients with IBD, compared to their non-IBD counterparts, adjusting for age, stage, comorbidity measured by the Charlson Index, and calendar year. RESULTS: We identified 71,148 breast cancer cases; 67 also had Crohn's disease (CD) and 216 had ulcerative colitis (UC). Patients with CD had more advanced stage and received radiotherapy less, and chemotherapy more, frequently than patients without IBD. In the adjusted analyses there was no substantial survival difference in breast cancer patients with and without IBD (MRR(CD) = 1.22; 95% confidence interval [CI] = 0.85-1.75; MRR(UC) = 1.09; 95% CI = 0.86-1.38). In a stratified analysis, chemotherapy was associated with poorer survival in patients with CD (MRR(CD) = 1.93; 95% CI = 1.00-3.72). CONCLUSIONS: Breast cancer patients with UC receive the same treatment and have similar survival to breast cancer without IBD. In contrast, breast cancer patients with CD are treated with radiotherapy less often. Survival of breast cancer in patients with CD treated with chemotherapy is poorer compared to survival in patients without IBD. 相似文献