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121.
Discoid lupus erythematosus is a manifestation of chronic cutaneous lupus erythematosus with a small risk of systemic involvement. In this review article, the role of predisposing factors such as haplotype, hormones, antibodies and sunlight are discussed. The clinical features, including variants and associations, and management options are presented. 相似文献
122.
Extensive nodular cutaneous amyloidosis: an unusual presentation 总被引:2,自引:0,他引:2
PR Criado†‡ CS Silva† C Vasconcellos†‡ NYS Valente† JB Maito† 《Journal of the European Academy of Dermatology and Venereology》2005,19(4):481-483
Amyloidosis is characterized by the deposition of a group of unrelated proteins leading to changes in tissue architecture and function. The nodular variant is the rarest form of the cutaneous amyloidoses. We report a patient with localized nodular amyloidosis without systemic amyloid involvement or paraproteinaemia after 6 years of follow-up. The unusual aspects of our case were a plaque presentation rather than nodular, and the disseminated pattern observed. 相似文献
123.
124.
双波长薄层扫描法测定痛得安胶囊中新乌头碱的含量 总被引:3,自引:0,他引:3
目的:建立痛得安胶囊中新乌头碱的含量测定方法。方法:采用双波长薄层扫描法,以正己烷-乙酸乙酯-无水乙醇-氨水(12:8:2.5:0.5)为展开剂,碘化饿钾试液为显色剂,测定该制剂中新乌头碱的含量。结果:线性范围为1~6ug。平均回收率为94.80%,RSD为2.03%。结论:本法操作简便。结果可靠。实用,适合该制剂中新乌头碱的含量测定。 相似文献
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128.
Clinical application of human egg cryopreservation 总被引:20,自引:17,他引:3
Tucker MJ; Morton PC; Wright G; Sweitzer CL; Massey JB 《Human reproduction (Oxford, England)》1998,13(11):3156-3159
Clinical egg cryopreservation has been applied during a 4-year period with
some limited success. Mostly mature and a few immature eggs were frozen
slowly and thawed rapidly in 1,2-propanediol and sucrose, and subsequently
inseminated by intracytoplasmic sperm injection (ICSI). Three studies were
performed in which: (i) it was established that 55% of aged unfertilized
mature eggs survive freezing; (ii) in 22 cycles of thawed donated eggs
cryosurvival was 24% with 15 cycles reaching transfer, and five pregnancies
were initiated, one of which went to term at 39 weeks with fraternal twin
boys, and one remains ongoing at 37 weeks; and (iii) in five cycles, where
in-vitro fertilization patients had some of their own eggs frozen/ thawed,
cryosurvival of mature eggs was poor at only 2.2%, although 44% sibling
germinal vesicle (GV) stage eggs survived. A normal female infant delivered
at 40 weeks arose from transfer of two embryos where GV eggs underwent in-
vitro maturation post-thaw and were fertilized by ICSI. Pregnancies
reported here and by others indicate a burgeoning awareness of the
potential benefits of egg cryopreservation, prompting cautious optimism for
the future of this technology.
相似文献
129.
Walter JB; Brander C; Mammen M; Garboczi DN; Kalams SA; Whitesides GM; Walker BD; Eisen HN 《International immunology》1997,9(3):451-459
HLA-A2 heavy chain and beta 2-microglobulin were expressed in Escherichia
coli, and refolded in the presence of peptides derived from HIV-1 RT and
gag proteins. When recombinant HLA-A2 molecules were attached to cells
lacking HLA-A2, the cells became susceptible to lysis by HLA-A2-restricted
cytotoxic T lymphocyte (CTL) clones specific for peptides derived from RT
and gag proteins. Limiting dilution analyses of peripheral blood
mononuclear cells from HIV-1-infected individuals showed that the
recombinant HLA-A2 peptide complexes covalently immobilized on microspheres
stimulated the development of HLA-A2 peptide-specific CTL. Preformed
HLA-peptide complexes may provide an alternative to immunization procedures
that depend upon intracellular processing of antigen to elicit T cell
responses.
相似文献
130.
Doppman JL; Dedrick RL; Shook DR; Lutz RJ; Goldstein SR; Blacklock JB; Boretos JW; Paul RH; Austin HA d; Bowman RL 《Radiology》1986,159(2):477-483
Techniques have been developed for isolated perfusion of chemotherapeutic agents in patients with glioblastoma. Three catheters that facilitate crossing the carotid siphon have been developed; two are based on an everting or toposcopic principle, and one uses microjets for deflectability and improved mixing. Blood from the ipsilateral jugular vein is aspirated at high volumes (300 ml/min) for extracorporeal circulation through an adsorption column (for recovery of carmustine) or dialysers (for recovery of cisplatin). Preliminary experience in 10 patients suggests that high doses of chemotherapeutic agent can be administered using these catheters, with reduced retinal and systemic toxicity. 相似文献