收费全文 | 251480篇 |
免费 | 18421篇 |
国内免费 | 1128篇 |
耳鼻咽喉 | 2788篇 |
儿科学 | 6520篇 |
妇产科学 | 4597篇 |
基础医学 | 32997篇 |
口腔科学 | 4560篇 |
临床医学 | 25308篇 |
内科学 | 53576篇 |
皮肤病学 | 3389篇 |
神经病学 | 24270篇 |
特种医学 | 8394篇 |
外国民族医学 | 11篇 |
外科学 | 38515篇 |
综合类 | 3468篇 |
一般理论 | 318篇 |
预防医学 | 21352篇 |
眼科学 | 6553篇 |
药学 | 17008篇 |
5篇 | |
中国医学 | 363篇 |
肿瘤学 | 17037篇 |
2023年 | 1212篇 |
2022年 | 2021篇 |
2021年 | 5444篇 |
2020年 | 3268篇 |
2019年 | 5314篇 |
2018年 | 5964篇 |
2017年 | 4481篇 |
2016年 | 4967篇 |
2015年 | 5842篇 |
2014年 | 8619篇 |
2013年 | 11818篇 |
2012年 | 18041篇 |
2011年 | 18934篇 |
2010年 | 10594篇 |
2009年 | 9449篇 |
2008年 | 16624篇 |
2007年 | 17482篇 |
2006年 | 17320篇 |
2005年 | 17302篇 |
2004年 | 16207篇 |
2003年 | 15062篇 |
2002年 | 14069篇 |
2001年 | 2122篇 |
2000年 | 1614篇 |
1999年 | 2331篇 |
1998年 | 3067篇 |
1997年 | 2568篇 |
1996年 | 2188篇 |
1995年 | 2097篇 |
1994年 | 1751篇 |
1993年 | 1574篇 |
1992年 | 1269篇 |
1991年 | 1160篇 |
1990年 | 1008篇 |
1989年 | 980篇 |
1988年 | 978篇 |
1987年 | 957篇 |
1986年 | 955篇 |
1985年 | 972篇 |
1984年 | 1225篇 |
1983年 | 1128篇 |
1982年 | 1367篇 |
1981年 | 1315篇 |
1980年 | 1149篇 |
1979年 | 712篇 |
1978年 | 748篇 |
1977年 | 636篇 |
1976年 | 587篇 |
1975年 | 470篇 |
1974年 | 475篇 |
Methods: A retrospective cohort design and data from two US healthcare claims repositories were employed. The study population included patients who had non-metastatic cancer of the breast, colon/rectum, lung or ovaries, or non-Hodgkin’s lymphoma (NHL), and who received myelosuppressive chemotherapy regimens with an intermediate/high risk for FN. For each patient, the first cycle of the first course was characterized in terms of PP-CSF use and FN episodes. Crude incidence proportions for PP-CSF and FN during the first cycle were estimated by calendar quarter (2010–2016); multivariable logistic regression models were used to estimate quarter-specific adjusted mean probabilities of FN by PP-CSF use.
Results: The study population totaled 142,730 patients with breast cancer (61%), colorectal cancer (14%), NHL (11%), ovarian cancer (10%) or lung cancer (5%). PP-CSF use increased from 52% in 1Q2010 to 58% in 4Q2016; pegfilgrastim was the most commonly used agent (>96% across quarters). PP-CSF administration on the same day as chemotherapy ranged from 8 to 11% until 1Q2015, and increased to 64% by 4Q2016. Adjusted incidence proportions for FN in the first chemotherapy cycle ranged from 2.7% (95% CI: 2.3–3.0) to 3.7% (95% CI: 3.1–4.3) among those who did not receive PP-CSF, and was 2.6% (95% CI: 2.5–2.7) across quarters among those who received PP-CSF.
Conclusions: Although the use of PP-CSF is commonplace in current US clinical practice, underutilization in cancer patients receiving chemotherapy regimens with an intermediate/high risk for FN may still be an issue. Use of same-day PP-CSF increased markedly from the end of 2015, although this finding reflects (at least in part) increased uptake of pegfilgrastim delivered via an on-body injector as well as the recent change in clinical practice guidelines. Overall, patients receiving PP-CSF appear to have a lower risk of FN during the first cycle of chemotherapy. 相似文献