全文获取类型
收费全文 | 98262篇 |
免费 | 6666篇 |
国内免费 | 514篇 |
专业分类
耳鼻咽喉 | 1242篇 |
儿科学 | 2323篇 |
妇产科学 | 1398篇 |
基础医学 | 12624篇 |
口腔科学 | 2356篇 |
临床医学 | 9698篇 |
内科学 | 21686篇 |
皮肤病学 | 1538篇 |
神经病学 | 9302篇 |
特种医学 | 4015篇 |
外国民族医学 | 1篇 |
外科学 | 16300篇 |
综合类 | 847篇 |
一般理论 | 194篇 |
预防医学 | 6600篇 |
眼科学 | 1848篇 |
药学 | 5921篇 |
中国医学 | 142篇 |
肿瘤学 | 7407篇 |
出版年
2023年 | 879篇 |
2022年 | 1530篇 |
2021年 | 3333篇 |
2020年 | 1845篇 |
2019年 | 2850篇 |
2018年 | 3356篇 |
2017年 | 2376篇 |
2016年 | 2568篇 |
2015年 | 2886篇 |
2014年 | 4000篇 |
2013年 | 5091篇 |
2012年 | 7723篇 |
2011年 | 7830篇 |
2010年 | 4320篇 |
2009年 | 3745篇 |
2008年 | 6444篇 |
2007年 | 6239篇 |
2006年 | 6044篇 |
2005年 | 5950篇 |
2004年 | 5349篇 |
2003年 | 4903篇 |
2002年 | 4405篇 |
2001年 | 655篇 |
2000年 | 516篇 |
1999年 | 726篇 |
1998年 | 905篇 |
1997年 | 715篇 |
1996年 | 578篇 |
1995年 | 572篇 |
1994年 | 458篇 |
1993年 | 467篇 |
1992年 | 379篇 |
1991年 | 336篇 |
1990年 | 309篇 |
1989年 | 297篇 |
1988年 | 306篇 |
1987年 | 275篇 |
1986年 | 303篇 |
1985年 | 293篇 |
1984年 | 370篇 |
1983年 | 320篇 |
1982年 | 343篇 |
1981年 | 343篇 |
1980年 | 267篇 |
1979年 | 159篇 |
1978年 | 198篇 |
1977年 | 184篇 |
1976年 | 137篇 |
1975年 | 138篇 |
1974年 | 139篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
961.
962.
Patrica?Minary-Dohen Pascale?Bailly Xavier?Bertrand Daniel?TalonEmail author 《BMC geriatrics》2003,3(1):5
Background
The risk associated with methicillin-resistant Staphylococcus aureus (MRSA) has been decreasing for several years in intensive care departments, but is now increasing in rehabilitation and chronic-care-facilities (R-CCF). The aim of this study was to use published data and our own experience to discuss the roles of screening for MRSA carriers, the type of isolation to be implemented and the efficiency of chemical decolonization.Discussion
Screening identifies over 90% of patients colonised with MRSA upon admission to R-CCF versus only 50% for intensive care units. Only totally dependent patients acquire MRSA. Thus, strict geographical isolation, as opposed to "social reinsertion", is clearly of no value. However, this should not lead to the abandoning of isolation, which remains essential during the administration of care. The use of chemicals to decolonize the nose and healthy skin appeared to be of some value and the application of this procedure could make technical isolation unnecessary in a non-negligible proportion of cases.Summary
Given the increase in morbidity associated with MRSA observed in numerous hospitals, the emergence of a community-acquired disease associated with these strains and the evolution of glycopeptide-resistant strains, the voluntary application of a strategy combining screening, technical isolation and chemical decolonization in R-CCF appears to be an urgent matter of priority.963.
964.
Erika de Arruda-Chaves Daniel De Conti Thais Tebaldi 《Journal of investigational allergology & clinical immunology》2002,12(2):120-123
BACKGROUND: Nitric oxide is an important regulator of various biological activities in human physiology, and it has been studied in the physiopathology of asthma, especially in exhaled air. OBJECTIVE: We studied the presence of NO in sera of patients with distinct degrees of asthma severity in order to determine a parameter of diagnosis and control of efficacious treatment. METHODS: We determined the presence of NO based upon the Griess reaction in the sera of 124 donors--34 controls and 90 asthmatic subjects. RESULTS: Asthmatic patients presented higher levels of nitric oxide in peripheral blood (56.54 +/- 33.37) compared to the control group (3.06 +/- 4.48). A statistically significant difference (p < 0.0001) between the nitric oxide sera levels from the two groups was demonstrated. CONCLUSION: This study demonstrates that nitric oxide sera levels can be used as an additional inflammatory marker in asthma, especially as an auxiliary diagnostic method in children where NO exhaled air analysis is difficult. 相似文献
965.
Pascal Cohen Christian Pagnoux Alfred Mahr Jean‐Pierre Arène Luc Mouthon Véronique Le Guern Marie‐Hélène André Martine Gayraud David Jayne Daniel Blöckmans Jean‐franÇois Cordier Loïc Guillevin The French Vasculitis Study Group 《Arthritis care & research》2007,57(4):686-693
Objective
To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg‐Strauss syndrome (CSS).Methods
In this prospective multicenter therapeutic trial, 48 patients with CSS with at least 1 poor‐prognosis factor at baseline were treated with glucocorticoids and either 12 or 6 intravenous cyclophosphamide pulses.Results
At 8 years, complete remission rates and severe side effects of therapy were comparable for both groups. The overall difference in relapses was not significant between the 12‐pulse and the 6‐pulse regimens (P = 0.07), but when considering only the number of mild relapses this difference became statistically significant (P < 0.02). Although the total number of inclusions was not reached, the study was stopped prematurely in response to the superiority of the 12‐pulse regimen.Conclusion
We concluded that 12 cyclophosphamide pulses were better able to control severe CSS than a 6‐pulse regimen. The optimal duration of therapy remains to be determined. 相似文献966.
Mathew S Maurer Daniel Burkhoff Linda P Fried John Gottdiener Donald L King Dalane W Kitzman 《Journal of the American College of Cardiology》2007,49(9):972-981
OBJECTIVES: The purpose of this study was to evaluate left ventricular (LV) size and structure in elderly subjects with hypertension (HTN) and heart failure who have a normal ejection fraction (HFNEF) in a large population-based sample. BACKGROUND: The pathophysiology of HFNEF is incompletely understood but is generally attributed to LV diastolic dysfunction with normal or reduced LV diastolic chamber size despite greater than normal filling pressures. METHODS: In the Cardiovascular Health Study (n = 5,888), demographic and clinical characteristics and ventricular structure and function were compared in healthy normal subjects (healthy; n = 499), subjects with HTN but not heart failure (HTN; n = 2,184), and subjects with HTN and HFNEF (HFNEF; n = 167). RESULTS: Subjects with HFNEF were older, more obese, and more often African American than healthy and HTN subjects and had a higher prevalence of diabetes, coronary heart disease, and anemia than HTN subjects. Serum creatinine and cystatin-C were increased in HFNEF subjects. Average LV diastolic dimension was significantly increased in HFNEF subjects (5.2 +/- 0.8 cm) compared with healthy (4.8 +/- 0.6 cm) and HTN (4.9 +/- 0.6 cm) subjects. As a result, average calculated stroke volume (89 +/- 25 ml vs. 78 +/- 20 ml and 80 +/- 20 ml) and cardiac output (6.0 +/- 2.0 l/min vs. 4.8 +/- 1.3 l/min and 5.1 +/- 1.4 l/min) were increased in HFNEF compared with healthy and HTN subjects, respectively. CONCLUSIONS: As a group, HFNEF subjects have increased LV diastolic diameter and increased calculated stroke volume. They also have increased prevalence of multiple comorbidities, including anemia, renal dysfunction, and obesity, that can cause volume overload. These data suggest that extracardiac factors, via volume overload, may contribute to the pathophysiology of HFNEF in the elderly. 相似文献
967.
Wit FW Blanckenberg DH Brinkman K Prins JM van der Ende ME Schneider MM Mulder JW de Wolf F Lange JM;ATHENA Study Group 《AIDS (London, England)》2005,19(3):345-348
We studied the dynamics of CD4 cell counts after the interruption of virologically successful highly active antiretroviral therapy (HAART) in 139 patients. Changes in CD4 cell counts during HAART interruption followed a biphasic pattern: an initial rapid decline during the first month followed by a slow decrease. During 48 weeks of follow-up mean CD4 cell counts remained just above the mean pre-HAART level. This limits the feasibility of structured treatment interruptions for patients with low nadir CD4 cell counts. 相似文献
968.
969.
Alain P. Gobert Olivier Boutaud Mohammad Asim Irene A. Zagol-Ikapitte Alberto G. Delgado Yvonne L. Latour Jordan L. Finley Kshipra Singh Thomas G. Verriere Margaret M. Allaman Daniel P. Barry Kara M. McNamara Johanna C. Sierra Venkataraman Amarnath Mohammed N. Tantawy Diane Bimczok M. Blanca Piazuelo M. Kay Washington Keith T. Wilson 《Gastroenterology》2021,160(4):1256-1268.e9
970.