全文获取类型
收费全文 | 12231篇 |
免费 | 813篇 |
国内免费 | 93篇 |
专业分类
耳鼻咽喉 | 81篇 |
儿科学 | 273篇 |
妇产科学 | 222篇 |
基础医学 | 1448篇 |
口腔科学 | 286篇 |
临床医学 | 865篇 |
内科学 | 3296篇 |
皮肤病学 | 546篇 |
神经病学 | 618篇 |
特种医学 | 526篇 |
外科学 | 2156篇 |
综合类 | 42篇 |
一般理论 | 1篇 |
预防医学 | 283篇 |
眼科学 | 192篇 |
药学 | 733篇 |
中国医学 | 14篇 |
肿瘤学 | 1555篇 |
出版年
2023年 | 157篇 |
2022年 | 328篇 |
2021年 | 504篇 |
2020年 | 272篇 |
2019年 | 357篇 |
2018年 | 453篇 |
2017年 | 415篇 |
2016年 | 454篇 |
2015年 | 418篇 |
2014年 | 539篇 |
2013年 | 558篇 |
2012年 | 880篇 |
2011年 | 929篇 |
2010年 | 472篇 |
2009年 | 389篇 |
2008年 | 658篇 |
2007年 | 740篇 |
2006年 | 651篇 |
2005年 | 614篇 |
2004年 | 527篇 |
2003年 | 440篇 |
2002年 | 402篇 |
2001年 | 187篇 |
2000年 | 190篇 |
1999年 | 172篇 |
1998年 | 93篇 |
1997年 | 57篇 |
1996年 | 64篇 |
1995年 | 38篇 |
1994年 | 44篇 |
1993年 | 44篇 |
1992年 | 114篇 |
1991年 | 104篇 |
1990年 | 98篇 |
1989年 | 128篇 |
1988年 | 90篇 |
1987年 | 82篇 |
1986年 | 61篇 |
1985年 | 62篇 |
1984年 | 43篇 |
1983年 | 33篇 |
1979年 | 21篇 |
1978年 | 28篇 |
1977年 | 22篇 |
1976年 | 14篇 |
1975年 | 15篇 |
1973年 | 18篇 |
1970年 | 20篇 |
1968年 | 14篇 |
1966年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
S Shishido S Baba T Ohigashi J Muraki A Hayashi M Tachibana N Deguchi S Jitsukawa M Hata H Tazaki 《Hinyokika kiyo. Acta urologica Japonica》1990,36(9):997-1001
We report the results and complications of 103 consecutive patients who underwent percutaneous removal of renal and ureteral stones. The overall clinical success rate was 80.6%. For the recent 33 cases in which UL-arm fluoroscopy was used, however, the success rate was as high as 87.9%, which was considered to be due to easier establishment of percutaneous direct access. The most common complications were bleeding (18.5%), extravasation (15.5%) and fever (9.7%). Four cases with significant bleeding required arteriography, but there were no sign of arteriovenous fistula nor pseudoaneurysms in any cases. To study renal parenchymal damage in the percutaneous procedures, plasma renin activities (PRA) were compared in 54 cases after six months. However, significant elevation of PRA did not occur in any case. 相似文献
12.
13.
Hisashi Kai Takahiro Mori Keisuke Tokuda Narimasa Takayama Nobuhiro Tahara Kiyoko Takemiya Hiroshi Kudo Yusuke Sugi Daisuke Fukui Hideo Yasukawa Fumitaka Kuwahara Tsutomu Imaizumi 《Hypertension research》2006,29(9):711-718
Oxidative stress is implicated in the pathogenesis of various cardiovascular diseases. We have shown that in Wistar rats with a suprarenal aortic constriction (AC), pressure overload-induced transient perivascular inflammation (monocyte chemoattractant protein-1 [MCP-1] induction and macrophage accumulation) in the early phase is the determinant of reactive myocardial fibrosis and resultant diastolic dysfunction in the late phase. Thus, we investigated the role of reactive oxygen species production in cardiac remodeling in AC rats. Superoxide production and the footprint of lipid peroxidation were assessed using dihydroethidium staining and immunohistostaining against 4-hydroxy-2-nonenal (4-HNE), respectively. In sham rats, dihydroethidium and 4-HNE signals were scarcely found in the heart. At day 3, AC rats showed dihydroethidium signals mainly in the intramyocardial arterial wall, whereas modest 4-HNE staining was observed diffusely in the myocardium. These signals declined to lower levels by day 14 despite sustained hypertension. Chronic administration of a subdepressor dose of an angiotensin II type 1 receptor blocker candesartan reduced the pressure overload-induced dihydroethidium and 4-HNE signals at day 3. Moreover, candesartan decreased MCP-1 induction and macrophage infiltration at day 3 and prevented myocardial fibrosis at day 14, without affecting left ventricle and myocyte hypertrophy. In conclusion, acute pressure overload induced self-limited superoxide production mainly in the vascular wall. The reactive oxygen species production would contribute to the perivascular inflammation and subsequent myocardial fibrosis. Angiotensin II was suggested to have a pressure-independent effect on the reactive oxygen species production. 相似文献
14.
Yoshifumi Arisaka Daisuke Masuda Takayuki Kii Michiaki Takii Ken‐Ichi Katsu 《Digestive endoscopy》2006,18(Z1):S115-S118
The authors experienced a case of Mirizzi’s syndrome successfully treated with endoscopic nasogallbladder drainage (ENGBD). The patient was a 63‐year‐old man. He was admitted with abdominal pain and jaundice. Laboratory data indicated leukocytosis and elevation of serum bilirubin level. Abdominal ultrasound showed marked swelling of gallbladder and debris in the gallbladder, therefore, the authors strongly suspected Mirizzi’s syndrome. He had past history of acute myocardial infarction and treated with anticoagulation therapy. Then, the authors couldn’t perform surgical removal or percutaneous transhepatic drainage, and tried endoscopic transpapillary drainage. Endoscopic retrograde cholangiopancreatography revealed smooth stricture in the superior portion of common bile duct and occlusion of the cystic duct, and ENGBD was then performed. After ENGBD, his complaints, laboratory data, swelling of gallbladder and stricture of common bile duct were all remarkably improved. 相似文献
15.
16.
Abstract: The effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) and stroma-free hemoglobin (SFH) on vascular responsiveness to various vasoactive substances were examined in isolated perfused rat kidneys. The kidneys isolated from rats were perfused with 6% PHP, 6% SFH, and 6% hydroxyethylstarch (HES) solution at a constant flow rate. Vascular responsiveness to acetylcholine (ACh), nitroglycerin (NG), norepinephrine (NE), and angiotensin-II (ANG-II) was examined by measuring the perfusion pressure (PP). Effects of inhibition of endothelium-derived relaxing factor (EDRF) by NG -monomethyl L-arginine (L-NMMA) on NE-induced and ANG-II-induced renal vascular responses were examined. ACh and NG induced a dose-dependent decrease in perfusion pressure (PP) in all groups. NE and ANG-II induced an increase in PP in all groups, but NE-induced and ANG-II-induced responses in the PHP-perfused and SFH-perfused groups were significantly larger than those in the HES-perfused group. L-NMMA did not alter vascular responsiveness to NE and ANG-II. These results indicate that PHP and SFH do not inhibit EDRF induced by ACh, but hemoglobin moiety per se does augment the vascular responsiveness to NE and ANG-II in the isolated perfused rat kidney. 相似文献
17.
Iwao Fukui Kazunori Kihara Hideaki Sekine Yuichi Tachibana Tsuneo Kawai Daisuke Ishiwata Hiroyuki Oshima 《Cancer chemotherapy and pharmacology》1992,30(Z1):S37-S40
Between November 1986 and April 1989, 101 patients with superficial bladder cancer were treated with intravesical instillations of mitomycin C on day 1 and doxorubicin on day 2 of each week for 5 consecutive weeks. Of 61 complete responders, 23 patients with carcinoma in situ and 28 with papillary cancer were randomly assigned to a non-maintenance group or to a group receiving maintenance therapy consisting of monthly instillations of the same drugs for 12 months. The 2-year non-recurrence rate calculated for patients with carcinoma in situ was significantly better in the maintenance group than in the non-maintenance group. A similar tendency was observed for patients with papillary cancer, although the difference was not significant. Side effects were considerable, with moderate to severe bladder irritation occurring in approximately half of the patients. In addition to our previous findings, the present results indicate that this intravesical combination chemotherapy is effective in eliminating superficial bladder cancers and that since the effect is not durable, even in complete responders, maintenance therapy is necessary to reduce subsequent tumor recurrence.Presented at the 4th International Conference on Treatment of Urinary Tract Tumors with Adriamycin/Farmorubicin, 16–17 November 1990, Osaka, Japan 相似文献
18.
19.
20.
Kazuo Kitagawa Masayasu Matsumoto Keisuke Kuwabara Masafumi Tagaya Toshiho Ohtsuki Ryuji Hata Hirokazu Ueda Nobou Handa Kazufumi Kimura Takenobu Kamada 《Brain research》1991,561(2)
We investigated the effects of mild and non-lethal ischemic insult on neuronal death following subsequent lethal ischemic stress in various brain regions, using a gerbil model of bilateral cerebral ischemia. Single 10-min ischemia consistently caused neuronal damage in the hippocampal CA1, CA2, CA3 and CA4, layer III/IV of the cerebral cortex, dorsolateral part of the caudoputamen and ventrolateral part of the thalamus. On the other hand, in double ischemia groups, 2-min ischemic insult 2 days before 10-min ischemia exhibited significant protection in the CA1 and CA3 of the hippocampus, the cerebral cortex, the caudoputamen and the thalamus. Five-min ischemic insult 2 days before 10-min ischemia also showed protective effect in the same areas as those of 2-min ischemia except for the CA1 region of the hippocampus, while 1-min ischemic insult exhibited no protective effect in any brain regions. In the immunoblot analysis, both 2- and 5-min ischemia caused increased synthesis of heat shock protein 72 (HSP 72) in the hippocampus, but 1-min ischemia did not. The present study demonstrated that the ‘ischemic tolerance’ phenomenon was widely found in the brain and also suggested that ischemic treatment severe enough to cause HSP 72 synthesis might be needed for induction of ‘ischemic tolerance’. 相似文献