ACTIVITY PROFILES OF ANTIMUTAGENS

The short-term tests (STT) that have been usedsuccessfully to identify mutagens and potentialcarcinogens increasingly are being used to identifyantimutagens and potential anticarcinogens.Theconcept of activity profiles,already appliedsuccessfully to the display of mutagenicity data     

咪喹莫特对Bcl-2、ki67、p53及基底细胞癌细胞调亡的影响

背景:咪喹莫特是一种被证明对基底细胞癌(BBC)治疗有效的免疫调节剂,其作用机制尚不明。目的:探索咪喹莫特对一些蛋白因子如Bcl-2、ki67、p53及基底细胞癌调亡的作用。资料和方法:一家大学医院的白种患者30例,患原发性BBCs,肿瘤直径大于8mm,采用随机双盲对照法,进行临床及免疫组化研究。对2001-09/2002-02的30例BBCs患者分2组治疗,其中24例用5%咪喹莫特乳膏,6例用Aldara(美国3M制药公司)赋形剂。于治疗开始前及治疗后第8d、15d分别取标本进行免疫组化研究,用石蜡包埋标本进行Bcl-2、ki67、p53检测,用冰冻切片TUNEL(Terminaldeoxynu-…     

慢性心衰患者24h心率变异性的不同频谱成分与不同的死亡方式相关

目的:评价利用慢性心衰(CHF)患者24hHolter记录分析心率变异性(HRV)是否能提供其死亡方式的信息(泵衰竭vs猝死)。方法和结果:本研究分析了连续330例窦性心律的CHF患者的24hHRV。对24h自动HRV的时域、频域和分形分析所得的指标进行评价,并对临床评价、超声心动图、右心导管插入术、运动试验、血液生化检查及心律失常类型的资料进行分析。对患者随访3年。两个均包含24h频域指标的简易多元模型,分别能够识别进行性泵衰竭和猝死的高危患者。低于0.04Hz[甚低频(VLF)]夜间HRV的功率降低(≤509ms2)、高肺楔压(PWP≥18mmHg)和低左室射血…     

中西医结合治疗缺血性肠炎22例临床分析

缺血性肠炎是由于肠道血液供应不足或回流受阻导致肠壁缺血缺氧损伤所引起的急性或慢性炎症性病变。以腹痛、便血及腹泻为主要临床表现，重者可致全层肠壁受损而出现坏死、穿孔、腹膜炎及感染中毒性休克。     

ANGURAR BLEPHARITIS IN WELL KNOWN CLINJ OF RIBOFLAVIN ARIBOFLAVINOSIS - A CAL . MANIFESTATION DEFICIENCY

Sebrell in 1938 (i)五rst suspected that pellagra might be a manifestation of multiple deficiency in which ribofiavin .might play a role. Experiments carrie.d out by him and Butler in the ''same year showed that diets low in ribofiavin content would produce a clinical syndrome, which we now know to'' be char- acteristic of ribofiaviri. deficiency. The w~rk of these authors w.as later confirmed by workers in all partbs of the world. Spies (2)i Sydenstricker (3), Viakil（二）, Gopalan (5), Hou (6), (7), etc. a:re important contributors. The disease has been reported in tIhe United States of America,''England, Africa, India, M.alaya and is quite common in China, especially among soldiers, students, coolies, refugees and prisoners. .