全文获取类型
收费全文 | 14752篇 |
免费 | 944篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 96篇 |
儿科学 | 512篇 |
妇产科学 | 471篇 |
基础医学 | 1871篇 |
口腔科学 | 218篇 |
临床医学 | 2094篇 |
内科学 | 2652篇 |
皮肤病学 | 276篇 |
神经病学 | 1585篇 |
特种医学 | 301篇 |
外科学 | 1300篇 |
综合类 | 122篇 |
现状与发展 | 1篇 |
一般理论 | 16篇 |
预防医学 | 2027篇 |
眼科学 | 335篇 |
药学 | 948篇 |
中国医学 | 15篇 |
肿瘤学 | 907篇 |
出版年
2023年 | 93篇 |
2022年 | 154篇 |
2021年 | 348篇 |
2020年 | 199篇 |
2019年 | 363篇 |
2018年 | 417篇 |
2017年 | 273篇 |
2016年 | 318篇 |
2015年 | 388篇 |
2014年 | 516篇 |
2013年 | 791篇 |
2012年 | 1103篇 |
2011年 | 1170篇 |
2010年 | 641篇 |
2009年 | 521篇 |
2008年 | 1036篇 |
2007年 | 1045篇 |
2006年 | 1047篇 |
2005年 | 1018篇 |
2004年 | 953篇 |
2003年 | 907篇 |
2002年 | 863篇 |
2001年 | 97篇 |
2000年 | 70篇 |
1999年 | 101篇 |
1998年 | 142篇 |
1997年 | 134篇 |
1996年 | 124篇 |
1995年 | 121篇 |
1994年 | 68篇 |
1993年 | 91篇 |
1992年 | 59篇 |
1991年 | 54篇 |
1990年 | 46篇 |
1989年 | 40篇 |
1988年 | 47篇 |
1987年 | 31篇 |
1986年 | 31篇 |
1985年 | 31篇 |
1984年 | 45篇 |
1983年 | 38篇 |
1982年 | 45篇 |
1981年 | 44篇 |
1980年 | 33篇 |
1979年 | 13篇 |
1978年 | 18篇 |
1977年 | 9篇 |
1976年 | 8篇 |
1973年 | 6篇 |
1972年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
61.
Conway F. Saylor PhD Cynthia Cupit Swenson Ph.D. Paige Powell Ph.D. 《Child psychiatry and human development》1992,22(3):139-149
This article reports highlights from over 200 parents' observations of their preschoolers' play and verbalizations in the year following Hurricane Hugo. Commonly reported activities included reenactment and discussion of the event in multiple mediums, personification of Hugo, and expression of fears related to storms. Precocious concern for others, insight, and vocabulary were also noted. In these intact, relatively high functioning families, parents seemed able to facilitate their youngsters' adjustment without outside intervention.Portions of this report were presented in earlier form at the 1991 Society for Research in Child Development meeting in Seattle, Washington. 相似文献
62.
McNeilly MD Robinson EL Anderson NB Pieper CF Shah A Toth PS Martin P Jackson D Saulter TD White C Kuchibatla M Collado SM Gerin W 《International journal of behavioral medicine》1995,2(4):321-338
It has been speculated that exposure to the chronic stress of racism contributes to the high rates of hypertension among African Americans. Social support may buffer the effects of stress on cardiovascular (CV) health by attenuating stress-induced CV responses that have been linked to hypertension. In this study we investigated the effects of racism and social support on CV reactivity in African American women. Participants showed greater increases in CV and emotional responses while responding and listening to racist provocation. Augmented blood pressure (BP) persisted through recovery following racial stress. Participants receiving no support showed the greatest increases in anger during racist provocation. No significant effects were seen for support on CV reactivity. These results provide some of the first evidence that interactive confrontation with racism elicits significant increases in CV reactivity and emotional distress. Furthermore, individuals receiving less support may be at greater risk for the potentially health-damaging effects of racial stress. These findings may have significant implications for the health of African Americans. 相似文献
63.
Elliott AM Graham JM Curry CJ Pal T Rimoin DL Lachman RS 《American journal of medical genetics》2002,113(4):351-361
Dolichospondylic dysplasia (DD) is a rare skeletal dysplasia primarily characterized by tall vertebral bodies and disproportionate short stature. Radiographic manifestations include tall vertebral bodies and gracile bones of the hands. Patients usually have eye and ear findings in addition to borderline mental retardation; however, tall vertebral bodies and slender tubular bones are also seen in the 3-M syndrome. Patients with the 3-M syndrome have a characteristic face with a triangular shape, frontal bossing, a flattened malar region, full eyebrows, a short nose with a bulbous tip, upturned nares, and full lips. We present two unrelated patients who share a distinct phenotype and have tall vertebral bodies, overtubulation of long bones, and short tubular bones of the hands and feet. We discuss the overlapping and distinguishing features between DD and the 3-M syndrome. Patient 1 was a 13-year-old female, and patient 2 was an unrelated adult female. These patients had normocephaly and short stature. They shared a common phenotype consisting of mild malar hypoplasia, a narrowed nasal body with a fleshy tip, full lips, and normal intelligence. In addition, they showed mild hand and foot abnormalities. These two patients lack many of the typical clinical features of both DD and the 3-M syndrome. They share a common phenotype and likely represent a distinct disorder. The spectrum of disorders with tall vertebral bodies as a key feature may include different entities that may be further defined with the characterization of the molecular defect(s). 相似文献
64.
Effects of tibolone on bone quality in ovariectomized monkeys 总被引:1,自引:0,他引:1
OBJECTIVE: The purpose of this report is to examine the effects of two doses of tibolone on bone quality (bone biomarkers, bone density, and bone strength) in ovariectomized cynomolgus monkeys fed high-fat diets. DESIGN: Ovariectomized cynomolgus monkeys were randomized into one of five treatment groups: placebo-treated control, tibolone (0.2 mg/kg/day), tibolone (0.05 mg/kg/day), conjugated equine estrogens (Premarin, 0.042 mg/kg/day), and conjugated equine estrogens plus medroxyprogesterone acetate (0.042 and 0.167 mg/kg/day, respectively). Bone quality was assessed by determining bone strength and density in vertebrae and femora collected after 24 months of treatment. RESULTS: Monkeys treated for 24 months with tibolone had increased bone mineral density in the distal femur and improved biomechanical properties in the midshaft femur compared with placebo-treated ovariectomized monkeys, as did monkeys treated with conjugated equine estrogens with or without medroxyprogesterone acetate. No treatment effects were seen in lumbar vertebra bone density or strength. There was no significant difference between tibolone and estrogen on biomechanical properties of the femur. CONCLUSION: These data show that tibolone is comparable to conjugated equine estrogens with or without medroxyprogesterone acetate in decreasing bone turnover and increasing bone strength in ovariectomized monkeys. 相似文献
65.
66.
67.
Human chromosome 2 was formed by the head-to-head fusion of two ancestral chromosomes that remained separate in other primates. Sequences that once resided near the ends of the ancestral chromosomes are now interstitially located in 2q13-2q14.1. Portions of these sequences had duplicated to other locations prior to the fusion. Here we present analyses of the genomic structure and evolutionary history of >600 kb surrounding the fusion site and closely related sequences on other human chromosomes. Sequence blocks that closely flank the inverted arrays of degenerate telomere repeats marking the fusion site are duplicated at many, primarily subtelomeric, locations. In addition, large portions of a 168-kb centromere-proximal block are duplicated at 9pter, 9p11.2, and 9q13, with 98%-99% average sequence identity. A 67-kb block on the distal side of the fusion site is highly homologous to sequences at 22qter. A third ~100-kb segment is 96% identical to a region in 2q11.2. By integrating data on the extent and similarity of these paralogous blocks, including the presence of phylogenetically informative repetitive elements, with observations of their chromosomal distribution in nonhuman primates, we infer the order of the duplications that led to their current arrangement. Several of these duplicated blocks may be associated with breakpoints of inversions that occurred during primate evolution and of recurrent chromosome rearrangements in humans. 相似文献
68.
Sharma R Bhatti S Gomez M Clark RM Murray C Ashizawa T Bidichandani SI 《Human molecular genetics》2002,11(18):2175-2187
Friedreich ataxia is commonly caused by large expansions of a GAA triplet-repeat (GAA-TR) sequence in the first intron of the FRDA gene. We used small-pool PCR to analyze somatic variability among 7190 individual FRDA molecules from peripheral blood DNA of subjects carrying 12 different expanded alleles, ranging in size from 241 to 1105 triplets. Expanded alleles showed a length-dependent increase in somatic variability, with mutation loads ranging from 47% to 78%. We noted a strong contraction bias among long alleles (>500 triplets), which showed a 4-fold higher frequency of large contractions versus expansions. Some contractions were very large; of all somatic mutations scored, approximately 5% involved contractions of >50% of the original allele length, and 0.29% involved complete reversion to the normal/premutation length (< or =60 triplets). These observations contrast sharply with the strong expansion bias seen in expanded CTG triplet repeats in myotonic dystrophy. No somatic variability was detected in >6000 individual FRDA molecules analyzed from 15 normal alleles (8-25 triplets). A premutation allele with 44 uninterrupted GAA repeats was found to be unstable, ranging in size from 6 to 113 triplets, thus establishing the threshold for somatic instability between 26 and 44 GAA triplets. Analysis of an additional 7850 FRDA molecules from serially passaged lymphoblastoid cell lines carrying nine expanded alleles (132-933 triplets) showed very low mutation loads, ranging from 0% to 6.2%. Our data indicate that expanded GAA-TR alleles in Friedreich ataxia are highly mutable and have a natural tendency to contract in vivo, and that these properties depend on multiple factors, including DNA sequence, triplet-repeat length and unknown cell-type-specific factors. 相似文献
69.
Narayan P. Verma Cynthia D. Nichols Manfred F. Greiffenstein Rajinder P. Singh Deborah Hurst-Gordon 《Brain topography》1989,1(3):183-191
Summary Thirty subjects (normal controls, patients with putative subcortical dementia and non-demented patient controls) were studied using advanced neurophysiological (16 scalp-electrode positions, computer-assisted brain electrical activity mapping, auditory oddball paradigm) and neuropsychological techniques. Our study suggests that waves earlier than P3 (N1, P2 and N2) are all correlated with global measures of cognitive functions. They are, however, differentially correlated with specific measures of cognitive functions, N1 and P2 with mental speed and N2 with short-term memory. The abnormalities of these waves (earlier than P3) may be an electrophysiologic marker of dementia in patients with putative subcortical states. 相似文献
70.