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排序方式: 共有1213条查询结果,搜索用时 15 毫秒
11.
Steven Mlynarek Morton Corn Charles Blake 《Regulatory toxicology and pharmacology : RTP》1996,23(3):213-224
The exposures of building maintenance personnel and occupants to airborne asbestos fibers, and the effects of operations and maintenance programs on those exposures, continue to be an important public health issue. The subject of this investigation was a large metropolitan county with numerous public buildings which routinely conducted air sampling for asbestos. A total of 302 personal air samples in nine task categories collected during maintenance worker activities in proximity to asbestos-containing materials were analyzed; 102 environmental air samples in four task categories were also analyzed. The arithmetic means of the 8-hr time weighted average exposures for personal sampling for each task category were all below the Occupational Safety and Health Administration permissible exposure level of 0.1 fibers (f)/cc > 5 μm. The highest mean 8-hr time weighted average exposure was 0.030 f/cc > 5 μm for ceiling tile replacement. The maximum asbestos concentration during sample collection for environmental samples was 0.027 f/cc > 5 μm. All asbestos-related maintenance work was done within the framework of an Operations and Maintenance Program (OMP) which utilized both personal protective equipment and controls against fiber release/dispersion. Results are presented in association with specific OMP procedures or controls. These results support the effectiveness of using Operations and Maintenance Programs to manage asbestos in buildings without incurring unacceptable risk to maintenance workers performing maintenance tasks. 相似文献
12.
Functionally active complement proteins C6 and C7 detected in C6- and C7-deficient individuals 总被引:4,自引:2,他引:4
R. WÜRZNER A. ORREN P. POTTER B. P. MORGAN D. PONARD P. SPTH M. BRAI M. SCHULZE L. HAPPE O. G
TZE 《Clinical and experimental immunology》1991,83(3):430-437
Two sensitive sandwich ELISAs based on monoclonal antibodies directed to native C6 and C7 allowed the detection and quantitation of these complement proteins in 20 out of 37 serum samples from individuals who had previously been classified as deficient in these proteins as assessed by immunochemical and/or functional assays. Furthermore, serum from four C6-deficient and one combined C6-/C7-deficient individual showed an increase in the terminal complement complex (TCC) and a decrease in native C6 and C7 after complement activation as assayed by specific ELISAs. Despite their (incomplete) deficiencies, these individuals therefore possess functionally active terminal complement proteins with respect to their ability to generate the TCC. As these individuals have no history of a susceptibility to neisserial infections, even low concentrations of functionally active C6 and C7 may provide sufficient protection against those micro-organisms whose destruction requires TCC formation. 相似文献
13.
Bilateral simultaneous tubal sextuplets: pregnancy after in-vitro fertilization--embryo transfer following salpingectomy 总被引:2,自引:1,他引:2
The presence of a damaged tube has been suggested in recent studies to have
a negative effect on in-vitro fertilization (IVF) outcome. Performing
bilateral salpingectomy prior to IVF to maximize pregnancy rates may also
result in unnecessary surgery. This case is also an example of the
occurrence of interstitial pregnancy after salpingectomy. This unusual type
of ectopic pregnancy must be kept in mind when evaluating a patient
suspected of a possible early abnormal gestation after assisted
reproductive technolologies.
相似文献
14.
15.
P. J. VAN DEN BROEK F. A. M. DEHUE P. C J. LEIJH M. TH. VAN DEN BARSELAAR R. VAN FURTH 《Scandinavian journal of immunology》1982,15(5):467-473
The usefulness of lysostaphin for the removal of cell-adherent and extracellular bacteria in assays performed to measure the intracellular killing of Straphylococcus aureus by granulocytes was investigated. The results showed that the adherence of lysosiaphin to the granulocyte surface is effectuated by a temperature-independent process and that bound lysostaphin is still microbicidal. Lysosiaphin also penetrates into the granulocytes by a temperature dependent process and kills ingested S. aureus intracellularly. Therefore, despite reports to the contrary in the literature, lysosiaphin is not a reliable agent for the removal of only extracellular S. aureus and should no longer be used in assays to determine the rate of intracellular killing by granulocytes. 相似文献
16.
We have an installed base of MAClinical workstations available on hospital wards, which have been used for patient care, education, and research 24 hours a day for the past year. We began with eight machines in the hospital but now have distributed ten more machines to faculty. We have recently increased the programming staff so we can develop more software. The machines and their installation were costly, but have already proven useful for teaching and patient care. Plans for the second and third years of the MAClinical project include workstations for the faculty coordinators of clinical clerkships and expansion of workstations to affiliated hospitals where our students and residents rotate. Software will be expanded to include patient simulations and expert consultations. Medical practice, research, and teaching in the future will need to make more use of information technology. It is not yet clear exactly how and where computers will best serve clinical medicine, but the teaching hospital can be both a laboratory for developing applications and a school for training physicians to use them. 相似文献
17.
Levin JL O'Sullivan MF Corn CJ Williams MG Dodson RF 《Occupational and environmental medicine》1999,56(9):602-605
OBJECTIVES: To present a case of asbestosis and small cell lung cancer caused by asbestos in a clutch refabricator. METHODS: Exposed surfaces of used clutches similar to those refabricated in the worker's workplace were rinsed, and the filtrate analysed by analytical transmission electron microscopy. Tissue samples were also analysed by this technique. RESULTS: Numerous chrysotile fibres of respirable dimensions and sufficient length to form ferruginous bodies (FBs) were detected from rinsed filtrates of the clutch. Bronchoalveolar lavage fluid contained many FBs, characteristic of asbestos bodies. Necropsy lung tissue showed grade 4 asbestosis and a small cell carcinoma in the right pulmonary hilum. Tissue analysis by light and analytical electron microscopy showed tissue burdens of coated and uncoated asbestos fibres greatly exceeding reported environmental concentrations (3810 FBs/g dry weight and 2,080,000 structures > or = 0.5 micron/g dry weight respectively). 72% Of the cores were identified as chrysotile. CONCLUSIONS: Clutch refabrication may lead to exposure to asbestos of sufficient magnitude to cause asbestosis and lung cancer.
相似文献
18.
Cornélio DA Schmid-Braz AT Cavalli LR Lima RS Ribeiro EM Cavalli IJ 《Cancer Genetics and Cytogenetics》1999,115(2):128-133
Gynecomastia is a benign condition that frequently occurs in the male breast gland; however, the cytogenetic data on this entity are very limited. To our knowledge, three cases have been reported in the literature, and the only one with an abnormal karyotype had a concomitant breast carcinoma. In this study we report clonal chromosomal alterations in a gynecomastia sample without any signs of adjacent malignant tissue. The nonrandom abnormalities observed were a deletion of 12p, monosomies of chromosomes 9, 17, 19, and 20, and the presence of a marker chromosome. Most of these alterations have been previously described in the literature in other breast lesions, including benign and malignant (male and female) tumors, indicating their recurrence and nonrandomness in abnormal processes of the mammary gland. 相似文献
19.
Large animal studies show that the effects of fixed doses of anticancer drugs vary predictably with multi-frequency rhythms' stages--components of a genetically--anchored, habitat synchronized, cosmically influenced time structure--the chronome. Both the tolerance by the host of the toxic drugs and the treatment's efficacy in killing cancer cells contribute to these changes. Chronotherapy, timing treatment according to the chronome, attempts to first maximize treatment efficacy while also minimizing toxicity, so as to optimize the therapeutic ratio. Outcomes have been improved by several hundred per cent by treating rodents at the "right" time with single or multiple agents under controlled laboratory conditions, and by chronoradiotherapy of human perioral tumors, using tumor temperature as a marker rhythm. 相似文献
20.
The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies 总被引:3,自引:0,他引:3
Geoffrey R. Howe Kristan J. Aronson Enrique Benito Roberto Castelleto Jacqueline Cornée Stephen Duffy Richard P. Gallagher José M. Iscovich Jiao Deng-ao Rudolf Kaaks Gabriel A. Kune Susan Kune Hin P. Lee Marion Lee Anthony B. Miller Ruth K. Peters John D. Potter Elio Riboli Martha L. Slattery Dimitrios Trichopoulos Albert Tuyns Anastasia Tzonou Lyndsey F. Watson Alice S. Whittemore Anna H. Wu-Williams Zheng Shu 《Cancer causes & control : CCC》1997,8(2):215-228
The objective of this study was to examine the effects of the intakeof dietary fat upon colorectal cancer risk in a combined analysis of datafrom 13 case-control studies previously conducted in populations withdiffering colorectal cancer rates and dietary practices. Original datarecords for 5,287 cases of colorectal cancer and 10,470 controls werecombined. Logistic regression analysis was used to estimate odds ratios (OR)for intakes of total energy, total fat and its components, and cholesterol.Positive associations with energy intake were observed for 11 of the 13studies. However, there was little, if any, evidence of anyenergy-independent effect of either total fat with ORs of 1.00, 0.95, 1.01,1.02, and 0.92 for quintiles of residuals of total fat intake (P trend =0.67) or for saturated fat with ORs of 1.00, 1.08, 1.06, 1.21, and 1.06 (Ptrend = 0.39). The analysis suggests that, among these case-control studies,there is no energy-independent association between dietary fat intake andrisk of colorectal cancer. It also suggests that simple substitution of fatby other sources of calories is unlikely to reduce meaningfully the risk ofcolorectal cancer. 相似文献