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51.
Association of Kaposi's Sarcoma-Associated Herpesvirus-Positive Primary Effusion Lymphoma With Expression of the CD138/Syndecan-1 Antigen 总被引:8,自引:4,他引:4
52.
Robert M. Murphey Francisco A. Moura Duarte Maria Cilia Torres Penedo 《Behavior genetics》1980,10(2):171-181
Bovine cattle from various parts of the world were studied in a physically and culturally homogeneous environment. The animals' approachability by a human in open pastures was associated with breed differences. Dairy breeds were more approachable than beef breeds, while a comparison between European (Bos taurus) and humpbacked (B. indicus) stock yielded equivocal results. Raising dairy breeds for meat and raising beef breeds as milch cows had little overall effect on their approachability. Genetic affiliation was a much more powerful variable than treatment. Under ordinary rearing conditions within a particular ethnoenvironmental medium, it would appear that approachability is a relatively stable property of cattle breeds.The research was supported by the Applied Science Unit, Department of Scientific Affairs, Organization of American States. 相似文献
53.
Differential expression of IEG mRNA in rat brain following acute treatment with clozapine or haloperidol: a semi-quantitative RT-PCR study 总被引:1,自引:0,他引:1
Robbins MJ Critchlow HM Lloyd A Cilia J Clarke JD Bond B Jones DN Maycox PR 《Journal of psychopharmacology (Oxford, England)》2008,22(5):536-542
Antipsychotic drugs have been shown to modulate immediate early gene (IEG) expression in rat brain regions that are associated with schizophrenia, which may be directly linked to their immediate therapeutic benefit. In this study, we analysed the expression profile of a series of IEGs (c-fos, c-jun, fra-1, Krox-20, Krox-24, arc, sgk-1, BDNF and NARP) in six rat brain regions (prefrontal cortex, hippocampus, striatum, nucleus accumbens, thalamus and cerebellum). Rats (n=5) were administered either clozapine (20 mg/kg i.p.), haloperidol (1 mg/kg i.p.) or the appropriate vehicle with pre-treatment times of 1, 6 and 24 h. IEG expression was analysed in these regions by Taqman RT-PCR. The spatial and temporal profile of IEG induction following antipsychotic drug treatment correlates with regions associated with the efficacy and side effect profile of each drug. In particular, sgk-1 expression levels after antipsychotic drug treatment may have predictive value when investigating the profile of a novel antipsychotic drug. 相似文献
54.
Corradetti R Mlinar B Falsini C Pugliese AM Cilia A Destefani C Testa R 《The Journal of pharmacology and experimental therapeutics》2005,315(1):109-117
The pharmacological properties of cyclohexanecarboxylic acid, {2-[4-(2-bromo-5-methoxybenzyl)piperazin-1-yl]ethyl}-(2-trifluoromethoxyphenyl)amide (Rec 27/0224), and cyclohexanecarboxylic acid, (2-methoxy-phenyl)-{2-[4-(2-methoxyphenyl)-piperazin-1-yl]ethyl}amide (Rec 27/0074), were characterized using radioligand displacement and guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS) binding assays, as well as electrophysiological experiments, in rat hippocampal and dorsal raphe nucleus (DRN) slices. Both compounds showed a high affinity (Ki, approximately 1 nM) and selectivity (>70-fold) at human 5-hydroxytryptamine (5-HT)1A receptors versus other 5-HT receptors. In [35S]GTPgammaS binding assays on HeLa cells stably expressing human 5-HT1A receptors, Rec 27/0224 and Rec 27/0074 inhibited basal [35S]GTPgammaS binding by 44.8 +/- 1.7% (pEC50 = 8.58) and 25 +/- 2.5% (pEC50 = 8.86), respectively. In intracellularly recorded CA1 pyramidal cells, 5-HT1A (hetero)receptor-mediated hyperpolarization, elicited by 100 nM 5-carboxamidoytryptamine (5-CT), was partially antagonized by Rec 27/0224 (approximately 50%; IC50 = 18.0 nM) and Rec 27/0074 (74%; IC50 = 0.8 nM). In extracellularly recorded DRN serotonergic neurons, Rec 27/0224 and Rec 27/0074 fully antagonized the inhibition of firing caused by the activation of 5-HT1A (auto)receptors by 30 nM 5-CT with an IC50 of 34.9 nM and 16.5 nM, respectively. The antagonism had a slow time course, reaching a steady state within 60 min. Both compounds also antagonized the citalopram-elicited, endogenous 5-HT-mediated inhibition of cell firing. In conclusion, Rec 27/0224 and Rec 27/0074 exhibited inverse agonism in [35S]GTPgammaS binding assays and differential antagonistic properties on 5-HT1A receptor-mediated responses in the hippocampus but not in the DRN. Whether this differential effect is causally related to inverse agonist activity is unclear. The qualitatively different nature of the antagonism in the hippocampus versus the DRN clearly distinguishes the compounds from neutral antagonists, such as N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N-2-pyridinylcyclo-hexanecarboxamide (WAY-100635). 相似文献
55.
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57.
The development of an impulse control disorder (ICD) is now recognized as a potential nonmotor adverse effect of dopamine
replacement therapy in Parkinson’s disease (PD). Here, recent epidemiological, neurophysiological and genetic advances are
summarized to outline potential mechanisms involved. It is safe to say that dopaminergic drugs, particularly dopamine agonists,
are able to induce ICDs only in a minority of patients, while the majority are somehow protected from this adverse effect.
While it seems clear that men with early-onset PD are more vulnerable, other predisposing factors, such as various current
or pre-PD personality traits, are a matter of debate. In terms of neurophysiological advances, one may find striking analogies
to the addiction literature suggesting a causal chain beginning with certain predisposing conditions of striatal dopamine
synapses, an “unnatural” increase of dopamine stimulation and a characteristic pattern of resulting functional changes in
remote networks of appetitive drive and impulse control. Future prospects include potential add-on medications and the possible
identification of genetic predispositions at a genome-wide scale. Functional imaging of pharmacogenetic interactions (imaging
pharmacogenomics) may be an important tool on that road. 相似文献
58.
Committee for Orphan Medicinal Products the European Medicines Westermark K Holm BB Söderholm M Llinares-Garcia J Rivière F Aarum S Butlen-Ducuing F Tsigkos S Wilk-Kachlicka A N'Diamoi C Borvendég J Lyons D Sepodes B Bloechl-Daum B Lhoir A Todorova M Kkolos I Kubáčková K Bosch-Traberg H Tillmann V Saano V Héron E Elbers R Siouti M Eggenhofer J Salmon P Clementi M Krieviņš D Matulevičiene A Metz H Vincenti AC Voordouw A Dembowska-Bagińska B Nunes AC Saleh FM Foltánová T Možina M 《Nature reviews. Drug discovery》2011,10(5):341-349
In 2000, regulation on orphan medicinal products was adopted in the European Union with the aim of benefiting patients who suffer from serious, rare conditions for which there is currently no satisfactory treatment. Since then, more than 850 orphan drug designations have been granted by the European Commission based on a positive opinion from the Committee for Orphan Medicinal Products (COMP), and more than 60 orphan drugs have received marketing authorization in Europe. Here, stimulated by the tenth anniversary of the COMP, we reflect on the outcomes and experience gained in the past decade, and contemplate issues for the future, such as catalysing drug development for the large number of rare diseases that still lack effective treatments. 相似文献
59.
Michela Barichella Marco Severgnini Roberto Cilia Erica Cassani Carlotta Bolliri Serena Caronni Valentina Ferri Raffaella Cancello Camilla Ceccarani Samanta Faierman Giovanna Pinelli Gianluca De Bellis Luigi Zecca Emanuele Cereda Clarissa Consolandi Gianni Pezzoli 《Movement disorders》2019,34(3):396-405
60.
Goldwurm S Zini M Di Fonzo A De Gaspari D Siri C Simons EJ van Doeselaar M Tesei S Antonini A Canesi M Zecchinelli A Mariani C Meucci N Sacilotto G Cilia R Isaias IU Bonetti A Sironi F Ricca S Oostra BA Bonifati V Pezzoli G 《Parkinsonism & related disorders》2006,12(7):410-419
We analysed the Leucine-Rich Repeat Kinase 2 (LRRK2) gene for the G2019S mutation in 1245 consecutive, unrelated patients with primary degenerative parkinsonism, and collected information on medical history, motor, cognitive and neuropsychiatric functions to characterize the clinical phenotype associated to the G2019S mutation. The mutation was detected in heterozygous state in 19 probands (1.7%), and in five additional affected relatives. Clinical features in carriers were those of typical, idiopathic Parkinson's disease. However, behavioural abnormalities were frequent (87%), suggesting a more widespread limbic involvement in G2019S carriers. 相似文献