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81.
Frederic Pontvianne Todd Blevins Chinmayi Chandrasekhara Iva Mozgová Christiane Hassel Olga M.F. Pontes Sarah Tucker Petr Mokro? Veronika Muchová Ji?í Fajkus Craig S. Pikaard 《Genes & development》2013,27(14):1545-1550
Eukaryotes can have thousands of 45S ribosomal RNA (rRNA) genes, many of which are silenced during development. Using fluorescence-activated sorting techniques, we show that active rRNA genes in Arabidopsis thaliana are present within sorted nucleoli, whereas silenced rRNA genes are excluded. DNA methyltransferase (met1), histone deacetylase (hda6), or chromatin assembly (caf1) mutants that disrupt silencing abrogate this nucleoplasmic–nucleolar partitioning. Bisulfite sequencing data indicate that active nucleolar rRNA genes are nearly completely demethylated at promoter CGs, whereas silenced genes are nearly fully methylated. Collectively, the data reveal that rRNA genes occupy distinct but changeable nuclear territories according to their epigenetic state. 相似文献
82.
Ulrike Klein Kai Neben Thomas Hielscher Christiane Heiß Anthony D. Ho Hartmut Goldschmidt 《Annals of hematology》2011,90(4):429-439
Over the past decade, treatment options for patients with multiple myeloma (MM) have improved substantially, resulting in
better response rates and prolonged overall survival (OS). Nevertheless, MM remains a challenging disease, especially if renal
insufficiency (RI) or extensive pre-treatment aggravates the assignment of the optimal treatment schedule. In this retrospective
study, we analyzed the outcome of lenalidomide plus dexamethasone in 167 patients with relapsed or refractory MM with focus
on RI. The baseline creatinine clearance (CLCr) was normal in 94 patients (CLCr ≥ 80 ml/min), while RI was observed in 73 patients, including 40 patients with mild RI (50 ≤ CLCr < 80 ml/min) and 33 patients with moderate or severe RI (CLCr < 50 ml/min). Response rates declined depending on the severity of RI, being 67% among patients with normal kidney function,
60% among patients with mild RI and 49% among patients with moderate or severe RI. Time to progression (TTP) was significantly
reduced in patients with severe RI and in case of >2 previous treatment lines. OS was not significantly different between
patients with normal and impaired renal function. In contrast, the number of previous treatment lines (2 vs. <2) and the use
of novel agents like bortezomib or thalidomide prior to lenalidomide plus dexamethasone therapy had a more adverse effect
on OS. In conclusion, lenalidomide plus dexamethasone is an effective regimen for relapsed or refractory patients with MM
complicated by RI with manageable toxicity. 相似文献
83.
Information‐seeking and use of information resources among melanoma patients of German skin cancer centers
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Philippe Bouvet Raymond Ruimy Christiane Bouchier Nathalie Faucher Christelle Mazuet Michel R. Popoff 《Journal of clinical microbiology》2014,52(1):339-343
A nontoxigenic strain isolated from a fatal human case of bacterial sepsis was identified as a Clostridium strain from Clostridium botulinum group III, based on the phenotypic characters and 16S rRNA gene sequence, and was found to be related to the mosaic C. botulinum D/C strain according to a multilocus sequence analysis of 5 housekeeping genes. 相似文献
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87.
Christophe Chantrain Christiane Vermylen Lucienne Michaux Bénédicte Brichard Guy Cornu 《Pediatric hematology and oncology》2013,30(6):505-509
The authors report the case of a 5-year-old boy referred for thrombocytopenia and neutropenia. Bone marrow examination showed a myelodysplasia with clonal monosomy7. The acceleration of the disease was marked by the appearance of an additional cytogenetic abnormality, i.e., the deletion of the long arm of chromosome 5 in the clonal cells. RAS genemutationwas not detected. Chemotherapy was started to achieve complete remission before a bone marrow transplatation. This treatment was complicated by a prolonged a plasia and the patient died of systemic mycotic infection. 相似文献
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