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活体生物萤光成像技术(in vivo biolumines- cence imaging)是近年来发展起来的一项崭新的分子、基因表达的分析检测系统.与传统的检测方法相比具有巨大的优越性,堪称是分子基因检测领域的革命性技术.随着萤光成像设备的进一步完善以及转基因动物的构建开发,在欧美等发达国家活体生物萤光成像技术已被广泛地应用于感染、肿瘤免疫及治疗、自身免疫性疾病、器官移植、基因治疗、药物开发等实验领域.本文就活体生物萤光成像技术的发展和应用作如下综述. 相似文献
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Michael N Passarelli Polly A Newcomb Andrea Z LaCroix Dorothy S Lane Gloria YF Ho Rowan T Chlebowski 《Journal of bone and mineral research》2013,28(9):2043-2048
Bisphosphonates are widely prescribed to increase bone density in postmenopausal women with osteopenia or osteoporosis. Aminobisphosphonates have numerous anticancer properties and reduce bone metastases in cancer patients. Several studies, including the Women's Health Initiative (WHI), have found that use of oral bisphosphonates is associated with reduced risk of developing breast cancer, but less is known about associations with other common malignancies in women such as colorectal cancer (CRC). A few case‐control and retrospective cohort studies have reported decreased risk of CRC among bisphosphonate users. In contrast, a prospective cohort study found no association. We evaluated the association between oral bisphosphonate use and CRC incidence in 156,826 postmenopausal women, ages 50 to 79 years, who participated in WHI clinical trials and observational study. A detailed health interview was conducted at baseline, and bisphosphonate use was ascertained from an inventory of regularly used medications at baseline and over follow‐up. A total of 1931 women were diagnosed with incident invasive CRC during a median follow‐up of 12 years. Alendronate was the most commonly used bisphosphonate, accounting for >90% of the total person‐years of use. The association between oral bisphosphonate use and CRC risk did not reach statistical significance (hazard ratio [HR] from multivariable‐adjusted models = 0.88; 95% confidence interval [CI] 0.72–1.07; p = 0.19). Furthermore, we did not observe greater risk reductions for women with longer duration of use. Uncontrolled confounding may explain why previous studies have observed an association. 相似文献
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Background: Hypercementosis may be idiopathic or secondary to either local factors or systemic disorders. However, periodontitis as an aetiologic factor in the formation of hypercementosis has never been documented in the literature. Methods: We report a case of periodontitis with hypercementosis, affecting the right mandibular second premolar and first molar teeth. Results: Our patient’s maxillary was edentulous and the mandibular teeth #47, #43, #42, #41, #31, #32, #33, #36, #37 were missing. The right mandibular second premolar and first molar had first‐degree mobility and second‐degree mobility respectively. Periodontal pocket depth in the right mandibular second premolar and first molar were 5 mm and 8 mm at buccal pockets, 6 mm and 9 mm at distal pockets, respectively. The radiograph revealed that the roots of both teeth were grossly thickened and blunted. The right mandibular first molar was extracted and sent for histopathological examination. The definitive diagnoses were periodontitis and hypercementosis. Conclusions: The concomitant occurrence of periodontitis and hypercementosis in our patient suggests that periodontitis is a predisposing factor for hypercementosis development. This condition may be associated with various local stimuli and possible compensative phenomenon. 相似文献
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1临床资料2003-03/2004-12就诊性病患者100(男68,女32)例;年龄19~60岁;文化程度中学以下78例,大专以上22例;职业个体49例,有工作单位39例,无业12例;病种尖锐湿疣52例、非淋菌性尿道炎20例、淋病18例、梅毒3例、生殖器疱疹7例; 96例经0.5~6.0 mo的治疗康复,4例病情好转. 接诊过程从交谈及肢体语言发现,98%的患者就诊时对病史遮遮掩掩,甚至隐瞒,觉得羞耻,见不得人,愧对家人;68%的患者由于对性病的一知半解,存在有恐惧感、悲观、自责、压抑、焦虑的情绪表现;36%的患者担心家人、同事知道病情而引发一系列家庭、工作问题[1];43%的患者担心病情加重、扩散、传染家人、治疗后复发、未彻底治愈以及治疗费用太高等. 相似文献
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