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71.
Shigeo Hayashi Katsuyo Ohashi Eriko Nakata Chie Emoto 《Medicinal chemistry research》2014,23(1):526-552
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Propensity score‐matched study of laparoscopic and open surgery for colorectal cancer in rural hospitals
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Toshihiro Nakao Mitsuo Shimada Kozo Yoshikawa Jun Higashijima Takuya Tokunaga Masaaki Nishi Chie Takasu Hideya Kashihara Ichio Suzuka Takashi Nishizaki Hiroshi Okitsu Toshiyuki Yagi Hidenori Miyake Murato Miura Mitsutoshi Fukuyama Daisuke Wada Yoshiaki Bando 《Journal of gastroenterology and hepatology》2016,31(10):1700-1704
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Onishi C Ikejiri F Kawakami K Miyake T Kumanomido S Inoue M Takahashi T Tanaka J Yamamoto M Sugimoto T Suzumiya J 《Annals of hematology》2011,90(11):1293-1297
The Asian variant of intravascular large B cell lymphoma is a special type of intravascular lymphoma with hemophagocytic syndrome and hypercytokinemia including interleukin-6, which stimulates antidiuretic hormone synthesis in the hypothalamus. We present here that the syndrome of inappropriate antidiuretic hormone secretion frequently occurs in patients with the Asian variant of intravascular large B cell lymphoma. The syndrome of inappropriate antidiuretic hormone secretion was found in eight of 118 (6.8%) lymphoma patients at the first diagnosis. Although there were six (5.1%) among 118 lymphoma patients with the Asian variant of intravascular large B cell lymphoma, four of the six patients (66.7%) developed the syndrome of inappropriate antidiuretic hormone secretion. In four patients with the Asian variant of intravascular large B cell lymphoma with the syndrome of inappropriate antidiuretic hormone secretion, elevated serum interleukin-6 and low sodium levels were almost normalized after chemotherapy. The Asian variant of intravascular large B cell lymphoma patients frequently develop the syndrome of inappropriate antidiuretic hormone secretion, and interleukin-6 might play a role in the occurrence of this disease. We should pay attention to hyponatremia caused by the syndrome of inappropriate antidiuretic hormone secretion in patients with the Asian variant of intravascular large B cell lymphoma. 相似文献
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Takashi Tsukahara Masaru Tamura Hiromichi Yamazaki Hideyuki Kurihara Shigeru Matsuzaki 《Journal of cancer research and clinical oncology》1992,118(3):171-175
Summary The effects of -difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greater effect on the survival rate than the single therapies, the effect being additive. The concentration of putrescine, spermidine, andN
1-acetylspermidine in tumor tissues was lowered by DFMO, while that of spermine was slightly elevated. Radiation decreased the concentration of all the polyamines, putrescine, spermidine, spermine andN
1-acetylspermidine. The concomitant treatment with DFMO and radiation further decreased the concentrations of putrescine andN
1-acetylspermidine in tumor tissues. The survival period of glioma-bearing rats is inversely correlated with the tissue levels of putrescine plusN
1-acetylspermidine.Abbreviations DFMO
-difluoromethylornithine
- BrdUrd
bromodeoxyuridine 相似文献
79.
Yoichi Otaki Takashi Ashikaga Taro Sasaoka Ken Kurihara Shunji Yoshikawa Mitsuaki Isobe 《Cardiovascular Revascularization Medicine》2019,20(2):120-125
Background
Long-term clinical outcomes of permanent polymer everolimus-eluting stent (PP-EES) implantation after rotational atherectomy (RA) have not been fully evaluated. We sought to investigate the long-term clinical outcomes of PP-EES implantation after RA and assess the impact of hemodialysis on this treatment strategy.Methods
Patients who underwent percutaneous coronary intervention (PCI) with PP-EES at 22 institutions between January 2010 and December 2011 were enrolled in this multicenter, observational trial. From a total of 1918 registered patients, 113 patients with 115 de-novo lesions who underwent PCI with PP-EES following RA were retrospectively analyzed. The primary endpoint was a major adverse cardiac event (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinically driven target lesion revascularization (TLR).Results
Long-term follow-up was available for 112 patients (99.1%). The median follow-up period was 2.9 (interquartile range 1.9–3.6) years. The mean age of the patients was 72.3?±?8.8?years and 64 patients (56.6%) had chronic kidney disease (≥stage 3, 42 on hemodialysis). The cumulative incidences of MACE, non-fatal MI, and TLR were 22.1%, 5.3%, and 10.6%, respectively. Cox's proportional hazards analysis showed that the independent predictors of TLR were hemodialysis and chronic total occlusion. (HR, 14.1; 95% CI, 1.74–155.5; p?=?0.01, HR, 9.01; 95% CI, 1.34–62.5; p?=?0.02).Conclusions
PP-EES implantation after lesion modification by RA is considered to be a feasible treatment strategy for heavily calcified lesions. Hemodialysis and chronic total occlusion appeared to be associated with TLR. 相似文献80.
Atsushi Yoshimura Mitsuru Kimura Sachio Matsushita Jun-ichi Yoneda Hitoshi Maesato Yasunobu Komoto Hideki Nakayama Hiroshi Sakuma Yosuke Yumoto Tsuyoshi Takimura Tomomi Tohyama Chie Iwahara Takeshi Mizukami Akira Yokoyama Susumu Higuchi 《Alcoholism, clinical and experimental research》2021,45(11):2335-2346